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1,154 results
  • Aqueous liquid chromatography with mobile phases of sodium dodecyl sulphate and ionic liquid. [Journal Article]
    J Chromatogr A. 2023 Jan 25; 1689:463740.Tereba-Mamani CJ, Janczuk MA, … García-Alvarez-Coque MC
  • In conventional reversed-phase liquid chromatography (RPLC) with hydro-organic solvents, basic cationic solutes yield retained, broad, asymmetric peaks, owing to their interaction with free anionic silanols in the stationary phase. RPLC mobile phases to which the anionic surfactant sodium dodecyl sulphate (SDS), or an ionic liquid (IL) are added, have been proposed as solutions, since these addit…
  • Hydrogen-deuterium (H/D) exchange reaction of acebutolol hydrochloride in D₂O and CD₃OD solution. [Journal Article]
    Pharmazie. 2022 09 01; 77(7):217-223.Guesmi H, Kraim JB, … Holzgrabe U
  • H/D exchange reactions can be observed by NMR spectroscopy of acebutolol (ACE). The results obtained showed deuterium incorporation at α-posi t ion of the carbonyl group of acebutolol, when using deuterium oxide or deuterated methanol as deuterium source and solvent. The spontaneous deuteration is proceeded by the following pathway CH₃→CH₂D→CHD→CD₃, through a keto-enol tautomerization reaction. F…
  • StatPearls: Selective Beta-1-Blockers [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)TuckerWilliam D.WDETSU Quillen College of MedicineSankarParvathyPMichigan State University College of Osteopathic MedicineTheetha KariyannaPramodPState Un of New York - Downstate MCBOOK
  • The cardio-selective beta-1-blockers include atenolol, betaxolol, bisoprolol, esmolol, acebutolol, metoprolol, and nebivolol. FDA approved uses of beta-1-selective blockers include hypertension, chronic stable angina, heart failure, post-myocardial infarction, and decreased left ventricular function after a recent myocardial infarction. Non-FDA approved uses include migraine prophylaxis, treatmen…
  • Drugs and Lactation Database (LactMed): Acebutolol [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because of the relatively extensive excretion of acebutolol and its active metabolite diacetolol into breastmilk and some possible reports of adverse reactions in breastfed infants, other agents are preferred, especially while nursing a newborn or preterm infant.[1-3]
  • Performance and modelling of retention in microemulsion liquid chromatography. [Journal Article]
    J Chromatogr A. 2020 Dec 20; 1634:461651.Pankajkumar-Patel N, Peris-García E, … García-Alvarez-Coque MC
  • The capability of liquid chromatography with microemulsions (MEs) as mobile phases was studied for the analysis of four parabens (butylparaben, ethylparaben, methylparaben, and propylparaben) and seven β-adrenoceptor antagonists (acebutolol, atenolol, carteolol, metoprolol, oxprenolol, propranolol, and timolol). MEs were formed by mixing aqueous solutions of the anionic surfactant sodium dodecyl …
  • Time course for blood pressure lowering of beta-blockers with partial agonist activity. [Meta-Analysis]
    Cochrane Database Syst Rev. 2020 09 05; 9:CD010054.Zhang XY, Soufi S, … Musini VM
  • CONCLUSIONS: There is insufficient evidence to draw general conclusions about the degree of variation in hourly BP-lowering efficacy of BBPAA over a 24-hour period, in adults with essential hypertension. Very low-certainty evidence showed that BBPAA acebutalol, pindolol, and bopindolol lowered BP more during the day and evening than at night. However, the number of studies and participants included in this review was very small, further limiting the certainty of the evidence. We need further and larger trials, with accurate recording of time of drug intake, and with reporting of standard deviation of BP and HR at each hour.
  • β-blocker therapy for infantile hemangioma. [Review]
    Expert Rev Clin Pharmacol. 2020 Aug; 13(8):899-915.Koh SP, Leadbitter P, … Tan ST
  • CONCLUSIONS: Improved understanding of the biology of IH provides insights into the mechanism of action underscoring its accelerated involution induced by propranolol, other β-blockers and ACE inhibitors. More research is required to understand the optimal dosing and duration, efficacy and safety of these alternative therapies. Recent demonstration of propranolol's actions mediated by non-β-adrenergic isomer R-propranolol on stem cells, offers an immense opportunity to harness the efficacy of β-blockers to induce accelerated involution of IH, while mitigating their β-adrenergic receptor-mediated adverse effects.
  • N-Aryl Amides as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents. [Journal Article]
    Chemistry. 2020 Sep 10; 26(51):11705-11709.Cai X, Zhang J, … Liu G
  • Chemical exchange saturation transfer (CEST) MRI has recently emerged as a versatile molecular imaging approach in which diamagnetic compounds can be utilized to generate an MRI signal. To expand the scope of CEST MRI applications, herein, we systematically investigated the CEST properties of N-aryl amides with different N-aromatic substitution, revealing their chemical shifts (4.6-5.8 ppm) and e…
  • Enantiospecific behaviour of chiral drugs in soil. [Journal Article]
    Environ Pollut. 2020 Jul; 262:114364.Bertin S, Yates K, Petrie B
  • The importance of stereochemistry on the behaviour and effects of chiral pharmaceutical and illicit drugs in amended agricultural soils has been over looked to date. Therefore, this study was aimed at investigating the enantiospecific behaviour of a chemically diverse range of chiral drugs including naproxen, ibuprofen, salbutamol, bisoprolol, metoprolol, propranolol, acebutolol, atenolol, chlorp…
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