- Uterine Lipoleiomyoma and Lipoma: A Rare Unique Case Report with Review of Literature. [Journal Article]
- IJInt J Appl Basic Med Res 2018 Jul-Sep; 8(3):193-195
- Uterine lipoleiomyoma and pure lipoma are uncommon and extremely rare benign lipomatous tumors. Reported incidence is 0.03%-0.25%. Pure cervical lipoma is exceptionally rare. These tumors commonly ar...
Uterine lipoleiomyoma and pure lipoma are uncommon and extremely rare benign lipomatous tumors. Reported incidence is 0.03%-0.25%. Pure cervical lipoma is exceptionally rare. These tumors commonly arise in postmenopausal women. Ultrasonography and computed tomography finding may be nonspecific. Although magnetic resonance imaging can be useful in identifying the fatty nature of the lesion preoperatively, most of the cases postoperatively on histopathological examination. Although various theories of histogenesis of these tumors have been proposed, histogenesis remains to be enigma. These lesions may have coexistent malignancy in uterus, ovaries, and fallopian tubes or may have other metabolic disorders and abnormal estrogen status. Immunohistochemical studies have played an integral role in understanding its complex histogenesis. We did not find any case study in medical literature in which uterine lipoleiomyoma and cervical lipoma have been described in hysterectomy specimen. We report a unique case of a 43-year-old premenopausal woman with complaints of irregular vaginal bleeding and lower abdomen pain. Lipoleiomyoma in uterus corpus and cervical lipoma were diagnosed in hysterectomy specimen.
- Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review. [Journal Article]
- MMedicine (Baltimore) 2018; 97(33):e11838
- CONCLUSIONS: The diagnosis of postmenopausal ovarian YST is relatively difficult and it can coexist with other germ cell or epithelial tumors. Postmenopausal ovarian YSTs are aggressive, and may have a worse prognosis compared with those in young patients. More aggressive treatment is needed. When YST mixed with epithelial cancer components, adjuvant chemotherapy regimen should include platinum-based chemotherapy aiming at both epithelial ovarian cancer and germ cell tumors.
- Metastatic Squamous Cell Carcinoma versus Primary High Grade Serous Carcinoma of the Ovary. [Journal Article]
- JCJ Coll Physicians Surg Pak 2018; 28(8):648-650
- We report an extremely rare case of abnormal vaginal bleeding in a 66-year postmenopausal woman. A sterile speculum examination revealed no obvious tumour mass in the cervix. Serum levels of cancer a...
We report an extremely rare case of abnormal vaginal bleeding in a 66-year postmenopausal woman. A sterile speculum examination revealed no obvious tumour mass in the cervix. Serum levels of cancer antigen 125 and carcinoembryonic antigen were elevated at 480.3 IU/L and 19.3 ng/ml, respectively. Ultrasound showed a 4 × 3 × 2 cm hypoechoic solid mass on the left uterine adnexa, a 4-5 cm mass in the right adnexa, a 4 cm mass in the vesicouterine excavation and a 4-5 cm mass in the omentum. Finally, debulking surgery with tumour resection was performed. The bilateral ovarian tumours showed an infiltrative pattern of stromal invasion. Lymphovascular tumour emboli were present in bilateral ovaries. A careful histological examination revealed an eosinophilic cytoplasm that focally formed pear-like structures in the local area of the left ovary. Immunochemical analysis aided in the diagnosis of cervical squamous cell carcinoma involving the ovaries, fallopian tubes, uterine serosa, vesicouterine excavation, mesoappendix, mesentery, omentum, and paracolic sulcus. She was treated with surgery followed by cisplatin-based combination chemotherapy.
- Spontaneous Ruptured Pyomyoma in a Nulligravid Female: A Case Report and Review of the Literature. [Journal Article]
- CRCase Rep Obstet Gynecol 2018; 2018:1026287
- Pyomyoma, or suppurative leiomyoma, is a rare complication of uterine fibroids. It occurs most commonly in the setting of pregnancy, the immediate postpartum period, or postmenopausal status. It may ...
