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7,036 results
  • Coordinating Septum Formation and the Actomyosin Ring during Cytokinesis inSchizosaccharomyces pombe. [Review]
    Mol Microbiol 2019Hercyk BS, Onwubiko UN, Das ME
  • During cytokinesis, animal and fungal cells form a membrane furrow via actomyosin ring constriction. Our understanding of actomyosin ring-driven cytokinesis stems extensively from the fission yeast model system. However, unlike animal cells, actomyosin ring constriction occurs simultaneously with septum formation in fungi. While the formation of an actomyosin ring is essential for cytokinesis in …
  • The fusogenic synapse at a glance. [Review]
    J Cell Sci 2019; 132(18)Kim JH, Chen EH
  • Cell-cell fusion is a fundamental process underlying fertilization, development, regeneration and physiology of metazoans. It is a multi-step process involving cell recognition and adhesion, actin cytoskeletal rearrangements, fusogen engagement, lipid mixing and fusion pore formation, ultimately resulting in the integration of two fusion partners. Here, we focus on the asymmetric actin cytoskelet…
  • Single molecule mechanics resolves the earliest events in force generation by cardiac myosin. [Journal Article]
    Elife 2019; 8Woody MS, Winkelmann DA, … Goldman YE
  • Key steps of cardiac mechanochemistry, including the force-generating working stroke and the release of phosphate (Pi), occur rapidly after myosin-actin attachment. An ultra-high-speed optical trap enabled direct observation of the timing and amplitude of the working stroke, which can occur within <200 μs of actin binding by β-cardiac myosin. The initial actomyosin state can sustain loads of at l…
  • Role of intrinsic disorder in muscle sarcomeres. [Journal Article]
    Prog Mol Biol Transl Sci 2019; 166:311-340Tolkatchev D, Smith GE, Kostyukova AS
  • The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein C (MyBP-C). These two types of sarcomeric proteins represent very different but strongly interdependent functions, being responsible for maintaining structure and operation of the …
  • Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis. [Journal Article]
    J Cell Sci 2019Singh D, Odedra D, … Pohl C
  • During animal development, cells need to sense and adapt to mechanical forces from their environment. Ultimately, these forces are transduced through the actomyosin cortex. How the cortex simultaneously responds to and creates forces during cytokinesis is not well understood. Here we show that under mechanical stress, cortical actomyosin flow switches polarization during cytokinesis in the C. ele…
  • Role of dynamic nuclear deformation on genomic architecture reorganization. [Journal Article]
    PLoS Comput Biol 2019; 15(9):e1007289Seirin-Lee S, Osakada F, … Ochiai H
  • Higher-order genomic architecture varies according to cell type and changes dramatically during differentiation. One of the remarkable examples of spatial genomic reorganization is the rod photoreceptor cell differentiation in nocturnal mammals. The inverted nuclear architecture found in adult mouse rod cells is formed through the reorganization of the conventional architecture during terminal di…
  • Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. [Journal Article]
    Elife 2019; 8Cayuso J, Xu Q, … Wilkinson DG
  • The segregation of cells with distinct regional identity underlies formation of a sharp border, which in some tissues serves to organise a boundary signaling centre. It is unclear whether or how border sharpness is coordinated with induction of boundary-specific gene expression. We show that forward signaling of EphA4 is required for border sharpening and induction of boundary cells in the zebraf…
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