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22,683 results
  • Detection of gene mutations in gastric cancer tissues using a commercial sequencing panel. [Journal Article]
    Mol Clin Oncol 2019; 11(5):455-460Ito T, Matoba R, … Sato K
  • Predicting malignancy is important for adequate adjuvant therapy in patients with cancer. Due to cancer being a genetic disease, the detection of gene mutations could be helpful in predicting the prognosis and efficacy of drugs. Gastric cancer is the fifth most common cancer and is the third leading cause of cancer associated mortality worldwide. Mutations in genes may correlate with clinical inf…
  • The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. [Journal Article]
    Nature 2019Hoshino A, Wang WJ, … Arany Z
  • Mitochondrial homeostasis vitally depends on mitophagy, the programmed degradation of mitochondria. The roster of proteins known to participate in mitophagy remains small. We devised here a multidimensional CRISPR/Cas9 genetic screen, using multiple mitophagy reporter systems and pro-mitophagy triggers, and uncover numerous new components of Parkin-dependent mitophagy1. Unexpectedly, we identify …
  • Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides. [Journal Article]
    Nucleosides Nucleotides Nucleic Acids 2019; :1-10Yamamoto T, Sawamura M, … Harada-Shiba M
  • The asialoglycoprotein receptor (ASGPr) and N-acetylgalactosamine (GalNAc) is one of the most reliable receptor-ligand combinations for delivering antisense oligonucleotides (ASOs) to the liver. Here, we show that a modular GalNAc conjugation strategy allows us to reinforce the activity of the parent, naked 2',4'-BNA/LNA gapmer targeting apolipoprotein B. The conjugation partly reduced a possible…
  • Expression and function of dopamine in odontoblasts. [Journal Article]
    J Cell Physiol 2019Fujino S, Hamano S, … Maeda H
  • Dopamine (DA) is produced from tyrosine by tyrosine hydroxylase (TH). A recent study has reported that DA promotes the mineralization of murine preosteoblasts. However, the role of DA in odontoblasts has not been examined. Therefore, in this investigation, we researched the expression of TH and DA in odontoblasts and the effects of DA on the differentiation of preodontoblasts (KN-3 cells). Immuno…
  • The variable heartbeat of Japanese moles (Mogera spp.). [Journal Article]
    J Comp Physiol B 2019Matsuo T, Kashimura A, Wada N
  • This report demonstrates the variable cardiac rhythm in two species of subterranean mole, the large Japanese mole (Mogera wogura) and the lesser Japanese mole (Mogera imaizumii). The phenomenon was revealed using X-ray videos of M. wogura and investigated in detail using electrocardiogram (ECG) traces recorded with implanted electrodes in this species and M. imaizumii. Cessation of heartbeat and …
  • A Japanese history of the Human Genome Project. [Journal Article]
    Proc Jpn Acad Ser B Phys Biol Sci 2019; 95(8):441-458Sakaki Y
  • The Human Genome Project (HGP) is one of the most important international achievements in life sciences, to which Japanese scientists made remarkable contributions. In the early 1980s, Akiyoshi Wada pioneered the first project for the automation of DNA sequencing technology. Ken-ichi Matsubara exhibited exceptional leadership to launch the comprehensive human genome program in Japan. Hideki Kamba…
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