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9,835 results
  • Carbonic anhydrase II deficiency. [Journal Article]
    Bone. 2023 Jan 26 [Online ahead of print]Whyte MP
  • Carbonic anhydrase II deficiency (OMIM # 259730), initially called "osteopetrosis with renal tubular acidosis and cerebral calcification syndrome", reveals an important role for the enzyme carbonic anhydrase II (CA II) in osteoclast and renal tubule function. Discovered in 1972 and subsequently given various names, CA II deficiency now describes >100 affected individuals encountered predominantly…
  • Pseudotumor Cerebri Postpartum: A Case Report. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32893.Msheik A, Atat R, Al Arab S
  • Idiopathic intracranial hypertension (IIH), called pseudotumor cerebri, could cause postpartum headaches. Generally, this diagnosis is idiopathic and treatment is mainly medical to avoid serious complications of possible vision loss. In this paper, we report the case of a 24-year-old lady who developed a similar constellation of symptoms and was diagnosed with this condition. Postpartum, the pati…
  • A Case Study on the Use of Binding Free Energies to Screen Inhibitors of Human Carbonic Anhydrase II. [Journal Article]
    Chemphyschem. 2023 Jan 25 [Online ahead of print]Khatua S, De Bhowmik T, Taraphder S
  • We present in this article a case study on the thermodynamics of binding to human carbonic anhydrase II (HCA II) by three well-known inhibitors, viz. (a) acetazolamide (AZM) that directly binds to the catalytic Zn(II) ion at the active site, (b) non-zinc binding 6-hydroxy-2-thioxocoumarin (FC5) (c) 2-[(S)-benzylsulfinyl]benzoic acid (3G1). In each case, the crystal structure or its analogue of in…
  • Flying to high-altitude destinations: is the risk of acute mountain sickness greater? [Journal Article]
    J Travel Med. 2023 Jan 25 [Online ahead of print]Burtscher J, Swenson ER, … Burtscher M
  • CONCLUSIONS: Due to the short time span in going from low to high altitude, reduced acclimatization likely is the main reason for a higher AMS risk when travelling to high altitude destinations by flight. To avoid frustrating travel experiences and health risks, appropriate and timely medical advice on how to prepare for air travel to high-altitude is of vital importance. Effective preparation options include the use of modern pre-acclimatization strategies and pharmacological prophylaxis by acetazolamide or dexamethasone, or even considering alternate itineraries with more gradual ascent.
  • Acetazolamide for Bipolar Disorders: A Scoping Review. [Review]
    Brain Sci. 2023 Jan 13; 13(1)Strawbridge R, Yalin N, … Young AH
  • Acetazolamide, a carbonic anhydrase inhibitor, is used to treat a variety of ailments. It has been highlighted for its potential to benefit people with bipolar disorders, for whom there are clear current unmet treatment needs. This scoping review sought to synthesise all available evidence related to the potential effects of acetazolamide on symptoms related to bipolar disorder, acceptability and…
  • Interaction Between the Glymphatic System and α-Synuclein in Parkinson's Disease. [Journal Article]
    Mol Neurobiol. 2023 Jan 13 [Online ahead of print]Zhang Y, Zhang C, … Wang LH
  • The glymphatic system contributes to the clearance of amyloid-β from the brain and is disrupted in Alzheimer's disease. However, whether the system is involved in the removal of α-synuclein (α-syn) and whether it is suppressed in Parkinson's disease (PD) remain largely unknown. In mice receiving the intranigral injection of recombinant human α-syn, we found that the glymphatic suppression via aqu…
  • Resolution of Fulminant Idiopathic Intracranial Hypertension Treated with Acetazolamide. [Case Reports]
    Case Rep Neurol. 2022 Sep-Dec; 14(3):424-428.Srivastava O, Micieli JA
  • Idiopathic intracranial hypertension (IIH) is a condition of elevated intracranial pressure commonly seen in obese women of childbearing age. Fulminant IIH is a rare subset of IIH that is characterized by rapidly progressive vision loss in less than 4 weeks, and typically requires surgical intervention for treatment. We describe a 36-year-old man with a 3-week history of acute onset vision loss a…
  • Intraocular Pressure Elevation After Posterior Subtenon Triamcinolone Acetonide Injection in Pediatric Non-Infectious Uveitis. [Journal Article]
    Beyoglu Eye J. 2022; 7(4):298-303.Yalcinsoy KO, Ozdal PC, … Elgin U
  • CONCLUSIONS: In our study, an IOP elevation rate as high as 47% was found in pediatric non-infectious uveitis patients following only a single PSTA injection. Steroid-induced IOP elevation and resistant glaucoma can develop even after the first PSTA administration in pediatric uveitis. Filtration surgery and the excision of subtenon triamcinolone deposits, when present, are important in glaucoma management. The risk/benefit ratio must be carefully considered when administering steroid injections to children with uveitis.
  • CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options. [Journal Article]
    Handb Exp Pharmacol. 2023 Jan 03 [Online ahead of print]Indelicato E, Boesch S
  • In the last decade, variants in the Ca2+ channel gene CACNA1A emerged as a frequent aetiology of rare neurological phenotypes sharing a common denominator of variable paroxysmal manifestations and chronic cerebellar dysfunction. The spectrum of paroxysmal manifestations encompasses migraine with hemiplegic aura, episodic ataxia, epilepsy and paroxysmal non-epileptic movement disorders. Additional…
  • Acetazolamide-Induced Periorbital Myokymia: A Case Report. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31920.Raj A, Alapatt PJ, … V V A
  • Acetazolamide, a carbonic anhydrase inhibitor, is primarily used in the treatment of glaucoma, due to its role in decreasing intraocular pressure by lowering the production of aqueous humor. Additionally, by lowering cerebrospinal fluid (CSF) production, it is also used in the treatment of raised intracranial pressure. Drug-induced myokymia has rarely been reported, with known triggers being cloz…
  • Extreme intraocular pressure and steroid-dependent iritis. [Journal Article]
    J Cataract Refract Surg. 2023 01 01; 49(1):108-113.Samuelson TW, Huang MJ, … Do A
  • A 50-year-old ophthalmic technician was referred by her retina specialist for urgent consultation due to markedly elevated intraocular pressure (IOP) unresponsive to medical therapy. Her history included chronic polyarticular juvenile rheumatoid arthritis and chronic uveitis requiring ongoing topical steroid therapy. She had a sub-Tenon injection of Kenalog (triamcinolone) 18 months prior to refe…
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