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Unbound Medicine.
(Vaginitis and Vaginosis)
13,477 results
  • Gardnerella vaginalis clades in pregnancy: New insights into the interactions with the vaginal microbiome. [Journal Article]
    PLoS One. 2022; 17(6):e0269590.Severgnini M, Morselli S, … Marangoni A
  • Gardnerella vaginalis (GV) is an anaerobic bacterial species involved in the pathogenesis of bacterial vaginosis (BV), a condition of vaginal dysbiosis associated with adverse pregnancy outcomes. GV strains are categorized into four clades, characterized by a different ability to produce virulence factors, such as sialidase. We investigated the distribution of GV clades and sialidase genes in the…
  • Models of Murine Vaginal Colonization by Anaerobically Grown Bacteria. [Journal Article]
    J Vis Exp. 2022 05 25Morrill SR, Agarwal K, … Lewis AL
  • The mammalian vagina can be colonized by many bacterial taxa. The human vaginal microbiome is often dominated by Lactobacillus species, but one-in-four women experience bacterial vaginosis, in which a low level of lactobacilli is accompanied by an overgrowth of diverse anaerobic bacteria. This condition has been associated with many health complications, including risks to reproductive and sexual…
  • Virulence Factors of Candida spp. and Host Immune Response Important in the Pathogenesis of Vulvovaginal Candidiasis. [Review]
    Int J Mol Sci. 2022 May 24; 23(11)Czechowicz P, Nowicka J, Gościniak G
  • Vulvovaginal candidiasis (VVC) is one of the most common types of vaginal infections in women around the world and is often underestimated by both patients and doctors. Research on the pathogenesis of fungal vaginal infections over the last 20 years has resulted in a closer understanding of the virulence factors involved in Candida epithelial invasion and their mechanisms of action. Recently, att…
  • A Deep Look at the Vaginal Environment During Pregnancy and Puerperium. [Journal Article]
    Front Cell Infect Microbiol. 2022; 12:838405.Severgnini M, Morselli S, … Marangoni A
  • A deep comprehension of the vaginal ecosystem may hold promise for unraveling the pathophysiology of pregnancy and may provide novel biomarkers to identify subjects at risk of maternal-fetal complications. In this prospective study, we assessed the characteristics of the vaginal environment in a cohort of pregnant women throughout their different gestational ages and puerperium. Both the vaginal …
  • Vaginosis: Advances in new therapeutic development and microbiome restoration. [Review]
    Microb Pathog. 2022 Jul; 168:105606.Mohankumar B, Shandil RK, … Krishnan UM
  • Vaginosis is a condition experienced by most women at least once in their lifetime. This condition arises due to the imbalance in the microbiome of the vaginal ecosystem. Most of the pathogens of this disease are organisms which are commonly found in a normal healthy vagina. The vaginal microbiome is important as they act as a primary defence against secondary infections and Sexually transmitted …
  • Correlates of bacterial vaginosis among women from North India. [Journal Article]
    Int J STD AIDS. 2022 Jun; 33(7):666-671.Challa A, Kachhawa G, … Gupta S
  • Background: Bacterial vaginosis (BV) is the most prevalent cause of abnormal vaginal discharge among pre-menopausal women and associated with adversities of sexual and reproductive health. The present study aimed to identify potential epidemiological and behavioural risk factors and clinical predictors of BV among women in Delhi, India. Methods: A cross-sectional study was conducted to assess 283…
  • Determining Susceptibility in Candida Vaginal Isolates. [Journal Article]
    Antimicrob Agents Chemother. 2022 Jun 21; 66(6):e0236621.Sobel JD, Akins R
  • Antifungal drug susceptibility tests (AST) for Candida albicans are increasingly demanded for women with refractory or recurrent Candida vaginitis due to fluconazole resistance. Given reduced activity of azole drugs at pH levels found in women with Candida vaginitis, it is proposed that AST be performed at pH 4.5, since testing at only the recommended pH 7.0 is likely to miss a significant number…
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