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(Viral Hepatitis)
117,053 results
  • Oncogenic Viral Protein Interactions with p53 Family Proteins. [Journal Article]
    Klin Onkol 2019; 32(Supplementum 3):72-77Brychtová V, Hrabal V, Vojtěšek B
  • Cellular transformation induced by oncogenic viruses is a complex process including viral molecules, host cells and environmental factors. Viruses alone are unable to reproduce and thus they need a host to use their signalling, proteosynthetic and metabolic pathways. One target host molecule is the p53 tumour suppressor. Viral proteins functionally inactivate p53 and deregulate the expression of …
  • The Evolutionary Arms Race between Virus and NK Cells: Diversity Enables Population-Level Virus Control. [Review]
    Viruses 2019; 11(10)Savoy SKA, Boudreau JE
  • Viruses and natural killer (NK) cells have a long co-evolutionary history, evidenced by patterns of specific NK gene frequencies in those susceptible or resistant to infections. The killer immunoglobulin-like receptors (KIR) and their human leukocyte antigen (HLA) ligands together form the most polymorphic receptor-ligand partnership in the human genome and govern the process of NK cell education…
  • Foodborne viral outbreaks associated with frozen produce. [Journal Article]
    Epidemiol Infect 2019; 147:e291Nasheri N, Vester A, Petronella N
  • Over the past decade, frozen fruits have been a major vehicle of foodborne illnesses mainly attributed to norovirus (NoV) and hepatitis A virus (HAV) infections. Fresh produce may acquire viral contamination by direct contact with contaminated surface, water or hands, and is then frozen without undergoing proper decontamination. Due to their structural integrity, foodborne viruses are able to wit…
  • The activity prediction of indole inhibitors against HCV NS5B polymerase. [Journal Article]
    Chem Biol Drug Des 2019Muhire J, Zhai HL, … Mi JY
  • Nonstructural viral protein 5B (NS5B) is a viral-protein in Hepatitis C Virus. Although various inhibitors against NS5B have been found, the activity prediction of similar untested inhibitors is still highly desirable. In this respect, the Tchebichef moments (TMs) calculated from the images of molecular structures were regarded as the independent variables while the inhibitory activity (pIC50) wa…
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