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574 results
  • Isorhynchophylline enhances Nrf2 and inhibits MAPK pathway in cardiac hypertrophy. [Journal Article]
    Naunyn Schmiedebergs Arch Pharmacol 2019Zhang Y, Cui Y, … Guo H
  • Isorhynchophylline (IRN) is one of the major tetracyclic oxindole alkaloids found in Uncaria rhynchophylla. Studies have found that IRN has diverse biological activities including antioxidant, anti-apoptosis, and neuroprotection. However, little is known about the effect of IRN on the development of cardiac hypertrophy. In this study, we investigated the change of the cell surface area and nascen…
  • Polyphenolic Composition and Antioxidant Activity of Uncaria tomentosa Commercial Bark Products. [Journal Article]
    Antioxidants (Basel) 2019; 8(9)Navarro M, Arnaez E, … Monagas M
  • Uncaria tomentosa, which is widely commercialized as an herbal medicine, constitutes an important source of secondary metabolites with diverse biological activities. For instance, we have previously reported, for the first time, of a polyphenolic profile rich in proanthocyanidins from extracts of U. tomentosa plants, as well as their antioxidant capacity, antimicrobial activity on aerial bacteria…
  • Unnatural spirocyclic oxindole alkaloids biosynthesis in Uncaria guianensis. [Journal Article]
    Sci Rep 2019; 9(1):11349Lopes AA, Chioca B, … Pereira AMS
  • Spiro-oxindole scaffolds have been studied due to their promising therapeutic potential. In the Amazon rainforest there are two important Uncaria species known as "cat's claw", which biosynthesize spirocyclic oxindole alkaloids; Uncaria tomentosa (Willd. ex Schult.) DC. and Uncaria guianensis (Aublet) Gmell. We carried out a precursor-directed biosynthesis approach with U. guianensis and successf…
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