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8,364 results
  • A double-edged sword: does highly active antiretroviral therapy contribute to syphilis incidence by impairing immunity to Treponema pallidum? [Review]
  • STSex Transm Infect 2017 Jan 16
  • Rekart ML, Ndifon W, … Cameron CE
  • CONCLUSIONS: Since rising syphilis incidence appears to have outpaced gonorrhoea and chlamydia, predominantly affecting HIV-1 positive MSM, behavioural factors alone may be insufficient to explain the unique, sharp increase in syphilis incidence. HAART agents have the potential to alter the innate and acquired immune responses in ways that may enhance susceptibility to T. pallidum. This raises the possibility that therapeutic and preventative HAART may inadvertently increase the incidence of syphilis, a situation that would have significant and global public health implications. We propose that additional studies investigating the interplay between HAART and enhanced T. pallidum susceptibility are needed. If our hypothesis is correct, HAART should be combined with enhanced patient management including frequent monitoring for pathogens such as T. pallidum.
  • Serum microRNA profiles in patients with syphilis. [Journal Article]
  • JEJ Eur Acad Dermatol Venereol 2017 Jan 12
  • Lu P, Fang C, … Yang B
  • Syphilis is an acute and chronic inflammatory disorder caused by the non-cultivatable spirochete Treponema pallidum subsp. pallidum (T. pallidum).(1,2) T. pallidum does not produce any known toxic pr...
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