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1,332 results
  • Structural Analysis of the Histamine H1 Receptor. [Journal Article]
  • HEHandb Exp Pharmacol 2016 Nov 09
  • Shiroishi M, Kobayashi T
  • The crystal structure of the human histamine H1 receptor (H1R) has been determined in complex with its inverse agonist doxepin, a first-generation antihistamine. The crystal structure showed that dox...
  • Review of Safety and Efficacy of Sleep Medicines in Older Adults. [Review]
  • CTClin Ther 2016; 38(11):2340-2372
  • Schroeck JL, Ford J, … Mergenhagen KA
  • CONCLUSIONS: An ideal treatment for insomnia should help to improve sleep latency and sleep duration with limited awakenings and be without significant adverse effects such as daytime somnolence or decreased alertness. Cognitive behavioral therapy should always be first line treatment. Clinical inertia regarding previous prominent use of benzodiazepines and non-BzRAs will be a significant challenge for patients accustomed to their issuance. The future direction of insomnia treatment should have an emphasis on nonpharmacologic interventions, treating comorbid conditions, and focusing therapy on using benzodiazepines and non-BzRAs as last resorts.
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