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14,881 results
  • "Passenger gene" problem in transgenic C57BL/6 mice used in hearing research. [Journal Article]
    Neurosci Res 2019Suzuki J, Inada H, … Osumi N
  • Despite recent advances in genome engineering technologies, traditional transgenic mice generated on a mixed genetic background of C57BL/6 and 129/Sv mice remain widely used in age-related hearing loss (AHL) research, since C57BL/6 mice exhibit early onset and progression of AHL due to a mutation in cadherin 23-encoding gene (Cdh23753G>A). In these transgenic mice, backcrossing for more than 10 g…
  • The long-term social value of granulocyte colony-stimulating factors. [Journal Article]
    Am J Manag Care 2019; 25(10):486-493Sexton Ward A, Kabiri M, … Goldman D
  • CONCLUSIONS: Current use of G-CSF prophylaxis would provide $96 billion in SV over the next 10 years. Targeting G-CSF prophylaxis to align with guidelines would more than double SV, highlighting the substantial value of appropriate FN risk assessment and targeted G-CSF prophylaxis.
  • The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms. [Journal Article]
    J Neurosci 2019; 39(42):8209-8216Chanaday NL, Cousin MA, … Morgan JR
  • Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs) locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs are recovered by either fusion pore closure (kiss-and-run) or clathrin-mediated endocytosis directly from the plasma membrane. However, recent data have revealed that SV formation is more complex than previously envisag…
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