- Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. [Review]Farm Hosp. 2023 Jan 27 [Online ahead of print]FH
- CONCLUSIONS: In this context of chronic treatments with teratogenic potential, it is necessary to highlight the importance of pregnancy planning to select the safest drug. Given the quality of the available data, it is still necessary to continuously update the information, as well as to promote observational studies of cohorts of pregnant patients and men of childbearing age, including prospective studies, in order to generate more scientific evidence.
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- Two for two: Dual therapy with erlotinib and acitretin for twins with severe keratoderma in Olmsted syndrome. [Journal Article]Pediatr Dermatol. 2023 Jan 29 [Online ahead of print]PD
- Olmsted syndrome (OS) is a rare genetic disorder, characterized by painful palmoplantar keratoderma (PPK), periorificial and intertriginous hyperkeratoses, and alopecia. Fewer than 75 cases have been described. Variants in TRPV3 result in constitutive activation of transient receptor potential vanilloid 3, leading to increased epidermal growth factor receptor (EGFR) signaling, palmoplantar epider…
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- Case report: Infantile generalized pustular psoriasis with IL36RN and CARD14 gene mutations. [Case Reports]
- Infantile pustular psoriasis (IPP) is an extremely rare skin disease associated with genetic factors. Gene mutations of IL36RN (interleukin-36 receptor antagonist), CARD14 (caspase recruitment family member 14), and AP1S1 (the σ1C subunit of the adaptor protein complex 1) had been identified to be involved in the pathogenesis of IPP. IPP usually develops with no preceding psoriasis vulgaris (PV) …
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- Netherton syndrome in a Bulgarian patient : Presentation of a case and an update of therapeutic options. [Journal Article]Wien Med Wochenschr. 2023 Jan 25 [Online ahead of print]WM
- Comel-Netherton syndrome, or Netherton syndrome (NS), is a rare chronic genetic skin condition affecting the daily life of patients, which often results in poorly developed social skills and anxiety. Genetic predisposition plays a key role alongside the clinical findings, and clinicians must be aware of it as it can mimic other well-known skin conditions. Diagnosis is challenging both clinically …
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- Liver Disease Among Patients with Psoriasis: The Malaysian Psoriasis Registry. [Journal Article]Clin Exp Dermatol. 2023 Jan 12 [Online ahead of print]CE
- CONCLUSIONS: The frequency of psoriasis patients with liver disease in MPR was 0.8%. Psoriasis patients with liver disease were more likely to be male, had a higher rate of co-morbidities, severe disease, nail and joint involvement than those without liver disease.
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- Pityriasis Rubra Pilaris After Moderna COVID-19 Vaccination: A Case Report and Literature Review. [Journal Article]Am J Dermatopathol. 2023 Jan 10 [Online ahead of print]AJ
- To date, over 60% of the world's population has received at least 1 dose of coronavirus disease 2019 (COVID-19) vaccination, with over 12 billion doses administered globally. Commonly reported adverse effects of COVID-19 vaccination include fever, headache, myalgia, and injection site reactions. The spectrum of documented cutaneous reactions after COVID-19 vaccination is broad; however, pityriasi…
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- Interleukin-17A Inhibitor Secukinumab Treatment in HIV-Positive Psoriasis Patient: A Case Report. [Case Reports]
- Psoriasis is an immune-mediated chronic inflammatory dermatosis influenced by hereditary and environmental factors. Human immunodeficiency virus (HIV) infection affects the immune system and exacerbates psoriatic lesions. We report the case of a 33-year-old male patient diagnosed with psoriasis vulgaris, psoriatic arthritis and HIV infection. Acitretin capsules, etanercept and high-active antiret…
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- The Effects of Acitretin on Insulin Resistance, Glucose Metabolism, and Lipid Levels in Patients with Psoriasis. [Journal Article]
- CONCLUSIONS: Acitretin therapy resulted in increased triglyceride. The effect of acitretin on glucose metabolism and insulin resistance maybe dependent on the dose and duration of therapy.
