- The Value of MicroRNAs as an Indicator of the Severity and the Acute Phase of Spinal Cord Injury. [Journal Article]
- ARAnn Rehabil Med 2019; 43(3):328-334
- CONCLUSIONS: Expression levels of miRNA-21 and miRNA-223 might be associated with the severity and acute phase of SCI, respectively. It is mandatory, however, to analyze changes in levels of inflammatory markers and the relevant biological pathways.
- Toxoplasma Serology Status and Risk of Miscarriage, A Case-Control Study among Women with A History of Spontaneous Abortion. [Journal Article]
- IJInt J Fertil Steril 2019; 13(3):184-189
- CONCLUSIONS: Maternal acute toxoplasmosis during pregnancy is raised as one of the factors that increase the chance of spontaneous abortion. The necessary health training, especially on the parasite transmission ways to women before marriage, as well as the serological test in women before and during pregnancy is recommended. Polymerase chain reaction (PCR) and IgG avidity assays should be performed in the medical diagnostic laboratories for accurate distinguishing of the initial infection of toxoplasmosis in the pregnant women.
- LncRNA SNHG1 overexpression regulates the proliferation of acute myeloid leukemia cells through miR-488-5p/NUP205 axis. [Journal Article]
- EREur Rev Med Pharmacol Sci 2019; 23(13):5896-5903
- CONCLUSIONS: LncRNA SNHG1 promotes the development of AML through miR-488-5p/NUP205 axis.
- Biological responses following one-stage full-mouth scaling and root planing with and without azithromycin: Multicenter randomized trial. [Journal Article]
- JPJ Periodontal Res 2019 Jul 10
- CONCLUSIONS: FM-SRP resulted in similar improvements in clinical parameters with and without the use of AZM. Inflammatory mediators showed no difference between the two groups after FM-SRP treatment. The use of AZM was effective in preventing the elevation of body temperature after FM-SRP.
- Heat-killed Salmonella Typhimurium mitigated Radiation-induced Lung Injury. [Journal Article]
- CEClin Exp Pharmacol Physiol 2019 Jul 10
- Radiation-induced lung injury (RILI) is a serious complication in thoracic tumor radiotherapy. It often occurs in clinical chest radiotherapy and acute whole-body irradiation (WBI) caused by nuclear …
Radiation-induced lung injury (RILI) is a serious complication in thoracic tumor radiotherapy. It often occurs in clinical chest radiotherapy and acute whole-body irradiation (WBI) caused by nuclear accidents or nuclear weapon attack. Some radioprotective agents have been reported to exert protective effects when given prior to radiation exposure, however, there is no treatment strategy available for preventing RILI. In this study, we demonstrated that Heat-killed Salmonella typhimurium (HKST), a co-agonist of Toll-like receptors 2 (TLR2), Toll-like receptors 4 (TLR4) and Toll-like receptors 5 (TLR5), mitigated radiation-induced lung injury through transforming growth factor-β (TGF-β) signaling pathway. We found that HKST alleviated lung hyperaemia and pathological damage after irradiation, indicated that HKST inhibits the early inflammatory reaction of radiation-induced lung injury. Then, for the first time, we observed HKST reduced collagen deposit induced by irradiation in the later phase (7 to 14 week) of RILI, and we found that HKST inhibited radiation-induced cell apoptosis in lung tissues. We found that HKST reduced the level of TGF-β and regulated its downstream signaling pathway. Finally, it was found that HKST inhibited radiation-induced epithelial-mesenchymal transition (EMT) in lung tissues. In conclusion, our data showed that HKST effectively mitigated RILI through regulating TGF-β, provide novel treatment strategy for RILI in whole body irradiation and radiotherapy. This article is protected by copyright. All rights reserved.
- The Inflammatory Response to Surgery in Sickle Cell Disease Patients Undergoing Cholecystectomy. [Journal Article]
- JSLSJSLS 2019 Apr-Jun; 23(2)
- CONCLUSIONS: This exploratory study found an enhanced inflammatory response to cholecystectomy in patients with SCA compared with patients with HbAA. Minimally invasive surgical strategies for this patient group may help to mediate this response.
- Cardiac involvement in trypanosomiasis in sheep experimentally infected by Trypanosoma vivax (Ziemman, 1905). [Journal Article]
- EPExp Parasitol 2019 Jul 04
- The objective of the present study was to evaluate the clinical signs, electrocardiographic signs and evolution of histopathological lesions in the heart of sheep experimentally infected by Trypanoso…
The objective of the present study was to evaluate the clinical signs, electrocardiographic signs and evolution of histopathological lesions in the heart of sheep experimentally infected by Trypanosoma vivax during the acute and chronic phases of infection as well as to investigate the presence of parasitic DNA in the heart using polymerase chain reaction (PCR). Twenty-two male sheep were divided into the following four groups: G1, which consisted of six sheep infected by T. vivax that were evaluated until 20 days post-infection (dpi; acute phase); G2, which consisted of six sheep infected by T. vivax that were evaluated until 90 dpi (chronic phase); and G3 and G4 groups, which each consisted of five uninfected sheep. At the end of the experimental period, electrocardiographic evaluations and necroscopic examinations were performed. Fragments of the heart were collected and stained by Hematoxylin-Eosin and Masson's trichrome, and the fragments were also evaluated by PCR for T. vivax. G2 animals presented clinical signs suggestive of heart failure and electrocardiogram alterations characterized by prolonged P, T and QRS complex durations as well as by a cardiac electrical axis shift to the left and increased heart rate. In these animals, mononuclear multifocal myocarditis and interstitial fibrosis were also observed. PCR revealed positivity for T. vivax in two G1 animals and in all G2 animals. Thus, these findings suggested that T. vivax is responsible for the occurrence of cardiac lesions, which are related to heart failure, electrocardiographic alterations and mortality of the infected animals.