Pyomyoma, or suppurative leiomyoma, is a rare complication of uterine fibroids. It occurs most commonly in the setting of pregnancy, the immediate postpartum period, or postmenopausal status. It may also arise after recent uterine instrumentation, after uterine artery embolization, or in immunocompromised patients. The most likely cause of pyomyoma is vascular compromise followed by bacterial seeding from direct, hematogenous, or lymphatic spread. Diagnosis is difficult, as the condition is rare, presents with vague symptoms, and is difficult to identify on imaging. Definitive diagnosis is only possible with surgery. Pathology shows a degenerating fibroid with hemorrhage, necrosis, cystic degeneration, and/or inflammatory change. Cultures of the pus contained within often show polymicrobial infection.
- Uterine Carcinosarcoma with Alpha-Fetoprotein-Producing Hepatoid Component: A Case Report and Literature Review. [Journal Article]
- CRCase Rep Pathol 2018; 2018:3972353
- A 67-year-old woman presented with postmenopausal vaginal bleeding. Full body imaging demonstrated an intrauterine mass with deep myometrial invasion but no nodal or other metastatic disease. Uterine...
A 67-year-old woman presented with postmenopausal vaginal bleeding. Full body imaging demonstrated an intrauterine mass with deep myometrial invasion but no nodal or other metastatic disease. Uterine curettage was performed. Histologically, the tumor was an endometrioid adenocarcinoma with sarcomatous element and a hepatoid component, the latter was immunohistochemically positive for alpha-fetoprotein, HepPar-1, and arginase-1. The patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Serum alpha-fetoprotein level decreased from 31896 ug/l preoperatively to 2063 ug/l postoperatively. Eight weeks later, a rise in serum alpha-fetoprotein was detected, and a biopsy-proven vaginal recurrence was diagnosed. Palliative chemotherapy led to tumor shrinkage and a concurrent decrease in the serum alpha-fetoprotein level. A rise in serum alpha-fetoprotein, refractory to second-line chemotherapy, was accompanied by subsequent development of ureteric obstruction, ascites, and radiological evidence of peritoneal metastases. This is an unusual case of uterine carcinosarcoma with an alpha-fetoprotein-producing hepatoid adenocarcinoma component. Serum alpha-fetoprotein level corresponds to disease recurrence and progression.
- Vaginal Bleeding as Initial Presentation of an Aggressive Renal Cell Carcinoma: A Case Report and Review of the Literature. [Journal Article]
- CRCase Rep Pathol 2018; 2018:2109279
- CONCLUSIONS: We report the first known case of vaginal metastasis as initial presentation of a renal cell carcinoma with rhabdoid features. Postmenopausal women with renal cell carcinoma who present with vaginal bleeding should undergo a thorough inspection of the vaginal wall for the potential of metastatic neoplasms.
- Comparison of UpholdTM Vaginal Mesh Procedure with Hysterectomy or Uterine Preservation for the Treatment of Pelvic Organ Prolapse. [Journal Article]
- SRSci Rep 2018 Jun 21; 8(1):9438
- Hysterectomy is the empirical treatment for female pelvic organ prolapse (POP) without robust evidence to prove its efficacy. Uphold transvaginal mesh (TVM) system is an innovated device with smaller...
