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11,837 results
  • Sexual dimorphism in obesity-associated endothelial ENaC activity and stiffening in mice. [Journal Article]
    Endocrinology 2019Padilla J, Woodford ML, … Manrique-Acevedo C
  • Obesity and insulin resistance stiffen the vasculature with females appearing to be more adversely affected. As augmented arterial stiffness is an independent predictor of cardiovascular disease (CVD), the increased predisposition of obese and insulin-resistant women to arterial stiffening may explain their heightened risk for CVD. However, the cellular mechanisms by which females are more vulner…
  • Driving factors in amiloride recognition of HIV RNA targets. [Journal Article]
    Org Biomol Chem 2019Patwardhan NN, Cai Z, … Hargrove AE
  • Noncoding RNAs are increasingly promising drug targets yet ligand design is hindered by a paucity of methods that reveal driving factors in selective small molecule : RNA interactions, particularly given the difficulties of high-resolution structural characterization. HIV RNAs are excellent model systems for method development given their targeting history, known structure-function relationships,…
  • A Systematic Review and Meta-Analysis of the Pressure-Induced Vasodilation Phenomenon and Its Role in the Pathophysiology of Ulcers. [Journal Article]
    Plast Reconstr Surg 2019; 144(4):669e-681eZwanenburg PR, Backer SFM, … Boermeester MA
  • CONCLUSIONS: This systematic review and meta-analysis indicates that healthy humans have the capacity to increase local perfusion in response to mechanical stress resulting from tissue compression. Because pressure-induced vasodilation is mediated by sensory nerves, pressure-induced vasodilation emphasizes the importance of sensory innervation for durable tissue integrity. Pressure-induced vasodilation impairment seems to provide a complementary explanation for the susceptibility of neuropathic tissues to pressure-induced lesions.
  • Liddle's syndrome mechanisms, diagnosis and management. [Journal Article]
    Integr Blood Press Control 2019; 12:13-22Enslow BT, Stockand JD, Berman JM
  • Liddle's syndrome is a genetic disorder characterized by hypertension with hypokalemic metabolic alkalosis, hyporeninemia and suppressed aldosterone secretion that often appears early in life. It results from inappropriately elevated sodium reabsorption in the distal nephron. Liddle's syndrome is caused by mutations to subunits of the Epithelial Sodium Channel (ENaC). Among other mechanisms, such…
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