- Acute toxicity evolution during ozonation of mono-chlorophenols and initial identification of highly toxic intermediates. [Journal Article]
- ESEnviron Sci Process Impacts 2019 Jul 03
- Acute toxicity changes during ozonation of 2-chlorophenol (2-CP), 3-chlorophenol (3-CP) and 4-chlorophenol (4-CP) under various conditions were studied using the luminescence inhibition test. Though …
Acute toxicity changes during ozonation of 2-chlorophenol (2-CP), 3-chlorophenol (3-CP) and 4-chlorophenol (4-CP) under various conditions were studied using the luminescence inhibition test. Though the concentrations of mono-chlorophenols (CPs) and TOC decreased constantly, the acute toxicity evidently increased with reaction time until a maximum value was reached during ozonation of 2-CP at pH 3 to 7, 3-CP at pH 3 to 10, and 4-CP at pH 3 and 5. Principal component analysis (PCA) was applied to understand the relationships between acute toxicity and other physicochemical parameters. The intense interrelations between acute toxicity and SUVA280 were evident under all the pH conditions for 2-CP and 3-CP, and except at pH 12 for 4-CP, which implied that high-weight intermediates were formed and contributed to the increased toxicity. SUVA280 was a possible surrogate measure of acute toxicity during the ozonation of all three CPs. Profiling of acute toxicity in ozonated CPs was conducted using solid phase extraction with a series of different cartridges, high performance liquid chromatography (HPLC) fractionation and the luminescence inhibition bioassay. Considering the acute toxicity evolution under different conditions and profiles of acute toxicity in HPLC fractions, the highly toxic intermediates probably included same non-chlorine carboxylic acids though the three CPs had different substituent positions with higher polarity than their parent compounds. In this study, the acute toxicity evolution during ozonation of CPs and the forcing agents were thoroughly discussed. Therefore, ozonation is expected to be carefully operated and monitored, and toxicity tests should be used to evaluate whether effluent detoxification takes place.
- Trypanosoma cruzi circulating among dogs and triatomines in the endemic countryside of the State of Rio Grande do Norte, Brazil. [Journal Article]
- ATActa Trop 2019 Jun 27; :105067
- Vector transmission of Trypanosoma cruzi occurs in several areas of Brazil, including the northeastern region, and domestic animals can serve as reservoirs of the parasite. The aim of this study was …
Vector transmission of Trypanosoma cruzi occurs in several areas of Brazil, including the northeastern region, and domestic animals can serve as reservoirs of the parasite. The aim of this study was to monitor dogs as domestic reservoirs for infection by T. cruzi, and the main triatomine species involved in parasite transmission in rural areas of municipalities in the State of Rio Grande do Norte, in northeastern, Brazil. Blood samples from dogs (n = 40) and manual triatomine capture were performed in domiciliary and peridomiciliary environments in rural areas of the towns of Acari, Caraúbas and Marcelino Vieira, between 2013 and 2016. Subsequently, infection of dogs was determined by Polymerase Chain Reaction (PCR), Enzyme-Linked Immunosorbent Assay (ELISA) for the detection of IgM and IgG isotypes and Indirect Immunofluorescence (IIF) reactions for detection of IgG. Triatomine infection was determined by PCR. Forty (16/40) percent of the dogs were seropositive for T. cruzi; 20.0% (8/40) of such reactivity indicated the acute phase, and 20.0% (8/40), the chronic phase. PCR was positive in 42.5% (17/40) of the dogs' blood samples. Specimens of Triatoma brasiliensis, Triatoma pseudomaculata, Rhodnius nasutus and Panstrongylus lutzi were found to be infected; however only T. brasiliensis nymphs and adults were infected in both environments. Triatomines evaluation showed 82.5% (94/114) of PCR positivity. Taken together, our results confirm that dogs are domestic reservoirs of T. cruzi in northeastern Brazil and T. brasiliensis is the main triatomine species correlated with parasite transmission in domiciliary environments. There is a continuing need to control peridomiciliary populations of triatomines and to implement continuous surveillance strategies for reservoirs with the help from the community.
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- Hepatitis B Virus X Protein-Induced Serine Protease Inhibitor Kazal Type 1 Is Associated with the Progression of HBV-Related Diseases. [Journal Article]
- BRBiomed Res Int 2019; 2019:9321494
- CONCLUSIONS: HBV enhances expression of SPINK1 through X. SPINK1 levels are increased during progression of HBV-related diseases and might be utilized as a biomarker for the diagnosis of HBV-related diseases.