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Unbound Medicine.
(Zollinger Ellison syndrome)
3,579 results
  • De novo Gastrinoma: A Case Report. [Case Reports]
    GE Port J Gastroenterol. 2020 Apr; 27(3):192-196.Barbosa A, Gomes F, … Almeida J
  • Gastrinomas are neuroendocrine tumors characterized by gastrin overexpression - 80% are sporadic and 20% are associated with multiple endocrine neoplasia type 1. A 75-year-old male patient, surgically treated at the age of 50 years for gastrinoma, followed on an outpatient basis because of chronic non-bloody diarrhea, was admitted to our hospital because of abdominal pain, watery diarrhea, and no…
  • The Neuroendocrine Neoplasms of the Digestive Tract: Diagnosis, Treatment and Nutrition. [Review]
    Nutrients. 2020 May 15; 12(5)Pobłocki J, Jasińska A, … Szczuko M
  • Nuroendocrine neoplasms (NENs) are a group of rare neoplasms originating from dispersed neuroendocrine cells, mainly of the digestive and respiratory tract, showing characteristic histology and immunoprofile contributing to classification of NENs. Some NENs have the ability to produce biogenic amines and peptide hormones, which may be associated with clinical syndromes like, e.g., the carcinoid s…
  • Management of Other Gastric and Duodenal Neuroendocrine Tumors. [Review]
    Surg Oncol Clin N Am. 2020 Apr; 29(2):253-266.Laird AM, Libutti SK
  • Gastric and duodenal neuroendocrine tumors (NETs) are increasing in incidence as a result of increased detection and awareness of neuroendocrine tumors as distinct tumor types. The three types of gastric NETs and duodenal NETs have different etiologies and tumor-specific factors, such as grade, location, and hormone-production, and the clinical settings influence management. Options for treatment…
  • Proton pump inhibitors from clinical pharmacists point of view. [Journal Article]
    Cas Lek Cesk. 2019 Winter; 158(7-8):282-288.Pilková A
  • Proton pump inhibitors (PPIs) are very effective drugs in treatment and prevention of acid-related disorders. They are widely used in gastroesophageal reflux disease, gastroduodenal ulcers, Zollinger-Ellison syndrome or prevention and treatment of NSAIDs induced gastric lesions. They are also used in many other indications, although not always is their use appropriate. PPIs are generally well tol…
  • Proton Pump Inhibitor Use, Hypergastrinemia, and Gastric Carcinoids-What Is the Relationship? [Review]
    Int J Mol Sci. 2020 Jan 19; 21(2)McCarthy DM
  • Neuroendocrine tumors (NETs) throughout the body are the focus of much current interest. Most occur in the gastrointestinal tract and have shown a major increase in incidence over the past 30 years, roughly paralleling the world-wide increase in the use of proton pump inhibitor (PPI) drugs. The greatest rise has occurred in gastric carcinoids (g-NETs) arising from enterochromaffin-like (ECL) cell…
  • Atypical Thymic Carcinoid in a Patient with Zollinger-Ellison Syndrome. [Case Reports]
    Korean J Thorac Cardiovasc Surg. 2019 Dec; 52(6):420-424.Lee J, Hyun K, … Kim KS
  • Atypical thymic carcinoid is an extremely rare tumor with a poor prognosis. In addition to its known association with multiple endocrine neoplasia type 1, its hallmark characteristics include local invasion and early distant metastasis. In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome.
  • [Gastric neuroendocrine tumors]. [Journal Article]
    Khirurgiia (Mosk). 2019Alekberzade AV, Krylov NN, … Azari F
  • Gastrointestinal neuroendocrine tumors are rare neoplasms. Currently, incidence of gastric neuroendocrine tumors (gNETs) is being significantly increased. There are 3 groups of gNETs: types I, II and III. Each type has important features regarding clinical picture, prognosis and treatment strategy. Type I is the most common (70-80%) and associated with chronic atrophic gastritis including autoimm…
  • Diagnostic accuracy of selective arterial calcium injection test for localization of gastrinoma. [Journal Article]
    Endocr J. 2020 Mar 28; 67(3):305-315.Hayashi R, Minami I, … Yamada T
  • The appropriate localization of gastrinoma is still difficult. We aimed to evaluate the diagnostic accuracy of selective arterial calcium injection (SACI) for localization of gastrinomas including multiple lesions. This retrospective study included ten patients with surgically proven gastrinomas (gastrinoma group) and six patients without any findings suggesting Zollinger-Ellison syndrome (non-ga…
  • The Pancreatic Endocrine Tumors - Experience of First Surgical Clinic Iasi. [Journal Article]
    Chirurgia (Bucur). 2019 Sept-Oct; 114(5):639-649.Târcoveanu E, Lupascu C, … Bradea C
  • CONCLUSIONS: Knowledge of clinical signs of secreting tumors and exploring the patients are of crucial importance for management of PNETs. Immunohistochemistry is mandatory for confirming the diagnosis and assessing the proliferation and biological behavior of the tumor, thus facilitating the administration of specific therapy. Aggressive surgical treatment is indicated, even in advanced stages.
