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(Tuberculosis)
256,829 results
  • Discovery of napabucasin derivatives for the treatment of tuberculosis. [Journal Article]
    Medchemcomm 2019; 10(9):1635-1640Li C, Tang Y, … Luo Y
  • Tuberculosis is the contagious disease responsible for the highest number of deaths worldwide. Here, we screened a commercially available compound library and found napabucasin to possess a moderate anti-tubercular activity against M. tuberculosis H37Ra (MIC 2.5 μg mL-1, 10.4 μM). Three series of napabucasin derivatives were further evaluated for their in vitro anti-tubercular activities against …
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