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(acetaminophen oral rectal )
133 results
  • Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. [Meta-Analysis]
    Cochrane Database Syst Rev. 2020 01 27; 1:CD011219.Ohlsson A, Shah PS
  • CONCLUSIONS: The paucity and low quality of existing data do not provide sufficient evidence to establish the role of paracetamol in reducing the effects of painful procedures in neonates. Paracetamol given after assisted vaginal birth may increase the response to later painful exposures. Paracetamol may reduce the total need for morphine following major surgery, and for this aspect of paracetamol use, further research is needed.
  • Bioavailability of suppository acetaminophen in healthy and hospitalized ill dogs. [Journal Article]
    J Vet Pharmacol Ther. 2018 Oct; 41(5):652-658.Sikina ER, Bach JF, … KuKanich B
  • To determine the plasma pharmacokinetics of suppository acetaminophen (APAP) in healthy dogs and clinically ill dogs. This prospective study used six healthy client-owned and 20 clinically ill hospitalized dogs. The healthy dogs were randomized by coin flip to receive APAP orally or as a suppository in crossover study design. Blood samples were collected up to 10 hr after APAP dosing. The hospita…
  • Opioid Sparing in Cleft Palate Surgery. [Journal Article]
    Cleft Palate Craniofac J. 2018 10; 55(9):1200-1204.Carr L, Gray M, … Samson T
  • CONCLUSIONS: In this study, intraoperative administration of acetaminophen was associated with decreased pain scores, but no opioid-sparing effect. As other studies have shown an opioid-sparing effect with postoperative acetaminophen, we recommend withholding the intraoperative dose and beginning therapy in the immediate postoperative period.
  • Tramadol with or without paracetamol (acetaminophen) for cancer pain. [Review]
    Cochrane Database Syst Rev. 2017 05 16; 5:CD012508.Wiffen PJ, Derry S, Moore RA
  • CONCLUSIONS: There is limited, very low quality, evidence from randomised controlled trials that tramadol produced pain relief in some adults with pain due to cancer and no evidence at all for children. There is very low quality evidence that it is not as effective as morphine. This review does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially different is very high. The place of tramadol in managing cancer pain and its role as step 2 of the WHO analgesic ladder is unclear.
  • Prophylactic drug management for febrile seizures in children. [Review]
    Cochrane Database Syst Rev. 2017 02 22; 2:CD003031.Offringa M, Newton R, … Nevitt SJ
  • CONCLUSIONS: We found reduced recurrence rates for children with febrile seizures for intermittent diazepam and continuous phenobarbitone, with adverse effects in up to 30%. Apparent benefit for clobazam treatment in one trial needs to be replicated to be judged reliable. Given the benign nature of recurrent febrile seizures, and the high prevalence of adverse effects of these drugs, parents and families should be supported with adequate contact details of medical services and information on recurrence, first aid management and, most importantly, the benign nature of the phenomenon.
  • Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. [Review]
    Cochrane Database Syst Rev. 2016 Oct 07; 10:CD011219.Ohlsson A, Shah PS
  • CONCLUSIONS: The paucity and low quality of existing data do not provide sufficient evidence to establish the role of paracetamol in reducing the effects of painful procedures in neonates. Paracetamol given after assisted vaginal birth may increase the response to later painful exposures. Paracetamol may reduce the total need for morphine following major surgery, and for this aspect of paracetamol use, further research is needed.
  • In-Plane Ultrasound-Guided Lumbar Plexus Block Using Catheter-Over-Needle Technique in a 14-Month-Old Baby. [Case Reports]
    Reg Anesth Pain Med. 2016 Jul-Aug; 41(4):538-41.Tognù A, Cauli V, … Bonarelli S
  • This case report details the feasibility of a continuous lumbar plexus block obtained with a paramedian transverse scan of the lumbar paravertebral region, using a catheter-over-needle system, as a main postoperative orthopedic analgesia, in a 14-month-old patient undergoing surgical treatment of a localized Ewing family tumor of the right proximal femur. After surgery, the patient remained in th…
  • Effect of Acetaminophen Ingestion on Thermoregulation of Normothermic, Non-febrile Humans. [Journal Article]
    Front Pharmacol. 2016; 7:54.Foster J, Mauger A, … Taylor L
  • In non-febrile mouse models, high dose acetaminophen administration causes profound hypothermia. However, this potentially hazardous side-effect has not been confirmed in non-febrile humans. Thus, we sought to ascertain whether an acute therapeutic dose (20 mg⋅kg lean body mass) of acetaminophen would reduce non-febrile human core temperature in a sub-neutral environment. Ten apparently healthy (…
  • Outpatient treatment of uncomplicated diverticulitis: a systematic review. [Review]
    Eur J Gastroenterol Hepatol. 2016 Jun; 28(6):622-7.Sánchez-Velázquez P, Grande L, Pera M
  • Acute diverticulitis occurs in up to 25% of patients with diverticulosis. The majority of cases are mild or uncomplicated and it has become a frequent reason for consultation in the emergency department. On the basis of the National Inpatient Sample database from the USA, 86% of patients admitted with diverticulitis were treated with medical therapy. However, several recent studies have shown tha…
  • Paracetamol (acetaminophen) for prevention or treatment of pain in newborns. [Review]
    Cochrane Database Syst Rev. 2015 Jun 25Ohlsson A, Shah PS
  • CONCLUSIONS: Paracetamol does not significantly reduce pain associated with heel lance or eye examinations. Paracetamol given after assisted vaginal birth may increase the response to later painful exposures. Paracetamol should not be used for painful procedures given its lack of efficacy and its potential for adverse effects. Paracetamol may reduce the total need for morphine following major surgery, and for this aspect of paracetamol use, further research is needed.
  • Acetaminophen by infusion. [Journal Article]
    Orthop Nurs. 2015 May-Jun; 34(3):166-9; quiz 170-1.Turkoski BB
  • Acetaminophen is a nonsteroidal, nonsalicylate analgesic and antipyretic that is, today, the most common medication ingredient found in oral and rectal over-the-counter and prescription drugs. However, it was not until 2010 that Ofirmev (acetaminophen), an injection form of acetaminophen, was approved for treating mild to moderate pain, as an adjunct to opioids for severe pain, and reduction of f…
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