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(acetaminophen oral rectal )
131 results
  • Bioavailability of suppository acetaminophen in healthy and hospitalized ill dogs. [Journal Article]
    J Vet Pharmacol Ther 2018; 41(5):652-658Sikina ER, Bach JF, … KuKanich B
  • To determine the plasma pharmacokinetics of suppository acetaminophen (APAP) in healthy dogs and clinically ill dogs. This prospective study used six healthy client-owned and 20 clinically ill hospitalized dogs. The healthy dogs were randomized by coin flip to receive APAP orally or as a suppository in crossover study design. Blood samples were collected up to 10 hr after APAP dosing. The hospita…
  • Opioid Sparing in Cleft Palate Surgery. [Journal Article]
    Cleft Palate Craniofac J 2018; 55(9):1200-1204Carr L, Gray M, … Samson T
  • CONCLUSIONS: In this study, intraoperative administration of acetaminophen was associated with decreased pain scores, but no opioid-sparing effect. As other studies have shown an opioid-sparing effect with postoperative acetaminophen, we recommend withholding the intraoperative dose and beginning therapy in the immediate postoperative period.
  • Tramadol with or without paracetamol (acetaminophen) for cancer pain. [Review]
    Cochrane Database Syst Rev 2017; 5:CD012508Wiffen PJ, Derry S, Moore RA
  • CONCLUSIONS: There is limited, very low quality, evidence from randomised controlled trials that tramadol produced pain relief in some adults with pain due to cancer and no evidence at all for children. There is very low quality evidence that it is not as effective as morphine. This review does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially different is very high. The place of tramadol in managing cancer pain and its role as step 2 of the WHO analgesic ladder is unclear.
  • Prophylactic drug management for febrile seizures in children. [Review]
    Cochrane Database Syst Rev 2017; 2:CD003031Offringa M, Newton R, … Nevitt SJ
  • CONCLUSIONS: We found reduced recurrence rates for children with febrile seizures for intermittent diazepam and continuous phenobarbitone, with adverse effects in up to 30%. Apparent benefit for clobazam treatment in one trial needs to be replicated to be judged reliable. Given the benign nature of recurrent febrile seizures, and the high prevalence of adverse effects of these drugs, parents and families should be supported with adequate contact details of medical services and information on recurrence, first aid management and, most importantly, the benign nature of the phenomenon.
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