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2,685 results
  • ADPedKD: A Global Online Platform on the Management of Children With ADPKD. [Journal Article]
    Kidney Int Rep 2019; 4(9):1271-1284De Rechter S, Bockenhauer D, … ADPedKD Consortium
  • Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of renal failure. For several decades, ADPKD was regarded as an adult-onset disease. In the past decade, it has become more widely appreciated that the disease course begins in childhood. However, evidence-based guidelines on how to manage and approach children diagnosed with or at risk of ADPKD are lacking. A…
  • KCa3.1 Channels Confer Radioresistance to Breast Cancer Cells. [Journal Article]
    Cancers (Basel) 2019; 11(9)Mohr CJ, Gross D, … Lukowski R
  • KCa3.1 K+ channels reportedly contribute to the proliferation of breast tumor cells and may serve pro-tumor functions in the microenvironment. The putative interaction of KCa3.1 with major anti-cancer treatment strategies, which are based on cytotoxic drugs or radiotherapy, remains largely unexplored. We employed KCa3.1-proficient and -deficient breast cancer cells derived from breast cancer-pron…
  • Anti-inflammatory secondary metabolites from the stems of Millettia dielsiana Harms ex Diels. [Journal Article]
    Carbohydr Res 2019; 484:107778Dat LD, Tu NTM, … Thao NP
  • A phytochemical investigation for the constituents of the stems of Millettia dielsiana Harms ex Diels resulted in the isolation of a new isoflavone glycoside, mildiside A (1), and 14 known compounds (2-15). Their chemical structures were determined using a combination of IR, NMR, MS, and optical rotation analysis, as well as comparison with the literature data. The ethanolic (EtOH) extract and se…
  • The ER protein TLC domain 3B2 and its enzymatic product lactosylceramide enhance chondrocyte maturation. [Journal Article]
    Connect Tissue Res 2019; :1-7Antonyan L, Martineau C, St-Arnaud R
  • CONCLUSIONS: TLCD3B2 localized to the endoplasmic reticulum, with both the N- and C-termini facing the cytosolic compartment. Chondrogenic ATDC5 cells stably overexpressing Tlcd3b2 showed elevated type 2 (Col2a1) and type 10 (Col10a1) collagen gene expression and increased proteoglycan synthesis, and the effect on Col2a1 was enhanced by treatment with 24,25(OH)2D3. LacCer treatment of ATDC5 cells potentiated Col10a1 expression. Our results show that TLCD3B2 is an ER protein and implicate its expression and enzymatic product in chondrocyte maturation.
  • "Tram-line" Calcifications in Granulomatosis with Polyangiitis. [Case Reports]
    J Clin Imaging Sci 2019; 9:13Livingston D, Rajan C, … Bhatt S
  • Nephrocalcinosis consists of deposition of calcium in the renal parenchyma. Renal cortical calcification is a rare entity in comparison to calcium deposits in the medulla and is seen only in a handful of pathologies with corresponding characteristic patterns on imaging. Thin linear calcifications may get deposited in the peripheral renal cortex suggestive of cortical necrosis due to a vascular in…
  • Macroscopic road safety impacts of public transport: A case study of Melbourne, Australia. [Journal Article]
    Accid Anal Prev 2019; 132:105270Truong LT, Currie G
  • Mode shift from private vehicle to public transport is often considered as a potential means of improving road safety, given public transport's lower fatality rates. However, little research has examined how public transport travel contributes to road safety at a macroscopic level. Further, there is a limited understanding of the individual effects of different public transport modes. This paper …
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