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- Current treatments and emerging therapies of human polyomavirus-associated skin diseases: a comprehensive review. [Review]Int J Dermatol. 2022 Dec 28 [Online ahead of print]IJ
- Since Merkel cell polyomavirus (MCPyV) was linked as the predominant etiology of Merkel cell carcinoma (MCC) in 2008, three additional human polyomaviruses (HPyV) have been definitively linked to cutaneous diseases-trichodysplasia spinulosa virus (TSPyV) and human polyomavirus 6 and 7 (HPyV6, HPyV7). TSPyV contributes to the development of trichodysplasia spinulosa (TS), and HPyV6/7 is associated…
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- Different clinical features of pediatric generalized pustular psoriasis in patients with or without IL36RN variants. [Journal Article]Dermatology. 2022 Dec 28 [Online ahead of print]D
- CONCLUSIONS: IL36RN variants are associated with GPP with ACH subtypes, an absence of concurrent PV, and a greater extent of severe inflammation. Acitretin was an effective treatment for patients in our study and mostly resulted in a marked response in our cohort.
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- Case report: Successful treatment of acute generalized pustular psoriasis of puerperium with secukinumab. [Case Reports]
- Generalized pustular psoriasis (GPP) is a rare and severe form of psoriasis presenting with erythematous, aseptic pustules. Common systemic symptoms include fever and myalgias. The presentation of GPP resembles acute generalized exanthematous pustulosis (AGEP). However, the treatment of these two pathologies differs. While AGEP is self-limiting and treated with topical corticosteroids and constra…
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- The Influence of Acitretin on Brain Lipidomics in Adolescent Mice-Implications for Pediatric and Adolescent Dermatological Therapy. [Journal Article]
- Administration of systemic retinoids such as acitretin has not been approved yet for pediatric patients. An adverse event of retinoid-therapy that occurs with lower prevalence in children than in adults is hyperlipidemia. This might be based on the lack of comorbidities in young patients, but must not be neglected. Especially for the development of the human brain up to young adulthood, dysbalanc…
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- Treatment of Reactive Keratoacanthomas with Acitretin Following Multiple Excisions and Mohs Surgery for Recurrent Squamous Cell Carcinoma. [Journal Article]J Drugs Dermatol. 2022 Dec 01; 21(12):1353-1354.JD
- Surgical intervention is seen as the gold standard in the treatment of Squamous cell carcinoma. Yet, in cases of recurrence, repeated surgical procedures may unwittingly foment the rise of reactive keratoacanthomas at the surgical margins or edge of a newly placed skin graft.
- Acute Generalized Pustular Psoriasis Developed Resistance to Adalimumab Was Successfully Treated with Narrowband Ultraviolet B and Acitretin: A Case Report. [Case Reports]
- Acute generalized pustular psoriasis (GPP) is a severe but rare variant of psoriasis, characterized by an acute eruption of extensive erythema with numerous non-follicular pustules. In rare cases, local pustular psoriasis like acrodermatitis continua of Hallopeau (ACH) may progress into acute GPP if improperly treated. ACH and GPP are rare in the clinic and their treatment is more complex and oft…
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- Successful Treatment of Severe Subcorneal Pustular Dermatosis with Adalimumab. [Case Reports]
- Subcorneal pustular dermatosis (SPD) is a rare, chronic pustular dermatosis. The pathogenesis of SPD has not been fully elucidated, but some studies have found that tumor necrosis factor (TNF)-α may be associated with its pathogenesis. Some patients with multidrug-resistant SPD have improved significantly after treatment with the anti-TNF-α agent (adalimumab). We present a case of a 28-year-old f…
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- An unusual case report of porokeratosis ptychotropica on the buttocks. [Case Reports]
- CONCLUSIONS: The case report highlights the need for awareness amongst dermatologists for porokeratosis ptychotropica as a differential diagnosis for pruritic papules in the gluteal fold.
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- In Vitro and Ex Vivo Evaluation of Fluocinolone Acetonide-Acitretin-Coloaded Nanostructured Lipid Carriers for Topical Treatment of Psoriasis. [Journal Article]
- Psoriasis is chronic autoimmune disease that affects 2-5% of the global population. Fluocinolone acetonide (FLU) and acitretin (ACT) are widely used antipsoriatic drugs that belong to BCS classes II and IV, respectively. FLU exhibits side effects, such as skin irritation and a burning sensation. ACT also shows adverse effects, such as gingivitis, teratogenic effects and xerophthalmia. In the pres…
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- Management of Nail Disease in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations. [Journal Article]J Rheumatol. 2022 Nov 01 [Online ahead of print]JR
- CONCLUSIONS: The highest strength of supporting evidence is for the recommendation of biologic agents including tumor necrosis factor inhibitors, and interleukin 12/23, 17, and 23 inhibitors.
