- A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema. [Review]
- IJInt J Dermatol 2018 Feb 16
- Necrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome. It presents with annular eruptions of migrating erythematous papules and pla...
Necrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome. It presents with annular eruptions of migrating erythematous papules and plaques with superficial epidermal necrosis, central flaccid bullae, and crusted erosions located primarily in the intertriginous areas. Treatment with the long-acting somatostatin analog Octreotide is a potential therapy to help ameliorate skin symptoms. We present a case of a patient with a 1-year history of a pancreatic glucagonoma that developed an ulcerated, plaque-like, weeping rash over multiple areas of their body despite current treatment with Octreotide and stable pancreatic tumor staging. The patient had a similar rash when initially diagnosed with a glucagonoma, and it quickly improved after Octreotide treatment. Clinical examination and biopsy were consistent with necrolytic migratory erythema due to an underlying glucagonoma. This rare case adds to our understanding of the clinical presentation of NME, as well as highlights the relapsing and remitting course, even if the underlying pancreatic tumor is stable and the patient is undergoing treatment.
- Concurrent Painless Weeping Nodule and Targetoid Lesion on the Hand. [Journal Article]
- AFAm Fam Physician 2017 Dec 01; 96(11):739-741
- Exploring DNA variant segregation types in pooled genome sequencing enables effective mapping of weeping trait in Malus. [Journal Article]
- JEJ Exp Bot 2018 Jan 18
- To unlock the power of next generation sequencing-based bulked segregant analysis in allele discovery in out-crossing woody species, and to understand the genetic control of weeping trait, an F1 popu...
To unlock the power of next generation sequencing-based bulked segregant analysis in allele discovery in out-crossing woody species, and to understand the genetic control of weeping trait, an F1 population from cross 'Cheal's Weeping' × 'Evereste' was used to create two genomic DNA pools 'weeping (17 progeny)' and 'standard (16 progeny)'. Illumina pair-end (2x151bp) sequencing of the pools to a 27.1x (weeping) and a 30.4x (standard) genome (742.3Mb) coverage allowed detection of 84,562 DNA variants specific to 'weeping', 92,148 specific to 'standard' and 173,169 common to both pools. A detailed analysis of the DNA variant genotypes in the pools predicted three informative segregation types of variants: <lm x mm> (Type-I) in weeping pool specific variants, and <lm x ll> (Type-II) and <hk x hk> (Type-III) in variants common to both pools. Note: the first allele is assumed weeping linked and the allele in bold is a variant to the reference genome. Conducting variant allele frequency and density-based mappings revealed four genomic regions with a significant association with weeping: a major locus Weeping (W) on chromosome 13 and others on chromosomes 10 (W2), 16 (W3) and 5 (W4). The results from Type-I variants were noisier and less certain than those from Type-II and Type-III variants, demonstrating that although Type-I variants are often the first choice, Type-II and Type-III variants represent an important source of DNA variants that can be exploited for genetic mapping in out-crossing woody species. Confirmation of the mapping of W and W2, investigation into their genetic interactions, and identification of expressed genes in the W and W2 regions provided insight into the genetic control of weeping and its expressivity in Malus.
- [Specifics of some calcium salts in intravenous therapy of hypocalcemia and their further use]. [Journal Article]
- CSCeska Slov Farm 2017; 66(4):160-163
- Hypocalcemia is a serious condition which has a major impact on the transmission of nerve impulses, contraction and relaxation of muscles (including myocardial) and pathological secretion of some hor...
Hypocalcemia is a serious condition which has a major impact on the transmission of nerve impulses, contraction and relaxation of muscles (including myocardial) and pathological secretion of some hormones. The basic causal treatment is the parenteral administration of calcium, namely calcium gluconate, calcium chloride or calcium gluceptate. Parenteral formulations of these compounds must meet pharmacopoeial requirements, including the aluminum content limit. Each of these molecules has its specific properties that predict their clinical use. In addition to hypocalcemia, they are used to influence a variety of other conditions, such as fluoride or oxalic acid poisoning, decreased myocardial contractility caused by overdose of calcium intake blockers or beta blockers. They are also used as part of parenteral nutrition AIO or as an ancillary treatment for acute allergic conditions, itchy dermatitis, weeping and generalized eczema, continuous renal replacement therapy, seizure convulsion, laryngospasm, bronchospasm and altered mental status. The role of calcium replacement in septic patients remains unclear and requires further study. Although it may appear that calcium chloride infusion solutions provide greater and more highly ionized amounts of calcium, gluconate salts are preferred due to considerably less irritation of the vessel wall and better compatibility with other nutrients in parenteral nutrition.Key words: hypocalcemia calcium gluconate calcium chloride aluminum parenteral nutrition.
- Migration of a ventriculo-peritoneal shunt catheter into a back incision of a patient with previous spinal fusion. [Journal Article]
- CNChilds Nerv Syst 2018 Jan 02
- CONCLUSIONS: In abandoned VP shunts, migration into a non-sterile cavity dictates prompt removal, especially after symptoms of infection present. Additionally, careful monitoring for signs of peritonitis or other symptoms for a dedicated period of time is necessary. To the authors' best knowledge, this is the first case of an occult shunt migration through the patient's back that presented with a weeping abscess.
