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4,630 results
  • Reconceptualising precision public health. [Journal Article]
    BMJ Open 2019; 9(9):e030279Olstad DL, McIntyre L
  • As currently conceived, precision public health is at risk of becoming precision medicine at a population level. This paper outlines a framework for precision public health that, in contrast to its current operationalisation, is consistent with public health principles because it integrates factors at all levels, while illuminating social position as a fundamental determinant of health and health…
  • Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantation. [Journal Article]
    Microbiome 2019; 7(1):131Ingham AC, Kielsen K, … Pamp SJ
  • CONCLUSIONS: We identify multivariate associations between specific microbial taxa, host immune markers, immune cell reconstitution, and clinical outcomes in relation to HSCT. Our findings encourage further investigations into establishing longitudinal surveillance of the intestinal microbiome and relevant immune markers, such as hBD2, in HSCT patients. Profiling of the microbiome may prove useful as a prognostic tool that could help identify patients at risk of poor immune reconstitution and adverse outcomes, such as aGvHD and death, upon HSCT, providing actionable information in guiding precision medicine.
  • The unpredictable journeys of spreading, sustaining and scaling healthcare innovations: a scoping review. [Review]
    Health Res Policy Syst 2019; 17(1):84Côté-Boileau É, Denis JL, … Sabean M
  • Innovation has the potential to improve the quality of care and health service delivery, but maximising the reach and impact of innovation to achieve large-scale health system transformation remains understudied. Interest is growing in three processes of the innovation journey within health systems, namely the spread, sustainability and scale-up (3S) of innovation. Recent reviews examine what we …
  • BTK inhibitors synergize with 5-FU to treat drug-resistant TP53-null colon cancers. [Journal Article]
    J Pathol 2019Lavitrano M, Ianzano L, … Grassilli E
  • Colorectal cancer is the fourth cause of death from cancer worldwide mainly due to the high incidence of drug-resistance. During a screen for new actionable targets in drug-resistant tumours we recently identified p65BTK - a novel oncogenic isoform of Bruton's tyrosine kinase. Studying three different cohorts of patients here we show that p65BTK expression correlates with histotype and cancer pro…
  • Proteomics advances for precision therapy in ovarian cancer. [Journal Article]
    Expert Rev Proteomics 2019; :1-10Labrie M, Kendsersky ND, … Mills GB
  • Introduction: Due to the relatively low mutation rate and high frequency of copy number variation, finding actionable genetic drivers of high-grade serous carcinoma (HGSC) is a challenging task. Furthermore, emerging studies show that genetic alterations are frequently poorly represented at the protein level adding a layer of complexity. With improvements in large-scale proteomic technologies, pr…
  • HGF/MET pathway aberrations as diagnostic, prognostic, and predictive biomarkers in human cancers. [Journal Article]
    Crit Rev Clin Lab Sci 2019; :1-34Moosavi F, Giovannetti E, … Firuzi O
  • Cancer is a major cause of death worldwide. MET tyrosine kinase receptor [MET, c-MET, hepatocyte growth factor (HGF) receptor] pathway activation is associated with the appearance of several hallmarks of cancer. The HGF/MET pathway has emerged as an important actionable target across many solid tumors; therefore, biomarker discovery becomes essential in order to guide clinical intervention and pa…
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