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Unbound Medicine.
(VALPROATES)
42 results
  • 120th Anniversary of the Kraepelinian Dichotomy of Psychiatric Disorders. [Historical Article]
    Curr Psychiatry Rep. 2019 07 01; 21(8):65.Rybakowski JK
  • Emil Kraepelin, in 1899, proposed a dichotomy of psychiatric disorders into "dementia praecox," further called schizophrenia, and "manisch-depressives Irresein," now conceptualized as a bipolar disorder. The purpose of the review is to show both similarities and differences between disorders involved in this dichotomy, speaking for and against the idea.
  • Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes. [Review]
    Ann Pharmacother. 2019 06; 53(6):603-611.Chen JW, Borgelt LM, Blackmer AB
  • CONCLUSIONS: This is the first cannabis-derived medication with approval from the US Food and Drug Administration. This CBD formulation significantly reduces seizures as an adjunct to standard antiepileptic therapies in patients ≥2 years old with DS and LGS and is well tolerated.
  • [Depakine: 25 years in Russia]. [Review]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2017; 117(11):129-134.Karlov VA
  • The article summarizes domestic and international studies on the development and clinical investigation of valproates including multiple studies of a research team directed by the author. Valproate targets are considered in biological and clinical aspects. A spectrum of action and advantages of the brand drug (depakine) compared to generics and other antiepileptic drugs are discussed. A number of…
  • [Algorithms of using valproic acid drugs in women]. [Review]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2015; 115(4):36-40.Vlasov PN
  • Characteristics of using valproic acid drugs in women, from puberty to menopause period, are reviewed. Based on initial treatment efficacy, type of epileptic seizures and a form of epilepsy, the author emphasizes the practical use of valproates during pregnancy in dependence on the situation. Several scenarios of pregnancy course and possible treatment tactics are presented.
  • [Antiepileptic drugs and seizure aggravation]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2014; 114(11 Pt 2):32-36.Kotov AS
  • CONCLUSIONS: Different AEDs can cause aggravation. Seizures aggravation after generic substitution was characteristic of TPM most frequently. Seizure aggravation with different AEDs and due to increasing the dose of AEDs was associated with poor outcome. In all cases, seizure aggravation was more frequently caused by LTG (4.7%), CBZ (3.7%) and TPM (3.3%). To reduce the risk of aggravation, slow AEDs titration and keeping a diary of seizures are required.
  • The transcriptional activator Ino2p dissociates from the yeast INM1 promoter in induction. [Journal Article]
    DNA Cell Biol. 2014 Dec; 33(12):863-8.Zhang L, Di J
  • Mood stabilizers lithium and valproates are widely used in the treatment of bipolar disorder. It has been shown that these drugs can affect the inositol monophosphatase activity and thus the inositol de novo biosynthesis. However, the molecular mechanism of this action has thus far been vague. As such, characterizing the regulation of the gene encoding inositol monophosphatase at the molecular le…
  • [Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2013; 113(11):34-9.Avakian GN, Oleĭnikova OM, … Avakian GG
  • We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49). The seasonal distribution of number and severity of seizures assessed with the NHS3 scale in dependence of Cmin and Cmax content of antiepileptic drugs carbamazepine and valproates in the serum of patients was estimated. There was a significant increase in the number of seizures an…
  • [A paradoxical reaction on valproates in a female patient with juvenile absence epilepsy]. [Case Reports]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2013; 113(4 Pt 2):66-70.Karlov VA, Geĭbatova LG
  • A case of a female patient with juvenile absence epilepsy who developed generalized seizures after the treatment with valproic acid preparations is described. The further choice of antiepileptic treatment for this patient revealed that carbamazepine (finlepsin retard) and lamotrigine were effective for stopping generalized seizures and absences, respectively.
  • Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge. [Review]
    CNS Drugs. 2013 Mar; 27(3):165-73.Rybakowski JK
  • Mood stabilizers form a cornerstone in the long-term treatment of bipolar disorder. The first representative of their family was lithium, still considered a prototype drug for the prevention of manic and depressive recurrences in bipolar disorder. Along with carbamazepine and valproates, lithium belongs to the first generation of mood stabilizers, which appeared in psychiatric treatment in the 19…
  • [Efficacy of epilepsy treatments with different drugs]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(9):37-40.Kotov AS, Belova IuA
  • We studied 479 epileptic patients. The study included the evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, MRI of the brain. The period of observation was 1-8 years (on average 2.5 years). Idiopathic generalized epilepsy was diagnosed in 55 cases, cryptogenic focal epilepsy in 228 cases and symptomatic focal epilepsy in 196 cases. In the end…
  • [Idiopathic generalized epilepsy in young women: choise of treatment strategy]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(6 Pt 2):45-8.Kotov AS
  • We studied 279 women, aged 18-40 years old, with epilepsy. The study included the evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, MRI of the brain. The period of observation was 6 months - 8 years. Idiopathic generalized epilepsy (IGE) was diagnosed in 85 cases, cryptogenic focal epilepsy in 107 cases, symptomatic focal epilepsy in 51 cases…
  • [Complex therapy of idiopathic forms of epilepsy with small doses of valproates and levetiracetam]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2012; 112(6 Pt 2):37-9.Karlov VA, Freĭdkova NV, Rusanova LV
  • A combination of valproates in dose 15-25 mg per day and levetiracetam in dose 20-25 mg per day was used in the treatment of 23 patients with different forms of epilepsy (juvenile myoclonic epilepsy, juvenile absence epilepsy, convulsive idiopathic generalized epilepsy and children absence epilepsy). The use of these drugs was effective in all forms of epilepsy. There were positive changes in the…
  • [Transitory cognitive dysfunction in rolandic epilepsy]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2011; 111(10 Pt 2):63-7.Ermolenko NA, Ermakov AIu, … Buchneva IA
  • Forty-four patients with rolandic epilepsy (32 boys, 12 girls), aged from 5 to 14 years, were examined in the prospective study during 5 years. Before the antiepileptic treatment, most of patients had transitory cognitive disturbances. There were the impairment of verbal functions, especially verbal intellect, while non-verbal intellect remained intact; dyspraxia, impairment of auditory-speech me…
  • [Stereotactic radiosurgery in treatment of patients with hypothalamic hamartomas]. [Journal Article]
    Zh Vopr Neirokhir Im N N Burdenko. 2010 Jan-MarGolanov AV, Kornienko VN, … Sorokin VA
  • Hypothalamic hamartoma (HH) is malformation of the brain manifesting by paroxysmal disorders (gelastic seizures) and endocrine disorders (mostly precocious sexual development). Surgical resection of HH is associated with the risk of severe neurological and neuroendocrine complications. Alternative ways of treatment are being investigasted. Stereotactic radiosurgery is one of the leading technique…
  • Monotherapy of epilepsy in women: psychiatric and neuroendocrine aspects. [Clinical Trial]
    Neurosci Behav Physiol. 2010 Feb; 40(2):157-62.Zheleznova EV, Kalinin VV, … Medvedev IL
  • The aim of the present work was to perform a comparative assessment of the efficacy and safety of traditional and contemporary antiepileptic agents in women of reproductive age. The experimental group consisted of 65 patients, of whom 48 had partial epilepsy and 17 had idiopathic generalized epilepsy. A number of issues were addressed in studies of a larger group of patients (110), including both…
  • [Fetal malformations in women with epilepsy]. [Journal Article]
    Akush Ginekol (Sofiia). 2009; 48(1):16-21.Bozhinov P, Bozhinova C, Markova C
  • CONCLUSIONS: This study shows that all pregnant women with epilepsy should be carefully followed during their period of pregnancy with the help of echocardiography, biochemistry and if it's necessary--amniocenteses. We should inform every pregnant woman with epilepsy for the benefits and risks of the long-term therapy with antiepileptic drugs.
  • [Monotherapy of epilepsy in women: psychiatric and neuroendocrine aspects]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2008; 108(10):43-8.Zheleznova EV, Kalinin VV, … Medvedev IL
  • An aim of the study was a comparative evaluation of efficacy and safety of traditional and modern antiepileptic drugs in women of reproductive age. A main group of patients consisted of 65 women, including 48 patients with partial epilepsy and 17 - with idiopathic generalized epilepsy. Some issues are solved in the study of a larger group comprising 110 patients (65 female and 45 male). The follo…
  • [Clinical polymorphism of malignant epilepsy of infancy with migrating multifocal seizures (8 cases)]. [Case Reports]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2008; Suppl 3:8-21.Petrukhin AS, Kholin AA, … Mukhin KIu
  • Malignant migrating partial seizures in infancy are rare epilepsy syndrome that begins in the first 6 months of life and characterized by multiple continuous electroencephalographic and electroclinical focal ictal patterns which involved different independent areas of both hemispheres with arrest of psychomotor development. The present detailed review is based on the personal observation of 8 pat…
  • [West syndrome: clinico-electro-anatomical characteristics and a differential therapeutical approach]. [Multicenter Study]
    Zh Nevrol Psikhiatr Im S S Korsakova. 2008; Suppl 2:68-77.Kholin AA, Il'ina ES, … Petrukhin AS
  • One hundred and thirty children with West syndrome, aged 1.5 months-2 years, were studied. The symptomatic form of West syndrome was diagnosed in 95.4% of cases. The prenatal etiological factors were observed in 57% of patients. Different variants of hypsarrhythmia at EEG were revealed in 87%. The percentage of cases with typical and modified hypsarrhythmia was 13.3% and 86.7%, respectively. The …
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