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42 results
  • 120th Anniversary of the Kraepelinian Dichotomy of Psychiatric Disorders. [Review]
    Curr Psychiatry Rep 2019; 21(8):65Rybakowski JK
  • Emil Kraepelin, in 1899, proposed a dichotomy of psychiatric disorders into "dementia praecox," further called schizophrenia, and "manisch-depressives Irresein," now conceptualized as a bipolar disorder. The purpose of the review is to show both similarities and differences between disorders involved in this dichotomy, speaking for and against the idea.
  • [Depakine: 25 years in Russia]. [Review]
    Zh Nevrol Psikhiatr Im S S Korsakova 2017; 117(11):129-134Karlov VA
  • The article summarizes domestic and international studies on the development and clinical investigation of valproates including multiple studies of a research team directed by the author. Valproate targets are considered in biological and clinical aspects. A spectrum of action and advantages of the brand drug (depakine) compared to generics and other antiepileptic drugs are discussed. A number of…
  • [Algorithms of using valproic acid drugs in women]. [Review]
    Zh Nevrol Psikhiatr Im S S Korsakova 2015; 115(4):36-40Vlasov PN
  • Characteristics of using valproic acid drugs in women, from puberty to menopause period, are reviewed. Based on initial treatment efficacy, type of epileptic seizures and a form of epilepsy, the author emphasizes the practical use of valproates during pregnancy in dependence on the situation. Several scenarios of pregnancy course and possible treatment tactics are presented.
  • [Antiepileptic drugs and seizure aggravation]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova 2014; 114(11 Pt 2):32-36Kotov AS
  • CONCLUSIONS: Different AEDs can cause aggravation. Seizures aggravation after generic substitution was characteristic of TPM most frequently. Seizure aggravation with different AEDs and due to increasing the dose of AEDs was associated with poor outcome. In all cases, seizure aggravation was more frequently caused by LTG (4.7%), CBZ (3.7%) and TPM (3.3%). To reduce the risk of aggravation, slow AEDs titration and keeping a diary of seizures are required.
  • The transcriptional activator Ino2p dissociates from the yeast INM1 promoter in induction. [Journal Article]
    DNA Cell Biol 2014; 33(12):863-8Zhang L, Di J
  • Mood stabilizers lithium and valproates are widely used in the treatment of bipolar disorder. It has been shown that these drugs can affect the inositol monophosphatase activity and thus the inositol de novo biosynthesis. However, the molecular mechanism of this action has thus far been vague. As such, characterizing the regulation of the gene encoding inositol monophosphatase at the molecular le…
  • [Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy]. [Journal Article]
    Zh Nevrol Psikhiatr Im S S Korsakova 2013; 113(11):34-9Avakian GN, Oleĭnikova OM, … Avakian GG
  • We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49). The seasonal distribution of number and severity of seizures assessed with the NHS3 scale in dependence of Cmin and Cmax content of antiepileptic drugs carbamazepine and valproates in the serum of patients was estimated. There was a significant increase in the number of seizures an…
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