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1,593 results
  • HLA-G Polymorphisms Are Associated with Non-segmental Vitiligo among Brazilians. [Journal Article]
    Biomolecules 2019; 9(9)Veiga-Castelli L, Oliveira ML, … Mendes-Junior C
  • CONCLUSIONS: It remains unclear whether the HLA-G variants associated with vitiligo were detected because of the high linkage disequilibrium (LD) with HLA-A*02, or if the HLA-A variants previously reported as associated with vitiligo were detected because of the high LD with HLA-G*01:01:01:01/UTR-1, or if both genes jointly contribute to vitiligo susceptibility.
  • Congenital Uterine Malformation by Experts (CUME): T-shaped uterus. [Journal Article]
    Ultrasound Obstet Gynecol 2019Ludwin A, Coelho Neto MA, … Martins WP
  • CONCLUSIONS: The diagnostic of T-shaped uterus is not easy and the agreement among top-experts is only moderate, and single expert judgment is commonly insufficient for accurate diagnosis. The study has identified three measurements with cut-offs that had good diagnostic test accuracy and fair to moderate reliability (lateral indentation depth ≥ 7 mm, lateral indentation angle ≤ 130° and T-angle ≤ 40°), and when applicated together they have provided high post-test probability of this condition. Based on the CUME criteria of T-shaped uterus, the prevalence, clinical implication and the management, as well as assessment of post-surgical morphologic outcomes of this condition may be determined with enough accuracy, reliability and with a known probability of disease after negative and positive test results. The CUME definition of T-shape uterus may help on the development of interventional randomized controlled trials, observational studies, and diagnostics of uterine morphology in every day practice, and therefore could be adopted by guidelines on uterine anomalies to enrich their classification systems. This article is protected by copyright. All rights reserved.
  • Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination. [Journal Article]
    Proc Natl Acad Sci U S A 2019; 116(34):17121-17126de Lima DS, Cardozo LE, … Nakaya HI
  • Understanding the mechanisms of vaccine-elicited protection contributes to the development of new vaccines. The emerging field of systems vaccinology provides detailed information on host responses to vaccination and has been successfully applied to study the molecular mechanisms of several vaccines. Long noncoding RNAs (lncRNAs) are crucially involved in multiple biological processes, but their …
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