- Fine needle aspiration cytology of a recurrent parotid tumour. [Journal Article]
- CCytopathology 2018 Aug 20
- A 62 year female presented with a progressively increasing hard, fixed, non tender swelling over the left check over an old surgical scar. The lesion measured 3 cm x 2 cm in size. Fine needle aspirat...
A 62 year female presented with a progressively increasing hard, fixed, non tender swelling over the left check over an old surgical scar. The lesion measured 3 cm x 2 cm in size. Fine needle aspiration cytology (FNAC) smears of the swelling showed loose aggregates, small sheets, and singly scattered cells with metachromatic chondromyxoid stroma in the background. The clusters of these cells appear three-dimensional with considerable crowding and overlapping (figure 1a and b). This article is protected by copyright. All rights reserved.
- [Retinal Vein Occlusions]. [Journal Article]
- KMKlin Monbl Augenheilkd 2018 Aug 20
- Retinal vein occlusions (RVO) are common retinal diseases. They are caused by an obstruction of retinal veins. RVO often result in visual deterioration and, in rare cases, can lead to blindness, but ...
Retinal vein occlusions (RVO) are common retinal diseases. They are caused by an obstruction of retinal veins. RVO often result in visual deterioration and, in rare cases, can lead to blindness, but also be asymptomatic. The prognosis is various and depends on the extent, the localization of the occlusion and the retinal perfusion, especially in the macular area. The etiology often is a thrombosis caused by vascular sclerosis, rarely a vasculitis. Because often an underlying disease is present the medical clarification is necessary. The ophthalmological treatment of the macular edema includes intravitreal injection of VEGF inhibitors and steroids. Laser photocoagulation is being proposed as second line treatment. Neovascular complications like preretinal neovascularizations with and without vitreous hemorrhage are treated with laser or vitrectomy. Iris neovascularization can also occur and is treated with laser photocoagulation or cyclophotocoagulation.
- Brain metastases from adenocarcinoma of the lung with truly cystic magnetic resonance imaging appearance. [Journal Article]
- CIClin Imaging 2018 Aug 08; 52:203-207
- Metastatic disease represents over half of all malignancies in brain parenchyma, and carcinoma when metastatic will often spread to the brain, with lung and breast tumors being the most common culpri...
Metastatic disease represents over half of all malignancies in brain parenchyma, and carcinoma when metastatic will often spread to the brain, with lung and breast tumors being the most common culprits. The suggestive features of metastatic disease on magnetic resonance imaging include peritumoral, vasogenic edema and avid postcontrast enhancement. We present the case of a 50-year-old male with an established diagnosis of metastatic adenocarcinoma of the lung treated with erlotinib who developed multiple cystic brain lesions on surveillance MRI. These cysts demonstrated T2 prolongation, suppressed completely on FLAIR, lacked surrounding edema, and featured a complete lack of enhancement. Due to the ambiguous imaging findings, brain biopsy was performed to establish the diagnosis. The pathology revealed a single layer of malignant cells lining brain parenchyma and focal areas of glandular growth. The intracranial lesions responded well to total brain radiation. This case is unique for the imaging findings most characteristic of simple cysts in biopsy-proven metastatic disease and may relate to the effects of erlotinib on metastatic brain tumors.
- Adenoid cystic carcinoma with myoepithelial predominance affecting maxilla and maxillary sinus. [Journal Article]
- JSJ Stomatol Oral Maxillofac Surg 2018 Aug 17
- Adenoid cystic carcinoma (ACC) represents less than 10% of all salivary gland tumors, rarely occurring centrally in the jaws. Herein we describe the case of a 36-year-old female patient presenting a ...
Adenoid cystic carcinoma (ACC) represents less than 10% of all salivary gland tumors, rarely occurring centrally in the jaws. Herein we describe the case of a 36-year-old female patient presenting a painless swelling in the right maxilla, resulting in marked facial asymmetry. Intraorally it was observed a swelling covered by an erythematous and irregular-surfaced mucosa, affecting the gingiva and crossing the midline of the hard palate. Imaging studies showed a mixed radiolucent-radiopaque lesion with ill-defined borders, involving the right side of the maxilla and the maxillary sinus. Incisional biopsy revealed basophilic cribriform tumoral islands and solid sheets of neoplastic cells invading bone trabeculae. Most of the tumoral cells presented myoepithelial characteristics, while few true luminal/epithelial cells were observed. To illustrate the epithelial-myoepithelial pattern, immunohistochemical reactions were performed, as well as double immunohistochemical staining. The diagnosis was intraosseous ACC, which features were discussed as well as the potential differential diagnosis.