Hysterectomy is the empirical treatment for female pelvic organ prolapse (POP) without robust evidence to prove its efficacy. Uphold transvaginal mesh (TVM) system is an innovated device with smaller area, superior anterior/apical support with single incision to treat POP. The prospective cohort study aims to evaluate Uphold TVM's performance with or without concomitant hysterectomy. Inclusion criteria specify patients suffering from stage 2 or more anterior/apical prolapse without previous hysterectomy. Exclusion criteria specify those with contraindications to uterine preservation, such as leiomyomas, adenomyosis, endometrial hyperplasia, abnormal uterine bleeding, postmenopausal bleeding, cervical dysplasia, receiving tamoxifen treatment, family history of gynecology cancer, or colon cancer and incapability to be routinely followed. Thirty patients are recruited in the hysterectomy group and 66 patients in the hysteropexy group. The results demonstrate that patients with Uphold mesh only experience longer vaginal length, shorter operation duration, less blood loss and less post-operation pain. The performance in anatomical correction, lower urinary tract symptoms improvement, de novo dyspareunia, urodynamic study parameters and mesh extrusion rates are comparable with or without uterus preservation. The information is useful in pre-operation counseling, when the patient can make an educated choice whether or not to receive concomitant hysterectomy.
- Endophytic-Type Endometrial Cancer with Adenomyosis Successfully Diagnosed with Hysteroscopic Endometrial Biopsy Using an 8.3-mm Operative Resectoscope: A Case Report. [Journal Article]
- CRCase Rep Oncol 2018 May-Aug; 11(2):311-317
- In order to diagnose endometrial cancer preoperatively, outpatient endometrial biopsy with a curette is frequently performed owing to its convenience. However, in some cases, gynecologists fail to di...
In order to diagnose endometrial cancer preoperatively, outpatient endometrial biopsy with a curette is frequently performed owing to its convenience. However, in some cases, gynecologists fail to diagnose endometrial cancer via outpatient endometrial biopsy because of the cancer's distribution in the uterus and its consistency. A 57-year-old Japanese woman (gravida 4 para 4) presented with a 6-month history of light but intermittent postmenopausal vaginal bleeding. A malignant uterine tumor was strongly suspected after imaging using ultrasound examination and magnetic resonance imaging; however, a precise pathological diagnosis was not achieved despite multiple outpatient endometrial biopsies with the aid of office hysteroscopy. Based on an endometrial biopsy obtained using a cutting loop electrode on an 8.3-mm operative resectoscope, we reached a diagnosis of endophytic-type endometrial cancer, which is in accordance with the final pathological diagnosis after abdominal hysterectomy. Three months after her first visit to our hospital, total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic/para-aortic lymph node dissection were performed. Macroscopically, the endometrium was atrophic, and there was no obvious mass in the uterine cavity; however, microscopically, the cancer cells mainly existed in the deep myometrium and the final diagnosis was International Federation of Gynecology and Obstetrics (FIGO) stage IB endometrial cancer. Operative biopsy of the uterine endometrium and deep myometrium using hysteroscopy confirmed an accurate preoperative diagnosis of uterine endometrial cancer specifically of the endophytic type.
- Inadequately Staged Endometrial Cancer: a Clinical Dilemma. [Journal Article]
- IJIndian J Surg Oncol 2018; 9(2):166-170
- Incidental diagnosis of carcinoma endometrium following hysterectomy requires clinical expertise from a gynecologic oncologist, with regard to subsequent management. We report our experience with com...
Incidental diagnosis of carcinoma endometrium following hysterectomy requires clinical expertise from a gynecologic oncologist, with regard to subsequent management. We report our experience with completion staging in endometrial cancer, to determine the benefits and risks of completion staging in women with posthysterectomy diagnosis of endometrial cancer.
New Search Next
- Rare case of undifferentiated uterine sarcoma with neuroectodermal differentiation and osteoclast-like giant cells. [Journal Article]
- TJTaiwan J Obstet Gynecol 2018; 57(3):442-446
- CONCLUSIONS: UUSs are rare high-grade tumors observed in elderly women. These women typically present with postmenopausal bleeding and extrauterine diseases and have a poor prognosis. Neuroectodermal differentiation in UUSs has a müllerian origin. The presence of OGCs may suggest a poor prognosis; however, further studies are necessary to determine the exact nature of such neoplasms.