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- An analysis of psoriasis hospitalisation in Thailand. [Journal Article]
- Psoriasis hospitalisation is not frequently reported. The objective of this study was to determine (1) the clinical, laboratory and treatment features of patients with psoriasis hospitalised due to flare-up and (2) other causes of admission of patients with psoriasis. We retrospectively reviewed data on 48 patients admitted due to psoriasis flare-up and 1908 patients with psoriasis admitted due t…
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- Acitretin plus macrolides and acitretin monotherapy in the management of hidradenitis suppurativa. [Letter]J Eur Acad Dermatol Venereol. 2022 Oct 28 [Online ahead of print]JE
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- The Use of Retinoids for the Prevention and Treatment of Skin Cancers: An Updated Review. [Review]
- Retinoids are natural and synthetic vitamin A derivatives that are effective for the prevention and the treatment of non-melanoma skin cancers (NMSC). NMSCs constitute a heterogenous group of non-melanocyte-derived skin cancers that impose substantial burdens on patients and healthcare systems. They include entities such as basal cell carcinoma and cutaneous squamous cell carcinoma (collectively …
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- Retinoid-associated myopia in dermatologic patients: a systematic review. [Case Reports]Cutan Ocul Toxicol. 2022 Dec; 41(4):318-322.CO
- CONCLUSIONS: Considering the current literature, it is not possible to define a clear correlation between the use of retinoids and the development or worsening of myopia. Some studies suggest that retinoids may cause a myopic shift and the pathophysiologyical mechanism is supported by some animal and in vitro studies, but there is a lack of large prospective and well-controlled studies. In case of ocular disturbances after retinoid use a prompt ophthalmological referral is advisable and in case of the detection of a myopic refractive error a relationship to retinoids should be ruled out, considering also other possible causes such as age and previous refractive status.
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- Multiple keratoacanthomas of Ferguson-Smith type. [Case Reports]
- We report a case of a 41-year-old male patient with no family history, presented with extensive multiple keratoacanthomas with disfiguring scars. The diagnosis of a sporadic form of Ferguson-Smith syndrome was made. Treatment with acitretin showed a marked response. Recognizing this syndrome is crucial. Early treatment helps avoid scar formation.
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- HLA-DQA1 and DQB1 Alleles are Associated with Acitretin Response in Patients with Psoriasis. [Journal Article]Front Biosci (Landmark Ed). 2022 09 28; 27(9):266.FB
- CONCLUSIONS: Our observations support the potential role of HLA-DQA1*:02:01 and DQB*:02:02 as pharmacogenetic markers of the acitretin response in patients with psoriasis.
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- Available Alternative Biologics and Disease Groups Influence Biologic Drug Survival in Patients with Psoriasis and Psoriatic Arthritis. [Journal Article]
- CONCLUSIONS: The availability of alternative biologics and disease groups affect biologic drug survival in patients with psoriasis and PsA.
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- Pityriasis rubra pilaris (type I) following administration of the BNT162b2 mRNA COVID-19 vaccine: Successful treatment with ustekinumab and acitretin. [Letter]Dermatol Ther. 2022 Dec; 35(12):e15899.DT
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- ALA-PDT combined with oral acitretin in the treatment of refractory condyloma acuminatum in anal canal. [Journal Article]Photodiagnosis Photodyn Ther. 2022 Dec; 40:103048.PP
- CONCLUSIONS: ALA-PDT combined with oral acitretin is effective and safe in the treatment of refractory CA in anal canal, and with further study may become an option for these patients.
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- Unilateral lichen planus with Blaschko line distribution: A case report. [Case Reports]
- CONCLUSIONS: Cases of LP involving multiple segments of the body along the Blaschko's lines with nail damage are rare.
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- StatPearls: Acitretin [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Acitretin belongs to a group of drugs known as retinoids. Retinoids include natural and synthetic compounds that have similar activity to vitamin A. Vitamin A helps regulate the immune system, impacts cellular growth, differentiation, proliferation, and plays a role in embryonic development. Other effects of retinoids include immunologic anti-inflammatory effects, induction of apoptosis, and inhi…