  • Occurrence of Acute Oesophageal Necrosis (Black Oesophagus) in a Single Tertiary Centre. [Journal Article]
    J Clin Med. 2019 09 24; 8(10)Orlando D, Carabotti M, … Annibale B
  • Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction. This observational study aimed to assess the occurrence, clinical characteristics and outcomes of AON in a consecutive endoscopic cohort in a single tertiary university cent…
  • Medical Genetics Summaries: Esomeprazole Therapy and CYP2C19 Genotype [BOOK]
    . National Center for Biotechnology Information (US): Bethesda (MD)Pratt VM, McLeod HL, … Malheiro AJDean LBOOK
  • Esomeprazole (brand name Nexium) is a proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD) and to reduce the risk of gastric ulcers associated with nonsteroidal anti-inflammatory drug NSAID use. Esomeprazole is also used in the treatment of hypersecretory conditions, such as Zollinger-Ellison syndrome, and in combination with antibiotics to eradicate Helicobacter pylor…
  • Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies. [Review]
    World J Gastroenterol. 2019 Aug 28; 25(32):4673-4681.Shao QQ, Zhao BB, … Wang WB
  • Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic disease. Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial. Based on a thorough literature review, we design a surgical algorithm for ZES and lis…
  • Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1. [Review]
    Best Pract Res Clin Endocrinol Metab. 2019 10; 33(5):101318.Albers MB, Manoharan J, Bartsch DK
  • About 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless …
  • Low-Value Proton Pump Inhibitor Prescriptions Among Older Adults at a Large Academic Health System. [Journal Article]
    J Am Geriatr Soc. 2019 12; 67(12):2600-2604.Mafi JN, May FP, … Sarkisian C
  • CONCLUSIONS: One in eight older adults were prescribed a PPI, and over one-third of prescriptions were potentially low-value. Most often, appropriate short-term prescriptions became potentially low value because they lacked long-term indications. With most potentially low-value prescribing concentrated among a small subset of PCPs, interventions targeting them and/or applying EHR-based automatic stopping rules may protect older adults from harm. J Am Geriatr Soc 67:2600-2604, 2019.
  • Zollinger Ellison Syndrome in a Patient with Multiple Endocrine Neoplasia Type 1: A Classic Presentation. [Case Reports]
    Case Rep Gastrointest Med. 2019; 2019:9605769.Shah I, Vyas N, Kadkhodayan KS
  • Zollinger Ellison Syndrome (ZES) is characterized by a wide spectrum of conditions including severe gastroesophageal reflux disease, peptic ulcer disease, watery diarrhea, and weight loss. We present a case of a 60-year-old woman being evaluated for severe dyspepsia, vomiting, and chronic diarrhea, who was diagnosed to have ZES associated with a pancreatic neuroendocrine tumor, in the setting of …
  • StatPearls: Zollinger Ellison Syndrome [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Cho Min S. MS McLaren Greater Lansing Kasi Anup A University of Kansas BOOK
  • Zollinger-Ellison syndrome (ZES) is a group of symptoms comprised of severe peptic ulcer disease, gastroesophageal reflux disease (GERD), and chronic diarrhea caused by a gastrin-secreting tumor of the duodenum or pancreas (gastrinoma triangle) that results in increased stimulation of acid-secreting cells of the stomach.[1][2] Gastrinoma is a functional neuroendocrine tumor that secretes gastric …
  • Gastrinoma of Cystic Duct: A Rare Association With Multiple Endocrine Neoplasia Type 1. [Case Reports]
    J Clin Med Res. 2018 Nov; 10(11):843-847.Moraes AB, Treistman N, … Vieira Neto L
  • Neuroendocrine tumors (NETs) of cystic duct are extremely rare, accounting for less than 2% of NET cases. The association of biliary tree NET and multiple endocrine neoplasm type 1 (MEN1) are even more rare. In this report, we described a case of a 65-year-old woman who was referred to our neuroendocrine outpatient clinic to investigate MEN1 after an incidental diagnosis of gastrinoma. Her medica…
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