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563 results
  • In silico Inhibition of BACE-1 by Selective Phytochemicals as Novel Potential Inhibitors: Molecular Docking and DFT Studies. [Journal Article]
  • CDCurr Drug Discov Technol 2019 Feb 14
  • Arif N, Subhani A, … Rasool N
  • CONCLUSIONS: Out of seven phytochemicals, four are from plant Glycyrrhiza glabra i.e. Shinflavanone, Glabrolide, Glabrol and PrenyllicoflavoneA, one from Huperzia serrate i.e. Macleanine, one from Uncaria rhynchophylla i.e. 3a-dihydro-cadambine and another one is VolvalerelactoneB from plant Valeriana-officinalis. It is concluded that these phytochemicals are candidate for drug/inhibitor against BACE-1, and can be administered to humans after experimental validation through in vitro and in vivo trials.
  • Phenolic plant extracts are additive in their effects against in vitro ruminal methane and ammonia formation. [Journal Article]
  • AJAsian-Australas J Anim Sci 2019 Jan 02
  • Sinz S, Marquardt S, … Kreuzer M
  • CONCLUSIONS: The study identified methane and ammonia mitigating potential of various phenolic plant extracts and showed a number of additive and some non-linear effects of combinations of extracts. Further studies, especially in live animals, should concentrate on combinations of extracts from grape seed, green tea leaves and acacia bark and determine the ideal dosages of such combinations for purpose of methane mitigation.
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