- Efficacy of anti-TNF alpha in severe and refractory major vessel involvement of Behcet's disease: A multicenter observational study of 18 patients. [Journal Article]
- CIClin Immunol 2018 Aug 17
- CONCLUSIONS: TNFα-antagonists are safe and might be associated with a decreased risk of relapse at 9 months compared to conventional immunosuppressants in BD patients with major vessels disease.
- Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation with Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy. [Journal Article]
- PRPract Radiat Oncol 2018 Aug 17
- CONCLUSIONS: Brachytherapy APBI is associated with higher rates of grade 1 fibrosis and seroma than 3D-CRT but lower rates of grade 1 edema and grade 2-3 pain than 3D-CRT. Rates of radiation oncologist-reported "fair" or "poor" cosmetic outcome are higher with brachytherapy. We identified dosimetric parameters that predict reduced risk of adverse cosmetic outcome after brachytherapy-based APBI. Ipsilateral breast recurrence was equivalent for brachytherapy and 3D-CRT.
- Buccal adhesive films with moisturizer- the next level for dry mouth syndrome? [Journal Article]
- IJInt J Pharm 2018 Aug 17
- This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufac...
This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.
- Prevalence, Patterns, and Clinical Relevance of Hypoxic-Ischemic Injuries in Children Exposed to Abusive Head Trauma. [Journal Article]
- JNJ Neuroimaging 2018 Aug 19
- CONCLUSIONS: HII is the most common type of parenchymal damage in children victim of AHT, being present in 1/3 of patients with this condition, and correlates with more severe outcomes. Its presence is independent from other classic traumatic findings such as SDH and fractures.
- Case 257: Leiomyosarcoma of the Inferior Vena Cava. [Journal Article]
- RRadiology 2018; 288(3):901-908
- History A 65-year-old woman presented to her primary care physician with a history of progressive abdominal pain mainly in the upper quadrants, nausea, and edema in the bilateral symmetric lower extr...
History A 65-year-old woman presented to her primary care physician with a history of progressive abdominal pain mainly in the upper quadrants, nausea, and edema in the bilateral symmetric lower extremities. Other symptoms and use of medication or related drugs were denied. Physical examination findings were normal. The serum lactate dehydrogenase level was 302 U/L (5.04 μkat/L) (reference range, <247 U/L [4.12 μkat/L]), and all other laboratory data were within normal ranges. Electrocardiography and chest radiography revealed no abnormalities. The patient underwent contrast material-enhanced (100 mL of iomeprol [400 mg iodine per milliliter], Iomeron; Bracco Imaging) CT of the chest, abdomen, and pelvis; dynamic contrast-enhanced (13 mL of gadobenate dimeglumine, Multihance; Bracco Imaging) MRI of the chest and abdomen; and transthoracic echocardiography and cavography for further evaluation.
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- Gonadal and endocrine analysis of a gynandromorphic chicken. [Journal Article]
- EEndocrinology 2018 Aug 15
- Birds have a ZZ male; ZW female sex chromosome system. The relative roles of genetics and hormones in regulating avian sexual development has been revealed by studies on gynandromorphs. Gynandromorph...
Birds have a ZZ male; ZW female sex chromosome system. The relative roles of genetics and hormones in regulating avian sexual development has been revealed by studies on gynandromorphs. Gynandromorphs are rare bilateral sex chimeras, male on one side of the body and female on the other. We examined a naturally occurring gynandromorphic chicken that was externally male on the right side of the body and female on the left. The bird was diploid but with a mix of ZZ and ZW cells that correlated with the asymmetric sexual phenotype. The "male" side was 96% ZZ and the female side was 77% ZZ: 23% ZW. The gonads of this bird at sexual maturity were largely testicular. The right gonad was a testis, with SOX9+ Sertoli cells, DMRT1+ germ cells and active spermatogenesis. The left gonad was primarily testicular, but with some peripheral aromatase -expressing follicles. The bird had low levels of serum estradiol and high levels of testosterone, as expected for a male. Despite the low percentage of ZW cells on that side, the left side had female sex-linked feathering, smaller muscle mass, smaller leg and spur, and smaller wattle than the male side. This indicates that these sexually dimorphic structures must be at least partly independent of sex steroid effects. Even a small percentage of ZW cells appears sufficient to support female sexual differentiation. Given the lack of chromosome-wide dosage compensation in birds, various sexually dimorphic features may arise due to Z gene dosage differences between the sexes.