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(abiraterone)
1,967 results
  • Abiraterone in "High-" and "Low-risk" Metastatic Hormone-sensitive Prostate Cancer. [Journal Article]
    Eur Urol 2019Hoyle AP, Ali A, … STAMPEDE Investigators
  • CONCLUSIONS: A total of 901 M1 STAMPEDE patients were evaluated after exclusions. Of the patients, 428 (48%) were identified as having a low risk and 473 (52%) a high risk. Patients receiving ADT + AAP had significantly improved OS (low-risk hazard ratio [HR]: 0.66, 95% confidence interval or CI [0.44-0.98]) and FFS (low-risk HR: 0.24, 95% CI [0.17-0.33]) compared with ADT alone. Heterogeneity of effect was not seen between low- and high-risk groups for OS or FFS. For OS benefit in low risk, the number needed to treat was four times greater than that for high risk. However, this was not observed for the other measured endpoints.Men with mHNPC gain treatment benefit from ADT + AAP irrespective of risk stratification for "risk" or "volume".
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