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901 results
  • Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age. [Journal Article]
    Thorax 2019Grudzinska FS, Brodlie M, … Sapey E
  • "Science means constantly walking a tight rope" Heinrich Rohrer, physicist, 1933. Community-acquired pneumonia (CAP) is the leading cause of death from infectious disease worldwide and disproportionately affects older adults and children. In high-income countries, pneumonia is one of the most common reasons for hospitalisation and (when recurrent) is associated with a risk of developing chronic p…
  • Non-adherence to malaria prophylaxis: The influence of travel-related and psychosocial factors. [Journal Article]
    J Infect Public Health 2019Hoefnagel JGM, Massar K, Hautvast JLA
  • CONCLUSIONS: About one-third of the travellers in our study were non-compliant with malaria prophylaxis, especially young travellers and highly educated travellers. Fatigue during travel seems to lead to non-compliance. Further research should focus on addressing the psychosocial factors in pre-travel consultation, since these appear to be better predictors for intention to comply than travel-related variables.
  • Contributions of cardiovascular risk and smoking to chronic obstructive pulmonary disease (COPD)-related changes in brain structure and function. [Journal Article]
    Int J Chron Obstruct Pulmon Dis 2019; 14:1855-1866Spilling CA, Bajaj MK, … Dodd JW
  • CONCLUSIONS: COPD is associated with both structural (gray matter atrophy) and functional (worse cognitive function and mood) brain changes that cannot be explained by measures of cardiovascular risk, aortic stiffness, or smoking history alone. These results have important implications to guide the development of new interventions to prevent or delay progression of neuropsychiatric comorbidities in COPD. Relationships found between mood and microstructural abnormalities suggest that in COPD, anxiety, and depression may occur secondary to WM damage. This could be used to better understand disabling symptoms such as breathlessness, improve health status, and reduce hospital admissions.
  • How Do We Treat Pregnancy-Related Venous Thromboembolism? [Journal Article]
    Hamostaseologie 2019Linnemann B, Seelbach-Goebel B, … Hart C
  • Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality during pregnancy and the postpartum period. Due to a lack of adequate study data, therapeutic strategies for pregnancy-related VTE are deduced from observational studies and extrapolated from recommendations for nonpregnant patients. Because heparins do not cross the placenta, weight-adjusted therapeutic-dose low-mo…
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