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Unbound Medicine.
(Swine Influenza A H1N1 virus)
17,326 results
  • JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential. [Journal Article]
    J Med Microbiol. 2023 Jan; 72(1)Mollett BC, Everett HE, … Banyard AC
  • Swine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viru…
  • Physical interventions to interrupt or reduce the spread of respiratory viruses. [Review]
    Cochrane Database Syst Rev. 2023 Jan 30; 1(1):CD006207.Jefferson T, Dooley L, … Conly JM
  • CONCLUSIONS: The high risk of bias in the trials, variation in outcome measurement, and relatively low adherence with the interventions during the studies hampers drawing firm conclusions. There were additional RCTs during the pandemic related to physical interventions but a relative paucity given the importance of the question of masking and its relative effectiveness and the concomitant measures of mask adherence which would be highly relevant to the measurement of effectiveness, especially in the elderly and in young children. There is uncertainty about the effects of face masks. The low to moderate certainty of evidence means our confidence in the effect estimate is limited, and that the true effect may be different from the observed estimate of the effect. The pooled results of RCTs did not show a clear reduction in respiratory viral infection with the use of medical/surgical masks. There were no clear differences between the use of medical/surgical masks compared with N95/P2 respirators in healthcare workers when used in routine care to reduce respiratory viral infection. Hand hygiene is likely to modestly reduce the burden of respiratory illness, and although this effect was also present when ILI and laboratory-confirmed influenza were analysed separately, it was not found to be a significant difference for the latter two outcomes. Harms associated with physical interventions were under-investigated. There is a need for large, well-designed RCTs addressing the effectiveness of many of these interventions in multiple settings and populations, as well as the impact of adherence on effectiveness, especially in those most at risk of ARIs.
  • The arithmetic topology of genetic alignments. [Journal Article]
    J Math Biol. 2023 Jan 25; 86(3):34.Barrett C, Bura A, … Reidys C
  • We propose a novel mathematical paradigm for the study of genetic variation in sequence alignments. This framework originates from extending the notion of pairwise relations, upon which current analysis is based on, to k-ary dissimilarity. This dissimilarity naturally leads to a generalization of simplicial complexes by endowing simplices with weights, compatible with the boundary operator. We in…
  • Which Virus Will Cause the Next Pandemic? [Journal Article]
    Viruses. 2023 Jan 10; 15(1)Neumann G, Kawaoka Y
  • One of the most pressing and consequential problems in infectious disease research is to better understand the potential of viruses to cause a pandemic, or, in simple terms, determine which virus will cause the next pandemic. We here define pandemics as WHO-declared pandemics, or disease outbreaks commonly referred to as pandemics that predate the WHO pandemic framework. Despite extensive researc…
  • Oseltamivir-resistant h1n1 influenza virus: Case report. [Case Reports]
    J Pak Med Assoc. 2022 Oct; 72(10):2112-2113.Kayani MD
  • Swine flu is mainly caused by influenza virus strain H1N1. This strain of influenza has been found to cause seasonal flu. Animals are common source of influenza virus, in particular, pigs. Transmissions from animals to humans are reported on several occasions worldwide. These cases are usually mild to moderate in nature and are usually not fatal. Here we describe the case of a healthy woman from …
  • An integrated dual-layer microfluidic platform for multiple respiratory viruses screening. [Journal Article]
    Anal Chim Acta. 2023 Feb 15; 1242:340812.Wang H, Xu J, … Li M
  • Currently, the coronavirus disease 2019 (COVID-19) caused by the outbreak of a novel coronavirus (SARS-CoV-2) is spreading rapidly worldwide. Due to the high incidence of influenza coinciding with SARS-CoV-2, rapid detection is crucial to prevent spreading. Here, we present an integrated dual-layer microfluidic platform for specific and highly sensitive SARS-CoV-2, influenza viruses A (FluA) H1N1…
  • Enhancing the protection of influenza virus vaccines with BECC TLR4 adjuvant in aged mice. [Journal Article]
    Sci Rep. 2023 Jan 13; 13(1):715.Haupt R, Baracco L, … Frieman MB
  • Influenza A virus (IAV) is a leading cause of respiratory disease worldwide often resulting in severe morbidity and mortality. We have previously shown that the Bacterial Enzymatic Combinatorial Chemistry (BECC) adjuvants, BECC438 and BECC470, formulated with an influenza virus hemagglutinin (HA) protein vaccine, offer greater protection from influenza virus challenge in mouse respiratory models …
  • Submerged leaves of live indoor foliage plants adsorb H1N1 influenza virus from suspension. [Journal Article]
    Plant Signal Behav. 2023 12 31; 18(1):2163869.Song HJ, Yang SW, … Kim HJ
  • Control of hazardous indoor particles using plants has attracted interest due to the increasing worldwide air pollution and spread of pandemic-causing viruses. However, the interaction between human pathogenic viruses (HPVs) and live plants has not been examined largely due to issues in detecting tiny amounts of infectious viruses in a carrier (such as an aerosol) and the lack of suitable examina…
  • Influenza-Associated Excess Mortality by Age, Sex, and Subtype/Lineage: Population-Based Time-Series Study With a Distributed-Lag Nonlinear Model. [Journal Article]
    JMIR Public Health Surveill. 2023 Jan 11; 9:e42530.Li L, Yan ZL, … Ou CQ
  • CONCLUSIONS: Influenza was associated with substantial mortality in Guangzhou, occurring predominantly in the elderly, even after considering mortality displacement. The mortality burden of influenza B, particularly B/Yamagata, cannot be ignored. Contrasting sex differences were found in influenza-associated excess mortality from respiratory diseases and from cardiovascular diseases; the underlying mechanisms need to be investigated in future studies. Our findings can help us better understand the magnitude and time-course of the effect of influenza on mortality and inform targeted interventions for mitigating the influenza mortality burden, such as immunizations with quadrivalent vaccines (especially for older people), behavioral campaigns, and treatment strategies.
  • Revisiting live attenuated influenza vaccine efficacy among children in developing countries. [Review]
    Vaccine. 2023 01 27; 41(5):1009-1017.Bagga S, Krishnan A, Dar L
  • Seasonal influenza epidemics cause significant pediatric mortality and morbidity worldwide. Live attenuated influenza vaccines (LAIVs) can be administered intranasally, induce a broad and robust immune response, demonstrate higher yields during manufacturing as compared to inactivated influenza vaccines (IIVs), and thereby represent an attractive possibility for young children in developing count…
  • Peniandranoids A-E: Meroterpenoids with Antiviral and Immunosuppressive Activity from a Penicillium sp. [Journal Article]
    J Nat Prod. 2023 01 27; 86(1):66-75.Chang JL, Gan YT, … Ruan HL
  • Peniandranoids A-E (1-5), five new meroterpenoids, together with three known analogues (6-8), were isolated from the fermentation of a soil-derived fungus, Penicillium sp.sb62. Their structures including absolute configurations were determined by extensive spectroscopic analysis, and the absolute configurations of compounds 1 and 5 were further elucidated by single-crystal X-ray diffraction. Peni…
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