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Unbound Medicine.
(acetylcysteine)
21,236 results
  • Zearalenone induces oxidative stress and autophagy in goat Sertoli cells. [Journal Article]
    Ecotoxicol Environ Saf. 2023 Jan 26; 252:114571.Liu X, Xi H, … Hu J
  • Zearalenone (ZEA), one of the non-steroidal estrogen mycotoxin, can cause male reproductive damage and genotoxicity in mammals. Testicular oxidative injury is an important factor causing male sterility. Testicular Sertoli cells are essential for spermatogenesis and male fertility. At present, the mechanism of oxidative injury in dairy goat Sertoli cells after exposure to ZEA remains unclear. This…
  • Chest physiotherapy for mechanically ventilated children: a survey of current UK practice. [Journal Article]
    Physiotherapy. 2022 Nov 18; 119:17-25.Shkurka E, Wray J, … Shannon H
  • CONCLUSIONS: A range of chest physiotherapy treatments and adjuncts were used with ventilated children. Variation was apparent and may be due to individual preferences of those training staff or local policies. Pragmatic, interventional studies are required to determine best practice. Further exploration is necessary to understand the variation in practice and intricacies of decision making.
  • Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury. [Journal Article]
    Front Pharmacol. 2022; 13:1084799.Huang Z, Wang H, … Zhao Y
  • Acetaminophen (N-acetyl-p-aminophenol, APAP) is a common antipyretic agent and analgesic. An overdose of APAP can result in acute liver injury (ALI). Oxidative stress and inflammation are central to liver injury. N-acetylcysteine (NAC), a precursor of glutathione, is used commonly in clinical settings. However, the window of NAC treatment is limited, and more efficacious alternatives must be foun…
  • Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization. [Journal Article]
    Pharmaceuticals (Basel). 2023 Jan 03; 16(1)Primas N, Lano G, … Vanelle P
  • Parenteral N-acetylcysteine has a wide variety of clinical applications, but its use can be limited by a poor chemical stability. We managed to control parenteral N-acetylcysteine stability, and to study the influence of additives on the decrease of N-acetylcysteine degradation. First, an HPLC-UV dosing method of N-acetylcysteine and its main degradation product, a dimer, was validated and the st…
  • Treatment of Drug-Induced Liver Injury. [Review]
    Biomedicines. 2022 Dec 21; 11(1)Teschke R
  • Current pharmacotherapy options of drug-induced liver injury (DILI) remain under discussion and are now evaluated in this analysis. Needless to say, the use of the offending drug must be stopped as soon as DILI is suspected. Normal dosed drugs may cause idiosyncratic DILI, and drugs taken in overdose commonly lead to intrinsic DILI. Empirically used but not substantiated regarding efficiency by r…
  • Sex Differences in X-ray-Induced Endothelial Damage: Effect of Taurine and N-Acetylcysteine. [Journal Article]
    Antioxidants (Basel). 2022 Dec 29; 12(1)Campesi I, Brunetti A, … Franconi F
  • Ionizing radiation (IR) can induce some associated pathological conditions due to numerous cell damages. The influence of sex is scarcely known, and even less known is whether the effect of antioxidants is sex-dependent. Given the increased use of IR, we investigated whether male human umbilical vein endothelial cells (MHUVECs) and female human umbilical vein endothelial cells (FHUVECs) respond d…
  • The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets. [Review]
    Exp Biol Med (Maywood). 2023 Jan 20 [Online ahead of print]Luo G, Huang L, Zhang Z
  • Acetaminophen (APAP), a widely used antipyretic and analgesic drug in clinics, is relatively safe at therapeutic doses; however, APAP overdose may lead to fatal acute liver injury. Currently, N-acetylcysteine (NAC) is clinically used as the main antidote for APAP poisoning, but its therapeutic effect remains limited owing to rapid disease progression and the general diagnosis of advanced poisonin…
  • Analysis of SOD1 Variants in Chinese Patients with Familial Amyotrophic Lateral Sclerosis. [Journal Article]
    QJM. 2023 Jan 20 [Online ahead of print]Li H, Yuan L, … Deng H
  • CONCLUSIONS: This study identified three SOD1 variants in three families with FALS. The variant SOD1 toxicity was associated with oxidative damage and aggregation, and N-acetylcysteine could rescue the decreased cell viability induced by these variants. Our findings support a pathogenic role for ROS in SOD1 deficiencies, and provide a potential drug N-acetylcysteine for ALS therapy, especially in SOD1-patients with limb onset.
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