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1,518 results
  • Identification of Major ADH Genes in Ethanol Metabolism of Pichia pastoris. [Journal Article]
    Yeast 2019Karaoğlan M, Erden-Karaoğlan F, … İnan M
  • The methylotrophic yeast Pichia pastoris (syn. Komagataella phaffii) is a successful host widely used in recombinant protein production. The widespread use of a methanol-regulated alcohol oxidase 1 (AOX1) promoter for recombinant protein production has directed studies particularly about methanol metabolism in this yeast. Although there is comprehensive knowledge about methanol metabolism, there …
  • Glyoxalase 1 expression is downregulated in preimplantation blastocysts of diabetic rabbits. [Journal Article]
    Reprod Domest Anim 2019; 54 Suppl 3:4-11Seeling T, Haucke E, … Navarrete Santos A
  • In a diabetic pregnancy, an altered maternal metabolism led to increased formation of reactive α-dicarbonyls such as glyoxal (GO) and methylglyoxal (MGO) in the reproductive organs and embryos. The enzyme glyoxalase (GLO) 1 detoxifies reactive α-dicarbonyls thus protecting cells against malfunction or modifications of proteins by advanced glycated end products (AGEs). The aim of this study was to…
  • Collagens and DNA methyltransferases in mare endometrosis. [Journal Article]
    Reprod Domest Anim 2019; 54 Suppl 3:46-52Alpoim-Moreira J, Fernandes C, … Ferreira-Dias G
  • Inflammation and fibroproliferative diseases may be modulated by epigenetic changes. Therefore, we suggest that epigenetic mechanisms could be involved in equine endometrosis pathogenesis. DNA methylation is one of the methods to evaluate epigenetics, through the transcription of methyltransferases (DNMT1, DNMT3A, DNMT3B). The correlation between DNMTs and collagen (COL) transcripts was assessed …
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