- The effect of maternal HIV status and treatment duration on body composition of HIV-exposed and HIV-unexposed preterm, very and extremely low-birthweight infants. [Journal Article]
- PIPaediatr Int Child Health 2018 May 23; :1-12
- CONCLUSIONS: Mothers receiving HAART could have increased risk of preterm delivery, and the duration of maternal HAART affects postnatal body composition of their infants. Body composition differs between HIV-exposed and HIV-unexposed preterm infants.
- SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. [Journal Article]
- AAtherosclerosis 2018 Apr 30; 274:172-181
- CONCLUSIONS: We identified a novel SIRT1 activator E1231 and elucidated its beneficial effects on lipid and cholesterol metabolism. Our study suggests that E1231 might be developed as a novel drug for treating atherosclerosis.
- Effect of a 1-year elastic band resistance exercise program on cardiovascular risk profile in postmenopausal women. [Journal Article]
- MMenopause 2018 May 21
- CONCLUSIONS: One year of progressive resistance training with elastic bands has beneficial effects on anti-inflammatory and anthropometric cardiovascular risk factors in menopausal women, including changes in lipid profile.
- Gestational dyslipidaemia and adverse birthweight outcomes: a systematic review and meta-analysis. [Review]
- ORObes Rev 2018 May 21
- CONCLUSIONS: This meta-analysis suggested that the potential under-recognized adverse effects of intrauterine exposure to maternal dyslipidaemia may warrant further investigation into the relationship between maternal dyslipidaemia and birthweight in large prospective cohorts or in randomized trials.
- Trpc6 inactivation confers protection in a model of severe nephrosis in rats. [Journal Article]
- JMJ Mol Med (Berl) 2018 May 22
- Mutations in canonical transient receptor potential-6 (TRPC6) channels give rise to rare familial forms of focal and segmental glomerulosclerosis (FSGS). Here we examined a possible role for TRPC6 in...
Mutations in canonical transient receptor potential-6 (TRPC6) channels give rise to rare familial forms of focal and segmental glomerulosclerosis (FSGS). Here we examined a possible role for TRPC6 in the progression of chronic puromycin aminonucleoside (PAN) nephrosis in Sprague-Dawley rats, a classic model of acquired nephrotic syndromes. We used CRISPR/Cas9 technology to delete a 239-bp region within exon 2 of the Trpc6 gene (Trpc6del allele). Trpc6del/del rats expressed detectable Trpc6 transcripts missing exon 2, and TRPC6 proteins could be detected by immunoblot of renal cortex. However, the abundance of Trpc6 transcripts and TRPC6 protein in renal cortex was much lower than in Trpc6wt/wt littermates, and functional TRPC6 channels could not be detected in whole-cell recordings from glomerular cells cultured from Trpc6del/del animals, possibly because of disruption of ankyrin repeats 1 and 2. During the chronic phase of PAN nephrosis, Trpc6del/del rats had reduced urine albumin excretion, reduced serum cholesterol and triglycerides, and improved azotemia compared to wild-type Trpc6wt/wt littermates. Glomerulosclerosis was severe during chronic PAN nephrosis in Trpc6wt/wt rats but was markedly reduced in Trpc6del/del littermates. Trpc6del/del animals also had less severe tubulointerstitial fibrosis as assessed by several biochemical and histological analyses, as well as reduced foot process effacement and glomerular basement thickening compared to Trpc6wtt/wt controls. None of the manipulations in this study affected the abundance of TRPC5 channels in renal cortex. TRPC3 was increased in PAN nephrosis and in Trpc6del/del rats. These data support a role for TRPC6 channels in driving an acquired form of secondary FSGS.
- [CERULOPLASMIN CORRECTION OF DYSLIPIDEMIA CAUSED BY CHRONIC PHYSICAL LOAD IN EXPERIMENT AT SUBMAXIMAL POWER.] [Journal Article]
- EKEksp Klin Farmakol 2016; 79(6):9-11
- Chronic submaximal physical load of aerobic-anaerobic charater leads to pro-atherogenic dyslipidemia, as manifested by increased levels of triglycerides, total cholesterol, and very-low-density lipop...
Chronic submaximal physical load of aerobic-anaerobic charater leads to pro-atherogenic dyslipidemia, as manifested by increased levels of triglycerides, total cholesterol, and very-low-density lipoproteins. Ceruloplasmin (total dose 60 mg/kg body weight, triple intraperitoneal introduction on the 1st, 3rd, and 5th day of experiment) produced a partial correction of dyslipidemia, manifested by restoration of the normal levels of triglycerides, total cholesterol, and lipoproteins of very low, low, and high density. At the same time, ceruloplasmin administration did not influence the level of phospholipids.
