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769,427 results
  • Correction of the aprt Gene Using Repair-Polypurine Reverse Hoogsteen Hairpins in Mammalian Cells. [Journal Article]
    Mol Ther Nucleic Acids 2019; 19:683-695Félix AJ, Ciudad CJ, Noé V
  • In this study, we describe the correction of single-point mutations in mammalian cells by repair-polypurine reverse Hoogsteen hairpins (repair-PPRHs). These molecules consist of (1) a PPRH hairpin core that binds to a polypyrimidine target sequence in the double-stranded DNA (dsDNA), producing a triplex structure, and (2) an extension sequence homologous to the DNA sequence to be repaired but con…
  • Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss. [Journal Article]
    Hear Res 2020; 388:107880Chen GD, Daszynski DM, … Salvi R
  • Oxidative stress is a major contributor to noise-induced hearing loss, the most common cause of hearing loss among military personnel and young adults. HK-2 is a potent, orally-active, multifunctional, redox-modulating drug that has been shown to protect against a wide range of neurological disorders with no observed side effects. HK-2 protected cochlear HEI-OC1 cells against various forms of exp…
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