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266,417 results
  • Epigenetic Hallmarks of Fetal Early Atherosclerotic Lesions in Humans. [Journal Article]
  • JCJAMA Cardiol 2018 Nov 07
  • de Nigris F, Cacciatore F, … Napoli C
  • CONCLUSIONS: The present study provides a stringent quantitative estimate of the magnitude of the association of maternal cholesterol levels during pregnancy with fetal aortic lesions and reveals the epigenetic response of fetal aortic SREBP2 to maternal cholesterol level. The role of maternal cholesterol level during pregnancy and epigenetic signature in offspring in cardiovascular primary prevention warrants further long-term causal relationship studies.
  • An Update On The Neurochemistry Of Essential Tremor. [Journal Article]
  • CMCurr Med Chem 2018 Nov 11
  • Jiménez-Jiménez FJ, Alonso-Navarro H, … Agúndez JAG
  • CONCLUSIONS: The most consistent data regarding neurochemistry of ET are related with the GABAergic and glutamatergic systems, with a lesser contribution of adenosine and dopaminergic and adrenergic systems, while there is not enough evidence of a definite role of other neurotransmitter systems in ET. The improvement of harmaline-induced tremor in rodent models achieved with T-type calcium channel antagonists, cannabinoid 1 receptor, sphingosine-1-phosphate receptor agonists, and gap-junction blockers, suggests a potential role of these structures in the pathogenesis of ET.
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