Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.
298 results
  • Current Therapeutic Strategies of Xeroderma Pigmentosum. [Review]
    Indian J Dermatol. 2021 Nov-Dec; 66(6):660-667.Hossain M, Hasan A, … Jahan I
  • Xeroderma pigmentosum (XP) is an autosomal recessive genetic disease caused by a defect in the DNA repair system, exhibiting skin cancer on sun exposure. As it is an incurable disease, therapeutic strategies of this disease are critical. This review article takes an attempt to explore the current therapeutic advancements in XP. Different approaches including sun avoidance; surgical removal of can…
  • Modification of Drug Crystallization by Cyclodextrins in Pre-formulation Study. [Review]
    Chem Pharm Bull (Tokyo). 2019; 67(9):915-920.Iohara D, Anraku M, … Hirayama F
  • Controlling drug crystallization is one of the important issues in pre-formulation study. In recent years, advanced approaches including the use of tailor-made additives have gathered considerable attention to control crystallization behavior of drugs. This review focuses on the use of hydrophilic cyclodextrins (CDs) as additives for controlling drug crystallization. CDs affect the crystallizatio…
  • Sulfonylurea derivatives and cancer, friend or foe? [Journal Article]
    Eur J Pharmacol. 2019 Oct 15; 861:172598.Hendriks AM, Schrijnders D, … Landman GWD
  • Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to reduce cancer risk and progression, as has been demonstrated for the biguanide metformin in observation…
  • Drugs and Lactation Database (LactMed): Acetohexamide [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because no information is available on the use of acetohexamide during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose …
  • Novel therapeutic approaches to xeroderma pigmentosum. [Review]
    Br J Dermatol. 2019 08; 181(2):249-255.Weon JL, Glass DA
  • CONCLUSIONS: Clinical management of patients with xeroderma pigmentosum still focuses on preventative avoidance of sun exposure as opposed to therapies that would improve the patients' condition; thus, novel approaches to this disease are warranted.
  • Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH. [Journal Article]
    Mol Cell. 2017 Nov 16; 68(4):797-807.e7.Mazouzi A, Battistini F, … Loizou JI
  • DNA lesions caused by UV damage are thought to be repaired solely by the nucleotide excision repair (NER) pathway in human cells. Patients carrying mutations within genes functioning in this pathway display a range of pathologies, including an increased susceptibility to cancer, premature aging, and neurological defects. There are currently no curative therapies available. Here we performed a hig…
  • Effects of Fatty Acids and Glycation on Drug Interactions with Human Serum Albumin. [Journal Article]
    Curr Metabolomics. 2013 Sep 01; 1(3):239-250.Anguizola JA, Basiaga SB, Hage DS
  • The presence of elevated glucose concentrations in diabetes is a metabolic change that leads to an increase in the amount of non-enzymatic glycation that occurs for serum proteins. One protein that is affected by this process is the main serum protein, human serum albumin (HSA), which is also an important carrier agent for many drugs and fatty acids in the circulatory system. Sulfonylureas drugs,…
  • Epac2: a sulfonylurea receptor? [Journal Article]
    Biochem Soc Trans. 2012 Feb; 40(1):6-10.Rehmann H
  • Sulfonylureas are widely used oral drugs in the treatment of diabetes mellitus. They function by the inhibition of ATP-sensitive K+ channels in pancreatic β-cells, which are thus considered the 'classical' sulfonylurea receptor. Next to the ATP-sensitive K+ channels, additional sulfonylurea-interacting proteins were identified, which might contribute to the physiological effects of this drug fami…
  • Chromatographic analysis of acetohexamide binding to glycated human serum albumin. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15; 878(28):2775-81.Joseph KS, Anguizola J, … Hage DS
  • Acetohexamide is a drug used to treat type II diabetes and is tightly bound to the protein human serum albumin (HSA) in the circulation. It has been proposed that the binding of some drugs with HSA can be affected by the non-enzymatic glycation of this protein. This study used high-performance affinity chromatography to examine the changes in acetohexamide-HSA binding that take place as the glyca…
  • Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jun 01; 878(19):1590-8.Joseph KS, Hage DS
  • Sulfonylurea drugs are often prescribed as a treatment for type II diabetes to help lower blood sugar levels by stimulating insulin secretion. These drugs are believed to primarily bind in blood to human serum albumin (HSA). This study used high-performance affinity chromatography (HPAC) to examine the binding of sulfonylureas to HSA. Frontal analysis with an immobilized HSA column was used to de…
  • [Studies for analyzing the prohibited ingredients such as acetohexamide in cosmetics]. [Journal Article]
    Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2005Tokunaga H, Uchino T
  • Acetohexamide (AH) is nominated as the prohibited ingredients in cosmetics in Japanese Pharmaceutical Affairs Act. So the analytical method for AH was investigated by HPLC. The lotion or milky lotion of 0.5g was put into a 10-ml volumetric flask. After adding 1.0ml of AH solution at 50 microg/ml into the volumetric flask, the mixture was made up to 10ml with methanol as the testing solution. Crea…
New Search Next