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(acetylfentanyl acetyl fentanyl acetyl fentanyl)
21 results
  • Synthetic Opioids. [Review]
    Handb Exp Pharmacol 2018; 252:353-381Beardsley PM, Zhang Y
  • Opioid abuse has been a global menace for centuries, but the proliferation of synthetic opioids and their use within this current decade have created epidemic-level harms in some countries. According to the United Nations Office on Drugs and Crime, almost 12 million years were estimated loss of "healthy" life resulting in premature death and disability attributable to global opioid abuse just in …
  • Acetyl Fentanyl: Trends and Concentrations in Metro Detroit. [Journal Article]
    J Forensic Sci 2019; 64(1):149-153Avedschmidt S, Schmidt C, … Gupta A
  • Acetyl fentanyl (N-[1-phenethylpiperidin-4-yl]-N-phenylacetamide) is a potent opioid analgesic with no medicinal uses. We report deaths between 2016 and 2017 at the Medical Examiner's Office in Detroit, MI where acetyl fentanyl was found in the decedent's blood and compare them to previously published deaths between 2015 and 2016. The recent cases (cohort B) had a mean acetyl fentanyl concentrati…
  • Analytical Approaches in Fatal Intoxication Cases Involving New Synthetic Opioids. [Review]
    Curr Pharm Biotechnol 2018; 19(2):113-123Gerace E, Salomone A, Vincenti M
  • CONCLUSIONS: As a consequence, the detection of these compounds in biological samples is crucial in order to get a better understanding of their concentration and distribution in body fluids. We overviewed the analytical approaches for the investigation of synthetic opioids in postmortem samples reported in the literature, with special emphasis given to cases of lethal intoxication.
  • Metabolism of Fentanyl and Acetylfentanyl in Human-Induced Pluripotent Stem Cell-Derived Hepatocytes. [Journal Article]
    Biol Pharm Bull 2018; 41(1):106-114Kanamori T, Togawa Iwata Y, … Inoue H
  • To evaluate the capability of human-induced pluripotent stem cell-derived hepatocytes (h-iPS-HEP) in drug metabolism, the profiles of the metabolites of fentanyl, a powerful synthetic opioid, and acetylfentanyl, an N-acetyl analog of fentanyl, in the cells were determined and analyzed. Commercially available h-iPS-HEP were incubated with fentanyl or acetylfentanyl for 24 or 48 h. After enzymatic …
  • Schedules of Controlled Substances: Placement of Acetyl Fentanyl Into Schedule I. Final order. [Journal Article]
    Fed Regist 2017; 82(108):26349-51Drug Enforcement Administration, Department of Justice
  • With the issuance of this final order, the Administrator of the Drug Enforcement Administration will maintain the placement of the substance acetyl fentanyl (N-(1-phenethylpiperidin-4-yl)-N-phenylacetamide), including its isomers, esters, ethers, salts, and salts of isomers, esters and ethers, in schedule I of the Controlled Substances Act. This scheduling action is pursuant to the Controlled Sub…
  • Exploring synthetic heroin: Accounts of acetyl fentanyl use from a sample of dually diagnosed drug offenders. [Journal Article]
    Drug Alcohol Rev 2018; 37(1):121-127Miller JM, Stogner JM, … Blough S
  • CONCLUSIONS: Acetyl fentanyl is reaching heroin users, some of which administer it unknowingly. Regulation of acetyl fentanyl is recommended in all countries as is increasing public awareness that the substance is distinct from and being sold as heroin. [Miller JM, Stogner JM, Miller BL, Blough S. Exploring synthetic heroin: Accounts of acetyl fentanyl use from a sample of dually diagnosed drug offenders. Drug Alcohol Rev 2018;37:121-127].
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