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2,722 results
  • Neuroform Atlas stent-assisted coiling of ruptured intracranial aneurysms: A multicenter study. [Journal Article]
    J Neuroradiol. 2020 Mar 20 [Online ahead of print]Russo R, Bradac GB, … Bergui M
  • CONCLUSIONS: Stent assisted coiling of ruptured intracranial aneurysms is a feasible option when simple coiling is not possible. Optimal medical treatment is still controversial because balance between hemorrhagic and ischemic risks is difficult to evaluate. In our series, heparin bolus had no effect on subsequent stent thrombosis. In all cases peri-operative stent thrombosis was successfully managed using bail-out intravenous antiGP2b3a, which did not increase post-procedural hemorrhage rates. A non-significant trend towards increased complications rate was noticed in patients treated with single antiplatelet therapy versus double antiplatelet therapy.
  • StatPearls: Glycoprotein IIb/IIIa Inhibitors [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Tummala Ramyashree R Mount Sinai Beth Israel Rai Manoj P. MP Asante Rogue Regional Medical Center BOOK
  • Platelets are responsible for the formation of thrombus after endothelial injury, which is vital in maintaining normal hemostasis. Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors prevent platelet aggregation by blocking glycoprotein IIb/IIIa receptors; thus they found application in the management of coronary artery disease (CAD). The available GP IIb/IIIa inhibitors include abciximab, tirofiban, …
  • A Novel αIIbβ3 Antagonist from Snake Venom Prevents Thrombosis without Causing Bleeding. [Journal Article]
    Toxins (Basel). 2019 12 21; 12(1)Kuo YJ, Chung CH, … Huang TF
  • Life-threatening thrombocytopenia and bleeding, common side effects of clinically available αIIbβ3 antagonists, are associated with the induction of ligand-induced integrin conformational changes and exposure of ligand-induced binding sites (LIBSs). To address this issue, we examined intrinsic mechanisms and structure-activity relationships of purified disintegrins, from Protobothrops flavoviridi…
  • Life after abciximab; what's next for intracoronary thrombus? [Letter]
    J Thromb Thrombolysis. 2020 Jan; 49(1):138-140.McGhie D, Amos D, … Lowe HC
  • A case is described in which the short-acting glycoprotein IIb/IIIa receptor antagonist tirofiban was used in combination with heparin, aspirin and prasugrel to successfully treat extensive intracoronary thrombus in a delayed presentation STEMI, illustrating the utility of this approach.
  • In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity. [Journal Article]
    J Immunotoxicol. 2019 12; 16(1):125-132.Ito S, Ikuno T, … Kubo C
  • Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences from human origin, which may cause higher immunogenicity to induce anti-drug antibodies (ADA). If the immunogenicity of a new candidate can be understood in the nonclinical phase, clinical studies will be safer and the success rate of develo…
  • Mirror Distal Anterior Cerebral Artery Aneurysms in a Patient with Subarachnoid Hemorrhage. [Case Reports]
    World Neurosurg. 2019 Sep; 129:101-104.Schwartz C, Jahromi BR, … Niemelä M
  • CONCLUSIONS: Rapid identification of the rupture site in patients with subarachnoid hemorrhage and multiple aneurysms is crucial for initiating optimal treatment. In patients with mirror aneurysms in close proximity to each other, this is not easily accomplished, complicating treatment decisions. Although clipping has been the standard for DACAA occlusion, coiling should be taken into consideration as a viable alternative.
  • Adjuvant antithrombotic therapy in ST-elevation myocardial infarction: A narrative review. [Review]
    Rev Port Cardiol. 2019 04; 38(4):289-297.Caldeira D, Pereira H
  • This article reviews the major pharmacologic features of, and clinical evidence on, adjuvant medical therapy in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention. These drugs include oral antiplatelets (aspirin and P2Y12 inhibitors such as clopidogrel, prasugrel and ticagrelor), intravenous antiplatelet agents (the P2Y12 inhibitor can…
  • Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting. [Review]
    J Hematol Oncol. 2019 03 07; 12(1):26.Huang J, Li X, … Jin J
  • Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it plays a central role in platelet functions, hemostasis, and arterial thrombosis. Integrin αIIbβ3 also participates in cancer progression, such as tumor cell pr…
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