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272,061 results
  • Synthesis of Poly(ADP-ribose) Monomer Containing 2'-O-α-D-Ribofuranosyl Adenosine. [Journal Article]
    Curr Protoc Nucleic Acid Chem 2019; 78(1):e92Mikhailov SN, Drenichev MS, … Herdewijn P
  • In this article, the earlier reported procedure for the synthesis of 2'-O-β-D-ribofuranosyl nucleosides was extended to the synthesis of 2'-O-α-D-ribofuranosyl adenosine, a monomeric unit of poly(ADP-ribose). It consists in condensation of a small excess of 1-O-acetyl-2,3,5-tri-O-benzoyl-α,β-D-arabinofuranose activated with tin tetrachloride with 3',5'-O-tetra-isopropyldisiloxane-1,3-diyl-ribonuc…
  • Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells. [Journal Article]
    ACS Omega 2019; 4(11):14503-14510Alghamdi NJ, Balaraman L, … Boyd WC
  • The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N'-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extri…
  • Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol. [Journal Article]
    Sci Rep 2019; 9(1):13413Kobayashi M, Nishi K, … Kawai K
  • We examined whether [131I]6-β-iodomethyl-19-norcholesterol (NP-59), a cholesterol analog, can be used to measure function of hepatic drug transporters. Hepatic uptake of NP-59 with and without rifampicin was evaluated using HEK293 cells expressing solute carrier transporters. The stability of NP-59 was evaluated using mouse blood, bile, and liver, and human liver S9. Adenosine triphosphate-bindin…
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