- Transcriptional and Hormonal Regulation of Weeping Trait in Salix matsudana. [Journal Article]
- GGenes (Basel) 2017 Nov 30; 8(12)
- Salix matsudana is a large and rapidly-growing tree, with erect or spreading branchlets (upright willow). However, S. matsudana var. pseudomatsudana is one of the varietas, with pendulous branchlets ...
Salix matsudana is a large and rapidly-growing tree, with erect or spreading branchlets (upright willow). However, S. matsudana var. pseudomatsudana is one of the varietas, with pendulous branchlets (weeping willow). It has high ornamental value for its graceful pendulous branches. In order to study the molecular basis for this weeping trait, leaves and stems collected at different developmental stages were analyzed using RNA-seq coupled with digital gene expression. Although weeping trees are used worldwide as landscape plants, little is known about the genes that control weeping. Our growth results indicated that branches in weeping willow developed and elongated throughout all developmental stages, but branches in upright willow grew rapidly in the initial stages and then grew slowly and began shoot branching in the middle stages. A total of 613 hormone-related genes were differentially expressed in willow development. Among these, genes associated with auxin and gibberellin (GA) were highly likely to be responsible for the weeping trait, and genes associated with auxin and ethylene probably play crucial roles in shoot elongation. The genes with differential expression patterns were used to construct a network that regulated stem development, and auxin-related genes were identified as hub genes in the network in the weeping willow. Our results suggest an important role of gibberellin and auxin in regulating the weeping trait in Salix matsudana. This is the first report on the molecular aspects of hormonal effects on weeping trait in willow using transcriptomics and helps in dissecting the molecular mechanisms by which the weeping trait is controlled.
- Content validation of behaviours and autonomic responses for the assessment of pain in critically ill adults with a brain injury. [Journal Article]
- ACAust Crit Care 2017 Nov 13
- CONCLUSIONS: Facial expressions, movements towards the pain site, and vocalisation of pain were the most relevant pain-related behaviours rated by critical care clinicians. The relevance of some behaviours (e.g., moaning and verbal complaints of pain) varied across LOCs, thereby calling forth adaptations of behavioural pain scales to allow for interpretation in the context of a patient's LOC and ability to express specific behaviours.
- Teaching Video NeuroImages: My weeping patient: Avoiding the pitfalls of a functional diagnosis. [Journal Article]
- NeurNeurology 2017 Oct 17; 89(16):e202
- LAZY Genes Mediate the Effects of Gravity on Auxin Gradients and Plant Architecture. [Journal Article]
- PPPlant Physiol 2017; 175(2):959-969
- A rice (Oryza sativa) mutant led to the discovery of a plant-specific LAZY1 protein that controls the orientation of shoots. Arabidopsis (Arabidopsis thaliana) possesses sixLAZYgenes having spatially...
A rice (Oryza sativa) mutant led to the discovery of a plant-specific LAZY1 protein that controls the orientation of shoots. Arabidopsis (Arabidopsis thaliana) possesses sixLAZYgenes having spatially distinct expression patterns. Branch angle phenotypes previously associated with singleLAZYgenes were here studied in roots and shoots of single and higher-orderatlazymutants. The results identify the major contributors to root and shoot branch angles and gravitropic behavior of seedling hypocotyls and primary roots.AtLAZY1is the principal determinant of inflorescence branch angle. The weeping inflorescence phenotype ofatlazy1,2,4mutants may be due at least in part to a reversal in the gravitropism mechanism.AtLAZY2andAtLAZY4determined lateral root branch angle. Lateral roots of theatlazy2,4double mutant emerged slightly upward, approximately 10° greater than perpendicular to the primary root axis, and they were agravitropic. Etiolated hypocotyls of the quadrupleatlazy1,2,3,4mutant were essentially agravitropic, but their phototropic response was robust. In light-grown seedlings, the root of theatlazy2,3,4mutant was also agravitropic but when adapted to dim red light it displayed a reversed gravitropic response. A reversed auxin gradient across the root visualized by a fluorescent signaling reporter explained the reversed, upward bending response. We propose that AtLAZY proteins control plant architecture by coupling gravity sensing to the formation of auxin gradients that override a LAZY-independent mechanism that creates an opposing gravity-induced auxin gradient.
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- Diffuse dermal angiomatosis mimicking inflammatory breast carcinoma. [Case Reports]
- BJBreast J 2017 Jul 26
- Diffuse dermal angiomatosis (DDA) is a rare pathologically distinct subtype of reactive angioendotheliomatosis. In the literature, few biopsy-proven cases involving breast skin have been reported. We...
Diffuse dermal angiomatosis (DDA) is a rare pathologically distinct subtype of reactive angioendotheliomatosis. In the literature, few biopsy-proven cases involving breast skin have been reported. We present a case of a 49-year-old female who presented with an indurated, erythematous, weeping, puckered and tender lesion with focal ulceration. Mammography demonstrated diffuse cutaneous and trabecular thickening concerning for inflammatory breast carcinoma. A punch biopsy demonstrated findings consistent with DDA. To our knowledge, this is the first reported case of DDA mimicking inflammatory carcinoma of the breast by clinical and radiologic examination.