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367 results
  • Drugs and Lactation Database (LactMed): IncobotulinumtoxinA [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • No data exist on the medical use of incobotulinumtoxinA during breastfeeding. However, one infant was safely breastfed during maternal botulism and no botulinum toxin was detectable in the mother's milk or infant. Since the doses used medically are far lower than those that cause botulism, amounts ingested by the infant, if any, are expected to be small and not cause any adverse effects in breast…
  • A treatment protocol for botulinum toxin injections in the treatment of pachyonychia congenita-associated keratoderma. [Journal Article]
    Br J Dermatol 2019Koren A, Sprecher E, … Artzi O
  • CONCLUSIONS: Btx treatment of PC-associated keratoderma following an optimized protocol leads to a major change in patients' quality of life. What's already known about this topic? Plantar pain is considered by patients to be the most severe and debilitating manifestation of pachyonychia congenita (PC). Over the past few years, a number of reports have shown that plantar injections of botulinum toxin (Btx) reduce or even eliminate pain, blistering and callosities in patients with PC. However, the injection technique, doses of Btx and methods of anaesthesia varied between reports and patients. What does this study add? Here we report our 4-year experience in providing 30 treatments to five patients following an optimized protocol. Btx was found to provide a quantifiable improvement in all patients treated. What is the translational message? Btx treatment of PC-associated keratoderma using a structured approach, which includes the use of a sufficient dose of Btx (200-400 U of onabotulinumtoxinA or 500-1000 U of abobotulinumtoxinA), and regular intervals between treatment sessions (of < 100 days), leads to a major change in patients' quality of life.
  • Topical skin therapies in subjects undergoing full facial rejuvenation. [Journal Article]
    J Cosmet Dermatol 2019; 18(3):798-805Dayan SH, Bacos JT, … Kalbag A
  • CONCLUSIONS: The cosmeceutical therapies used in this study in combination with abobotulinumtoxinA and hyaluronic acid filler improved subjects' skin quality, self-esteem, and projected first impressions. Larger studies are needed to determine the most efficacious combination of topical skin therapies with facial rejuvenation therapy.
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