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246 results
  • A Deep Learning-Based Approach for Gait Analysis in Huntington Disease. [Journal Article]
    Stud Health Technol Inform 2019; 264:477-481Zhang S, Poon SK, … Loy CT
  • Huntington Disease (HD) is a genetic neurodegenerative disease which leads to involuntary movements and impaired balance. These changes have been quantified using footstep pressure sensor mats such as Protokinetics' Zeno Walkway. Drawing from distances between recorded footsteps, patients' disease severity have been measured in terms of high level gait characteristics such as gait width and strid…
  • Obsessive-Compulsive Symptoms are Less Common in Huntington's Disease than Reported Earlier. [Journal Article]
    J Huntingtons Dis 2019; 8(4):493-500Hoffmann R, Schröder N, … Saft C
  • CONCLUSIONS: OC symptoms in pre-HD occur not more often than in general population. The HZI appears to be useful for examining OC symptoms in detail in pre-HD and HD. HZI-subscale ratings for washing and cleaning compulsions were less pronounced in HD compared to OCD patients, possibly due to loss of disgust. The SCL-90-R might overestimate OC symptoms in both groups.
  • Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study. [Journal Article]
    Psychiatry Res Neuroimaging 2019; 291:1-8Wilkes FA, Abaryan Z, … Georgiou-Karistianis N
  • We aimed to investigate the relationship between striatal morphology in Huntington disease (HD) and measures of motor and cognitive dysfunction. MRI scans, from the IMAGE-HD study, were obtained from 36 individuals with pre-symptomatic HD (pre-HD), 37 with early symptomatic HD (symp-HD), and 36 healthy matched controls. The neostriatum was manually segmented and a surface-based parametric mapping…
  • Comparison of the Huntington's Disease like 2 and Huntington's Disease Clinical Phenotypes. [Journal Article]
    Mov Disord Clin Pract 2019; 6(4):302-311Anderson DG, Ferreira-Correia A, … Krause A
  • CONCLUSIONS: The HDL2 phenotype is similar to HD and is initially characterized by dementia, chorea, and oculomotor abnormalities, progressing to a rigid and bradykinetic state, suggesting the UHDRS is useful to monitor disease progression in HDL2. Although HDL2 patients scored higher on some UHDRS domains, this did not differentiate between the two diseases; it may however be emerging evidence of HDL2 having a more severe clinical phenotype.
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