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343,384 results
  • FSP1 is a glutathione-independent ferroptosis suppressor. [Journal Article]
    Nature 2019Doll S, Freitas FP, … Conrad M
  • Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been believed to be restrained only by the phospholipid hydroperoxide (PLOOH)-reducing enzyme glutathione peroxidase 4 (GPX4)3,4 and radical-trapping antioxidants (RTAs)5,6. The factors which underlie a given cell type's sensitivity to ferroptosis7 are, however, cr…
  • Influence of Taxanes on Treatment Sequence in Gastric Cancer. [Review]
    Oncol Res Treat 2019; :1-6Lorenzen S, Stahl M, … Lordick F
  • CONCLUSIONS: In first-line treatment of advanced gastric cancer, taxanes in combination with a platinum- and 5-fluorouracil-based regimen are generally not recommended because they lack a survival benefit and confer high toxicity. However, taxanes in first-line can be a treatment option for patients presenting with high tumor burden and strong pressure to achieve remission. Since the publication of several positive studies in second- and third-line therapy, sequential therapy is playing an increasingly important role in metastatic gastric and EGJ cancer. Key Message: Standard of care for the first-line treatment of gastric cancer is a platinum-fluoropyrimidine chemotherapy doublet combination. The standard of care after failure of platinum-based first-line therapy is ramucirumab in combination with paclitaxel. Data supporting this combination after previous taxane therapy are not yet available.
  • Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families. [Journal Article]
    Atherosclerosis 2019; 291:19-26Kuipers AL, Wojczynski MK, … Long-Life Family Study
  • CONCLUSIONS: We identified three chromosomal regions with evidence of linkage to carotid artery diameter and atherosclerotic plaque in exceptionally long-lived families. Since common allelic variants within our linkage peaks did not account for our findings, future follow-up resequencing of these regions in LLFS families should help advance our understanding of atherosclerosis, CVD, and healthy vascular aging.
  • Advanced theory of mind uniquely contributes to children's multiple-text comprehension. [Journal Article]
    J Exp Child Psychol 2019; 189:104708Florit E, De Carli P, … Mason L
  • This study examined the contribution of advanced theory of mind (AToM), operationalized as second- or higher-order recursive mentalistic reasoning, to multiple-text comprehension in fourth and fifth graders (N = 184). The role of AToM was analyzed by taking into account children's individual characteristics (i.e., age, gender, prior topic knowledge, word reading fluency, vocabulary knowledge, and…
  • Long-term Outcomes in Down Syndrome Children After Cochlear Implantation: Particular Issues and Considerations. [Journal Article]
    Otol Neurotol 2019Clarós P, Remjasz A, … Wiatrow A
  • CONCLUSIONS: The early cochlear implantation in children with DS is a similarly useful method in treating severe to profound sensorineural hearing loss (SNHL) as in non-syndromic patients, although the development of speech skills present differently. Due to a higher prevalence of ear and temporal bone malformations, detailed diagnostic imaging should be taken into account before the CI qualification. Better postoperative outcomes may be achieved through comprehensive care from parents/guardians and speech therapists thanks to intensive and systematic rehabilitation.
  • Perinatal complications and live-birth outcomes following assisted reproductive technology: a retrospective cohort study. [Journal Article]
    Chin Med J (Engl) 2019Lei LL, Lan YL, … Zhai ZJ
  • CONCLUSIONS: This retrospective cohort study demonstrated that patients who underwent ART were at increased risk of several adverse pregnancy outcomes compared with women who conceived spontaneously. These complications may be attributed in part to the relatively high multiple pregnancy rate after ART. Elective single embryo transfer should be promoted in China to reduce the obstetrical risks of ART pregnancy. Singletons of ART pregnancy exhibited increased maternal and neonatal complications as well, suggesting that underlying infertility or other maternal or parental factors may contribute to the adverse outcomes.
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