- Influence of risk factors on insulin resistance in patients with overweight and obesity. [Journal Article]
- WLWiad Lek 2018; 71(3 pt 1):558-560
- CONCLUSIONS: Conclusions: We assume that modification of lifestyle and individual approach to pharmacologic correction of dyslipidemia in overweight and obese patients help to avoid the development of insulin resistance, which is a predictor of type 2 diabetes mellitus.
- Different regulation of cortisol and corticosterone in the subterranean rodent Ctenomys talarum: responses to dexamethasone, angiotensin II, potassium, and diet. [Journal Article]
- GCGen Comp Endocrinol 2018 May 18
- When harmful environmental stimuli occur, glucocorticoids (GCs), cortisol and corticosterone are currently used to evaluate stress status in vertebrates, since their secretions are primarily associat...
When harmful environmental stimuli occur, glucocorticoids (GCs), cortisol and corticosterone are currently used to evaluate stress status in vertebrates, since their secretions are primarily associated to an increased activity of the hypothalamic-pituitary-adrenal (HPA) axis. To advance in our comprehension about GCs regulation, we evaluated the subterranean rodent Ctenomys talarum to assess cortisol and corticosterone response to (1) the negative feedback of the HPA axis using the dexamethasone (DEX) suppression test, (2) angiotensin II (Ang II), (3) potassium (K+) intake, and (4) different diets (vegetables, grasses, acute fasting). Concomitantly, several indicators of individual condition (body mass, neutrophil to lymphocyte ratio, blood glucose, triglycerides and hematocrit) were measured for diet treatments. Results confirm the effect of DEX on cortisol and corticosterone in recently captured animals in the field but not on corticosterone in captive animals. Data suggest that Ang II is capable of stimulating corticosterone, but not cortisol, secretion. Neither cortisol nor corticosterone were responsive to K+ intake. Cortisol levels increased in animals fed with grasses in comparison to those fed with vegetables while corticosterone levels were unaffected by diet type. Moreover, only cortisol responded to fasting. Overall, these results confirm that cortisol and corticosterone are not interchangeable hormones in C. talarum.
- Excessive Erythrocytosis and Cardiovascular Risk in Andean Highlanders. [Journal Article]
- HAHigh Alt Med Biol 2018 May 21
- Cardiovascular diseases are the main cause of death worldwide. Life under high-altitude (HA) hypoxic conditions is believed to provide highlanders with a natural protection against cardiovascular and...
Cardiovascular diseases are the main cause of death worldwide. Life under high-altitude (HA) hypoxic conditions is believed to provide highlanders with a natural protection against cardiovascular and metabolic diseases compared with sea-level inhabitants. However, some HA dwellers become intolerant to chronic hypoxia and develop a progressive incapacitating syndrome known as chronic mountain sickness (CMS), characterized by excessive erythrocytosis (EE; Hb ≥21 g/dL in men, Hb ≥19 g/dL in women). Evidence from HA studies suggests that, in addition to CMS typical signs and symptoms, these highlanders may also suffer from metabolic and cardiovascular disorders. Thus, we hypothesize that this syndrome is also associated to the loss of the cardiometabolic protection observed in healthy highlanders (HH), and therefore to a higher cardiovascular risk (CVR). The aim of the present work was to evaluate the association between EE and CVR calculated using the Framingham General CVR Score and between EE and CVR factors in male highlanders. This cross-sectional study included 342 males from Cerro de Pasco, Peru at 4340 m (HH = 209, CMS = 133). Associations were assessed by multiple logistic regressions adjusted for potential confounders (BMI, pulse oxygen saturation and age). The adjusted models show that the odds of high CVR (>20%) in highlanders with EE was 3.63 times the odds in HH (CI 95%:1.22-10.78; p = 0.020), and that EE is associated to hypertension, elevated fasting serum glucose, insulin resistance, and elevated fasting serum triglycerides. Our results suggest that individuals who suffer from EE are at increased risk of developing cardiovascular events compared with their healthy counterparts.
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- Exercise Periodization over the Year Improves Metabolic Syndrome and Medication Use. [Journal Article]
- MSMed Sci Sports Exerc 2018 May 02
- CONCLUSIONS: Two yearly 16-week HIIT programs are enough exercise to chronically lower MetS while preventing the reductions in CRF associated to aging. Of clinical relevance, yearly exercise training halts the increase in medicine use that occurs in non-exercising MetS individuals.ClinicalTrials.gov identifierNCT03019796.