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3,627 results
  • Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges. [Review]
    Eur J Med Chem. 2023 Jan 17; 249:115119.Mushtaq A, Azam U, … Naseer MM
  • Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st century. It is a well-recognized multifactorial health problem contributes significantly to high mortality rates by causing serious health complications mainly related to cardiovascular diseases, kidney damage and neuropathy. The inhibition of α-glucosidase (enzyme that catalyses starch hydrolysis in the i…
  • Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria. [Journal Article]
    ACS Chem Biol. 2023 Jan 17 [Online ahead of print]Tanoeyadi S, Tsunoda T, … Mahmud T
  • Acarbose is a well-known microbial specialized metabolite used clinically to treat type 2 diabetes. This natural pseudo-oligosaccharide (PsOS) shows potent inhibitory activity toward various glycosyl hydrolases, including α-glucosidases and α-amylases. While acarbose and other PsOSs are produced by many different bacteria, their ecological or biological role in microbial communities is still an o…
  • Exogenous c-di-GMP inhibited the biofilm formation of Vibrio splendidus. [Journal Article]
    Microb Pathog. 2023 Jan 12; 175:105981.Yang Y, Li W, … Zhang W
  • Vibrio splendidus, a gram-negative bacterium that is ubiquitously present in marine environments, has been increasingly deemed an important opportunistic pathogen of marine animals. In this study, the biofilm formation of V. splendidus was quantitatively determined and morphologically characterized. Three stages of biofilm formation, including adhesion, aggregation and maturation were observed in…
  • Anti-ageing effects of FDA-approved medicines: a focused review. [Review]
    J Basic Clin Physiol Pharmacol. 2023 Jan 13 [Online ahead of print]Thanapairoje K, Junsiritrakhoon S, … Supharattanasitthi W
  • Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found th…
  • New polychlorinated bibenzyls from Rhododendron minutiflorum. [Journal Article]
    Nat Prod Bioprospect. 2023 Jan 09; 13(1):2.Zhu YL, Deng L, … Liao HB
  • Five new polychlorinated bibenzyls (1-5) along with 3 known compounds (6-8) were isolated from the stems and leaves of Rhododendron minutiflorum. The chemical structures of all the isolates were determined by spectroscopic methods, and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses. Compounds 1-5 were halogenated compounds which bear three to five chlorine at…
  • Dual Regulation of Sulfonated Lignin to Prevent and Treat Type 2 Diabetes Mellitus. [Journal Article]
    Biomacromolecules. 2023 Jan 06 [Online ahead of print]Qi S, Jiang B, … Jin Y
  • With the rapid increase of diabetes cases in the world, there is an increasing demand for slowing down and managing diabetes and its effects. It is considered that a viable prophylactic treatment for type 2 diabetes mellitus (T2DM) is to reduce carbohydrate digestibility by controlling the activities of α-amylase and α-glucosidase to control postprandial hyperglycemia and promote the growth of in…
  • Taxotrophises A and B, two new polyphenols from the stems of Taxotrophis ilicifolius. [Journal Article]
    Nat Prod Res. 2023 Jan 06 [Online ahead of print]Do TNV, Nguyen HX, … Nguyen MTT
  • From the EtOAc extract of the wood of the stems of Taxotrophis ilicifolius (Moraceae), two new secondary metabolites, named taxotrophises A (1) and B (2), were isolated, together with five known compounds (3-7). Their chemical structures have been elucidated by extensive NMR spectroscopic analysis. All isolated compounds have been evaluated for α-glucosidase inhibitory activity. In the present wo…
  • Phenolic and bisamide derivatives from Aglaia odorata and their biological activities. [Journal Article]
    Nat Prod Res. 2022 Dec 29 [Online ahead of print]Yang X, Yu Y, … Yi P
  • Three new compounds (1-3), including two bisamide derivatives (1 and 2) and a lignin (3), along with 15 known compounds were isolated from Aglaia odorata. Compound 2 was a pair of enantiomers and successfully resolved into the anticipated enantiomers. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism (ECD) calculations, and X-ray crystallography. …
  • Nesidioblastosis: an uncommon complication seen post Roux-en-Y gastric bypass. [Journal Article]
    Endocrinol Diabetes Metab Case Rep. 2022 Dec 01; 2022Kim K, Greenspan JL, … Ennis E
  • Adult-onset nesidioblastosis is a rare complication of Roux-en-Y gastric bypass surgery and may occur months to years after the initial surgical procedure. It is manifested by a hyperinsulinemic, hypoglycemic state. The annual incidence of adult-onset hyperinsulinemic hypoglycemia is believed to be less than 0.1 in 1 000 000 with a mean age of onset of 47 years (1). Here, we describe a patient wh…
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