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(Thomas White hypothesis)
22 results
  • Spider silk colour covaries with thermal properties but not protein structure. [Journal Article]
    J R Soc Interface 2019; 16(156):20190199Blamires SJ, Cerexhe G, … Kasumovic MM
  • Understanding how and why animal secretions vary in property has important biomimetic implications as desirable properties might covary. Spider major ampullate (MA) silk, for instance, is a secretion earmarked for biomimetic applications, but many of its properties vary among and between species across environments. Here, we tested the hypothesis that MA silk colour, protein structure and thermal…
  • Urinary symptoms are associated with certain urinary microbes in urogynecologic surgical patients. [Journal Article]
    Int Urogynecol J 2018; 29(12):1765-1771Fok CS, Gao X, … Brubaker L
  • CONCLUSIONS: Two specific bacterial species detected in bladder urine, Atopobium vaginae and Finegoldia magna, are associated with preoperative urinary symptom severity in women undergoing POP/SUI surgery. The reservoir for Atopobium vaginae may be adjacent pelvic floor niches. This observation should be validated in a larger cohort to determine whether there is a microbiologic etiology for certain preoperative urinary symptoms.
  • Color polymorphic lures target different visual channels in prey. [Journal Article]
    Evolution 2016; 70(6):1398-408White TE, Kemp DJ
  • Selection for signal efficacy in variable environments may favor color polymorphism, but little is known about this possibility outside of sexual systems. Here we used the color polymorphic orb-web spider Gasteracantha fornicata, whose yellow- or white-banded dorsal signal attracts dipteran prey, to test the hypothesis that morphs may be tuned to optimize either chromatic or achromatic conspicuou…
  • Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. [Journal Article]
    Diabetes 2016; 65(6):1606-15Schafer MJ, White TA, … LeBrasseur NK
  • Considerable evidence implicates cellular senescence in the biology of aging and chronic disease. Diet and exercise are determinants of healthy aging; however, the extent to which they affect the behavior and accretion of senescent cells within distinct tissues is not clear. Here we tested the hypothesis that exercise prevents premature senescent cell accumulation and systemic metabolic dysfuncti…
  • Incontinence medication response relates to the female urinary microbiota. [Journal Article]
    Int Urogynecol J 2016; 27(5):723-33Thomas-White KJ, Hilt EE, … Wolfe AJ
  • CONCLUSIONS: Knowledge of an individual's urinary microbiome/microbiota may help refine UUI treatment. Complementary tools, DNA sequencing, and expanded urine culture provide information about bacteria that appear to be related to UUI incontinence status and treatment response in this population of adult women.
  • Dysfunctional Striatal Systems in Treatment-Resistant Schizophrenia. [Journal Article]
    Neuropsychopharmacology 2016; 41(5):1274-85White TP, Wigton R, … Shergill SS
  • The prevalence of treatment-resistant schizophrenia points to a discrete illness subtype, but to date its pathophysiologic characteristics are undetermined. Information transfer from ventral to dorsal striatum depends on both striato-cortico-striatal and striato-nigro-striatal subcircuits, yet although the functional integrity of the former appears to track improvement of positive symptoms of sch…
  • Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser. [Journal Article]
    Nat Methods 2014; 11(9):923-6Arnlund D, Johansson LC, … Neutze R
  • We describe a method to measure ultrafast protein structural changes using time-resolved wide-angle X-ray scattering at an X-ray free-electron laser. We demonstrated this approach using multiphoton excitation of the Blastochloris viridis photosynthetic reaction center, observing an ultrafast global conformational change that arises within picoseconds and precedes the propagation of heat through t…
  • Dysregulated but not decreased salience network activity in schizophrenia. [Journal Article]
    Front Hum Neurosci 2013; 7:65White TP, Gilleen J, Shergill SS
  • Effective estimation of the salience of environmental stimuli underlies adaptive behavior, while related aberrance is believed to undermine rational thought processes in schizophrenia. A network including bilateral frontoinsular cortex (FIC) and dorsal anterior cingulate cortex (dACC) has been observed to respond to salient stimuli using functional magnetic resonance imaging (fMRI). To test the h…
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