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Unbound Medicine.
(adalimumab)
10,577 results
  • Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis. [Case Reports]
    Front Immunol. 2022; 13:995304.Caruso C, Laterza L, … Gasbarrini A
  • We described a case of IPEX syndrome successfully controlled with dupilumab, an anti-IL4 receptor alpha subunit inhibitor. IPEX syndrome is a rare and generally fatal genetic disorder characterized by immune dysregulation, polyendocrinopathy and enteropathy, mostly diagnosed in early childhood. Nonetheless, cases reported in the last 20 years demonstrated that IPEX clinical spectrum encompasses m…
  • Juvenile idiopathic arthritis in an adult Filipino female: A case report. [Journal Article]
    Int J Rheum Dis. 2023 Jan 27 [Online ahead of print]Dorado CA, Vista ES
  • CONCLUSIONS: JIA is a complicated disease which begins early in life and affects patients even in adulthood. These patients may suffer from arthritis with permanent joint deformities and uveitis, among other disabilities that make daily tasks impossible, impacting patients both mentally and socially.
  • DRESS/DiHS syndrome induced by Propylthiouracil: a case report. [Case Reports]
    BMC Endocr Disord. 2023 Jan 23; 23(1):22.Shen Q, Wang Q, … Chen L
  • CONCLUSIONS: Propylthiouracil is a rare cause of the DRESS/DiHS syndrome, which typically consists of severe dermatitis and various degrees of internal organ involvement. We want to emphasize through this severe case that DRESS/DiHS syndrome should be promptly recognized to hasten recovery.
  • B-cell and complement signature in severe hidradenitis suppurativa that does not respond to adalimumab. [Journal Article]
    Br J Dermatol. 2023 Jan 23; 188(1):52-63.Hambly R, Gatault S, … Kirby B
  • CONCLUSIONS: This highlights the potential for targeting B-cell and complement pathways in HS treatment and the potential of stratifying patients at baseline to the most suitable treatment based on the skin transcriptome. CCL28 has not previously been identified in HS skin and has potential clinical relevance due to its antimicrobial function and homing of B and T cells at epithelial surfaces. Our results provide data to inform future translational and clinical studies on therapeutics in HS.
  • Update on the systemic management of non-infectious uveitis in children and adolescents. [Review]
    Surv Ophthalmol. 2023 Jan 19 [Online ahead of print]Leal I, Steeples LR, … Ashworth J
  • Non-infectious uveitis (NIU) in children and adolescents is a rare but treatable cause of visual impairment in children. Treatments for pediatric NIU and their side effects, alongside the risks of vision loss and need for long-term disease monitoring, pose significant challenges for young patients and their families. Treatment includes local and systemic approaches and this review will focus on s…
  • Analysis of drug-induced liver-related adverse event trend reporting between 1997 and 2019. [Journal Article]
    Hepatol Res. 2023 Jan 20 [Online ahead of print]Kamimura H, Setsu T, … Terai S
  • CONCLUSIONS: Although liver-related adverse events are largely caused by host immunity and other constitutional factors, differences in primary diseases, countries, and historical backgrounds lead to differences in the number of reports. Securing an appropriate database and a mechanism to collect real-time information on the frequency of adverse drug reactions is warranted. This article is protected by copyright. All rights reserved.
  • Dupilumab-Induced Lichen Planus: A Case with Oral and Cutaneous Eruptions. [Case Reports]
    Case Rep Dermatol. 2022 Sep-Dec; 14(3):356-361.Kern L, Kleinheinrich L, … Breier F
  • Lichen planus is a chronic, inflammatory, immune-mediated dermatosis affecting the patient's skin, scalp, mucous membranes, and nails. Drug-induced lichen planus is described after the administration of antimalarials, β-blockers, methyldopa, NSAIDs, penicillamines, and sodium aurothiomalate. The use of biologicals such as adalimumab, etanercept, and infliximab has also been linked with the appear…
  • Impact of stress on the immunogenic potential of adalimumab. [Journal Article]
    J Pharm Sci. 2023 Jan 12 [Online ahead of print]Heljo P, Ahmadi M, … Jiskoot W
  • Monoclonal antibodies against tumor necrosis factor-alpha (TNFα) are widely used for treatment of inflammatory diseases. However, despite the inhibitory effect this class of drugs has on the immune system, anti-drug antibodies are often formed with continuous use. Particles formed during stress conditions, which can be used to simulate storage and handling conditions of commercial antibodies, hav…
  • Drugs and Lactation Database (LactMed): Adalimumab [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Limited information indicates that maternal adalimumab injections produce low levels in breastmilk and do not adversely affect the nursing infant. Because adalimumab is a large protein molecule with a molecular weight of about 148,000 Da, it is likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. Most experts and professional gu…
  • Treatments for early-stage Dupuytren's disease: an evidence-based approach. [Review]
    J Hand Surg Eur Vol. 2023 Jan 13 [Online ahead of print]Nanchahal J, Chan JK
  • Current treatments for Dupuytren's disease are limited to late-stage disease when patients have developed flexion contractures and have impaired hand function. They all have limitations, including the risk of recurrence and complications. The use of treatments for early-stage disease, such as intralesional steroid injections or radiotherapy which lack a clear biological basis or evidence of effec…
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