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2,703 results
  • In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity. [Journal Article]
    J Immunotoxicol 2019; 16(1):125-132Ito S, Ikuno T, … Kubo C
  • Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA). If the immunogenicity of a new candidate can be understood in the nonclinical phase, clinical studies will be safer and the success rate of develo…
  • Mirror Distal Anterior Cerebral Artery Aneurysms in a Patient with Subarachnoid Hemorrhage. [Journal Article]
    World Neurosurg 2019; 129:101-104Schwartz C, Jahromi BR, … Niemelä M
  • CONCLUSIONS: Rapid identification of the rupture site in patients with subarachnoid hemorrhage and multiple aneurysms is crucial for initiating optimal treatment. In patients with mirror aneurysms in close proximity to each other, this is not easily accomplished, complicating treatment decisions. Although clipping has been the standard for DACAA occlusion, coiling should be taken into consideration as a viable alternative.
  • Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: A narrative review. [Review]
    Rev Port Cardiol 2019; 38(4):289-297Caldeira D, Pereira H
  • This article reviews the major pharmacologic features of, and clinical evidence on, adjuvant medical therapy in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. These drugs include oral antiplatelets (aspirin and P2Y12 inhibitors such as clopidogrel, prasugrel and ticagrelor), intravenous antiplatelet agents (the P2Y12 inhibitor can…
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