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45,275 results
  • The Pangenome: Diversity, Dynamics and Evolution of Genomes: Pangenomes and Selection: The Public Goods Hypothesis [BOOK]
    . Springer: Cham (CH)Tettelin H, Medini DMcInerney JO, Whelan FJ, … O’Connell MJBOOK
  • The evolution and structure of prokaryotic genomes are largely shaped by horizontal gene transfer. This process is so prevalent that DNA can be seen as a public good—a resource that is shared across individuals, populations, and species. The consequence is a network of DNA sharing across prokaryotic life, whose extent is becoming apparent with increased availability of genomic data. Within proka…
  • The Pangenome: Diversity, Dynamics and Evolution of Genomes: Bacterial Microevolution and the Pangenome [BOOK]
    . Springer: Cham (CH)Tettelin H, Medini DLassalle F, Didelot XBOOK
  • The comparison of multiple genome sequences sampled from a bacterial population reveals considerable diversity in both the core and the accessory parts of the pangenome. This diversity can be analysed in terms of microevolutionary events that took place since the genomes shared a common ancestor, especially deletion, duplication, and recombination. We review the basic modelling ingredients used i…
  • Insights into the structure and function of Est3 from the Hansenula polymorpha telomerase. [Journal Article]
    Sci Rep. 2020 Jul 06; 10(1):11109.Shepelev NM, Mariasina SS, … Polshakov VI
  • Telomerase is a ribonucleoprotein enzyme, which maintains genome integrity in eukaryotes and ensures continuous cellular proliferation. Telomerase holoenzyme from the thermotolerant yeast Hansenula polymorpha, in addition to the catalytic subunit (TERT) and telomerase RNA (TER), contains accessory proteins Est1 and Est3, which are essential for in vivo telomerase function. Here we report the high…
  • Identification of the Vo domain of V-ATPase in Bombyx mori silkworm. [Journal Article]
    Int J Biol Macromol. 2020 Jul 03 [Online ahead of print]Xie E, Guo H, … Xia Q
  • Vacuolar H+-ATPase (V-ATPase) is very important for eukaryotes and consists of a conserved V1 domain and slightly variable Vo domain. However, the Vo domain has not been systematically identified in the silkworm Bombyx mori. In this study, 11 Vo domain subunit members were identified throughout the genome of B. mori, including four isoforms of subunit a (BmVoa1-4), two isoforms of subunit e (BmVo…
  • Ebstein Anomaly in the Adult Patient. [Review]
    Cardiol Clin. 2020 Aug; 38(3):353-363.Fuchs MM, Connolly HM
  • Ebstein anomaly is a congenital malformation involving primarily the tricuspid valve, with failure of delamination from the underlying myocardium and right ventricular myopathy. Echocardiography is diagnostic in most patients and demonstrates apical displacement of the septal leaflet and variable tethering of leaflet tissue to the right ventricular myocardium. Operative intervention is considered…
  • The Axial Alignment of Titin on the Muscle Thick Filament Supports its Role as a Molecular Ruler. [Journal Article]
    J Mol Biol. 2020 Jun 30 [Online ahead of print]Bennett P, Rees M, Gautel M
  • The giant protein titin is expressed in vertebrate striated muscle where it spans half a sarcomere from the Z-disc to the M-band and is essential for muscle organisation, activity and health. The C-terminal portion of titin is closely associated with the thick, myosin-containing filament and exhibits a complex pattern of immunoglobulin and fibronectin domains. This pattern reflects features of th…
  • Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr. [Review]
    Biochem Pharmacol. 2020 Jun 30 [Online ahead of print]Wallet C, Rohr O, Schwartz C
  • Back in 1989 some studies have shown that the viral protein Vpr was dispensable for HIV-1 replication in vitro. From then the concept of accessory or auxiliary protein for Vpr has emerged and it is still used to date. However, Vpr soon appeared to be very important for in vivo virus spread and pathogenesis. Vpr has been involved in many biological functions including regulation of reverse transcr…
  • Inferior Hepatic Fissures: Anatomic Variants in Trinidad and Tobago. [Journal Article]
    Cureus. 2020 May 30; 12(5):e8369.Cawich SO, Gardner MT, … Naraynsingh V
  • Classic descriptions of the visceral surface of the human liver only define three fissures: transverse, sagittal and umbilical fissures. Any additional fissures that are present on the visceral surface of the liver are considered variant inferior hepatic fissures (IHFs). This study was carried out to document the prevalence of IHFs in the Eastern Caribbean. Knowledge of these variants is importan…
  • Uncommon Causes of Nerve Compression in the Distal Forearm. [Case Reports]
    Reumatol Clin. 2020 Jun 29 [Online ahead of print]Azevedo S, Guimarães F, … Teixeira F
  • CONCLUSIONS: The reported cases of accessory muscles or lipomas described in the literature as causes of median nerve compression clinic are mainly described only after the surgical decompression of the carpal tunnel, due to the maintenance of residual symptoms.Careful examination with an ultrasound evaluation prior to surgery may help to identify these cases and help planning surgical treatment.
  • Os Styloideum Resection Complicated by Severe Contact Dermatitis to 2-Octyl Cyanoacrylate: A Case Study. [Journal Article]
    Wound Manag Prev. 2020 Jul; 66(7):33-38.Googe B, May B, Cushing C
  • CONCLUSIONS: This case demonstrates 2 uncommon occurrences: a rare hand mass and severe contact dermatitis to 2-octyl cyanoacrylate with resultant tissue necrosis. Mass resection is commonly reserved for symptomatic os styloideum. Caution should be used when applying 2-octyl cyanoacrylate under a splint. Removal of glue and steroids provides effective treatment for severe contact dermatitis, but full-thickness injuries may require debridement and secondary closure.
  • Case Report: Familial Hypocalciuric Hypercalcaemia and Hashimoto's Thyroiditis. [Case Reports]
    Front Surg. 2020; 7:30.Mobarak S, Tarazi M, … Forgacs B
  • Introduction: Hypercalcaemia can be caused by many disorders. Primary hyperparathyroidism is the leading cause with parathyroidectomy being the definitive management. Familial hypocalciuric hypercalcaemia is a rarer cause in which resection of the parathyroid tissue does not result in normalized serum calcium. Case presentation: We report the unusual case of a 53-year-old lady who presented with …
  • Making and breaking leupeptin protease inhibitors in pathogenic gammaproteobacteria. [Journal Article]
    Angew Chem Int Ed Engl. 2020 Jul 01 [Online ahead of print]Li JH, Oh J, … Crawford J
  • Leupeptin is a bacterial small molecule that is used worldwide as a protease inhibitor. However, its biosynthesis and genetic distribution remain unknown. Here, we identified a family of leupeptins in gammaproteobacterial pathogens, including Photorhabdus, Xenorhabdus, and Klebsiella species, amongst others. Through genetic, metabolomic, and heterologous expression analyses, we established their …
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