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(adapter adaptor)
1,776 results
  • Retrograde Ret signaling controls sensory pioneer axon outgrowth. [Journal Article]
    Elife 2019; 8Tuttle A, Drerup CM, … Nechiporuk AV
  • The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret, displayed defects in peripheral sensory axon growth cone morphology and dynamics. Ret receptor was highly enriched in sensory pioneer neurons an…
  • CHID1 positively regulates RLR antiviral signaling by targeting the RIG-I/VISA signalosome. [Journal Article]
    J Med Virol 2019; 91(9):1668-1678Li SN, Ling T, … Xu LG
  • Retinoic acid-inducible gene-I (RIG-I) belongs to the RIGI-like receptors (RLRs), a class of primary pattern recognition receptors. It senses viral double-strand RNA in the cytoplasm and delivers the activated signal to its adaptor virus-induced signaling adapter (VISA), which then recruits the downstream TNF receptor-associated factors and kinases, triggering a downstream signal cascade that lea…
  • Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. [Journal Article]
    Science 2019; 363(6434)Sweere JM, Van Belleghem JD, … Bollyky PL
  • Bacteriophage are abundant at sites of bacterial infection, but their effects on mammalian hosts are unclear. We have identified pathogenic roles for filamentous Pf bacteriophage produced by Pseudomonas aeruginosa (Pa) in suppression of immunity against bacterial infection. Pf promote Pa wound infection in mice and are associated with chronic human Pa wound infections. Murine and human leukocytes…
  • Innate immune response in patients with acute Zika virus infection. [Journal Article]
    Med Microbiol Immunol 2019da Silva MHM, Moises RNC, … Fernandes JV
  • Innate immunity receptors (Toll-like receptors/TLRs and RIG-like receptors/RLRs) are important for the initial recognition of Zika virus (ZIKV), modulation of protective immune response, and IFN-α and IFN-β production. Immunological mechanisms involved in protection or pathology during ZIKV infection have not yet been determined. In this study, we evaluated the mRNA expression of innate immune re…
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