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(Tocilizumab AND ("Novel Coronavirus" OR COVID-19 OR SARS-CoV-2 OR 2019-nCoV))
1,201 results
  • Is Mucormycosis an inevitable complication of Covid-19 in India? [Editorial]
    Braz J Infect Dis. 2021 Jul 05 [Online ahead of print]Bhogireddy R, Krishnamurthy V, … Manohar S
  • Mucormycosis or black fungus infection is a less common disease but highly fatal infection, infecting the immunocompromised individuals. The site of predilection of the fungus is found to be lungs and brain in addition to its sequestration in sinusoidal spaces. Presently with the ongoing COVID 19 pandemic, the prevalence of this infection is found to be high in the Indian population. The fungus e…
  • Tocilizumab in COVID-19: Factors Associated With Mortality Before and After Treatment. [Journal Article]
    Front Pharmacol. 2021; 12:620187.Sarabia De Ardanaz L, Andreu-Ubero JM, … Requena P
  • Tocilizumab (TCZ) has been administered in SARS-CoV-2 pneumonia but the factors associated with mortality before and after treatment remain unclear. Cox regression models were used to estimate the predictors of time to death in a cohort of hospitalized patients with COVID-19 receiving TCZ. In addition, the mean differences between discharged and deceased patients in laboratory parameters measured…
  • Tocilizumab in patients with COVID-19: which patient, time, and dose? [Review]
    J Anesth. 2021 Jul 15 [Online ahead of print]Hasanin A, Mostafa M
  • Tocilizumab (TCZ) is a recombinant anti-interleukin-6 monoclonal antibody which showed uprising evidence as an anti-inflammatory agent which modulates the cytokine storm in patients with COVID-19. However, proper use of the drug requires selection of the appropriate patient and timing. The two main factors which might improve patient selection are the degree of respiratory failure and systemic in…
  • Coronavirus disease 2019 in children. [Journal Article]
    Curr Opin Infect Dis. 2021 Jul 13 [Online ahead of print]Levy ER, Blumenthal J, Chiotos K
  • CONCLUSIONS: Children generally fare well with acute COVID-19 infection, though critical illness is possible. Future research should focus on clarifying the role of children in SARS-CoV-2 transmission and optimal prevention strategies, particularly in the school setting, as well as evaluating pediatric vaccine candidates.
  • [Update 2021: COVID-19 from the Perspective of Haematology and Haemostaseology]. [Review]
    Dtsch Med Wochenschr. 2021 Jul; 146(13-14):899-903.Spiekermann K, Subklewe M, … von Bergwelt-Baildon M
  • Infection with SARS-CoV-2 has a profound influence on the hematopoetic system that mediates clinical symptoms and mortality. Several studies have shown that treatment of the cytokine storm (CRS) with anti-inflammatory drugs like dexamethasone and tocilizumab can significantly improve survival. Systematic reviews confirm the safety of convalescent plasma administration and offer initial indication…
  • Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms. [Review]
    Exp Mol Med. 2021 Jul 12 [Online ahead of print]Kang S, Kishimoto T
  • Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms. In this review, we present the current understanding of the diverse roles of IL-6, its receptors, and its signaling during acute severe systemic inflammation. IL-6 directly affects vascular endothelial cells, which produce several typ…
  • Tocilizumab as a Treatment for 'Cytokine Storm Syndrome' in COVID-19: A Case Report. [Case Reports]
    Acta Med Indones. 2021 Apr; 53(2):194-201.Syam AF, Pitoyo CW, … Makmun D
  • Coronavirus disease 19 (COVID-19) which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been a problem worldwide, particularly due to the high rate of transmission and wide range of clinical manifestations. Acute respiratory distress syndrome (ARDS) and multiorgan failure are the most common events observed in severe cases and can be fatal. Cytokine storm syndrome e…
  • Contemporary narrative review of treatment options for COVID-19. [Review]
    Respirology. 2021 08; 26(8):745-767.Shang L, Lye DC, Cao B
  • The coronavirus disease 2019 (COVID-19) pandemic is ongoing and many drugs have been studied in clinical trials. From a pathophysiological perspective, anti-viral drugs may be more effective in the early stage while immunomodulators may be more effective in severe patients in later stages of infection. While drugs such as lopinavir-ritonavir, hydroxychloroquine and azithromycin have proved to be …
  • Efficacy of tocilizumab in COVID-19: A review of the current evidence. [Comment]
    Sci Prog. 2021 Jul-Sep; 104(3):368504211030372.Alam W, Bizri AR
  • As cases of coronavirus 2019 (COVID-19) keep rising, reported deaths are increasing. Public health measures have been implemented with mixed efficacy. As vaccines are becoming more widely available and accessible globally, treating critically ill COVID-19 patients remains an issue with only dexamethasone found to be therapeutically effective to date. However, trials studying the efficacy of IL-6 …
  • COVID-19 Post-Infectious Encephalitis Presenting With Delirium as an Initial Manifestation. [Case Reports]
    J Investig Med High Impact Case Rep. 2021 Jan-Dec; 9:23247096211029787.Hara M, Kouda K, … Nakajima H
  • We report the case of a 65-year-old man with COVID-19 (coronavirus disease-2019) post-infectious encephalitis who presented with delirium as an initial manifestation. He had severe COVID-19 pneumonia and recovered with dexamethasone and tocilizumab. One week after discharge, he developed abnormal behavior and delirium without fever and respiratory symptoms. Brain magnetic resonance imaging showed…
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