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258,732 results
  • Cell adhesion molecules in endometrial cancer - A systematic review. [Review]
    Adv Med Sci 2019; 64(2):423-429Lewczuk Ł, Pryczynicz A, Guzińska-Ustymowicz K
  • Adhesive molecules are responsible for the cell-cell interaction and the surrounding intercellular environment creating normal tissue architecture. The role of adhesion proteins in cancer refers to angiogenesis, loss of tissue continuity, and deprivation of intercellular contact with the extracellular matrix, promoting the spread of cancer through the formation of metastases. The integrity of the…
  • Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives. [Journal Article]
    J Mech Behav Biomed Mater 2019; 101:103405Shah AH, Djordjevic I, Steele TWJ
  • Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. N…
  • The Architecture of Talin1 Reveals an Autoinhibition Mechanism. [Journal Article]
    Cell 2019; 179(1):120-131.e13Dedden D, Schumacher S, … Mizuno N
  • Focal adhesions (FAs) are protein machineries essential for cell adhesion, migration, and differentiation. Talin is an integrin-activating and tension-sensing FA component directly connecting integrins in the plasma membrane with the actomyosin cytoskeleton. To understand how talin function is regulated, we determined a cryoelectron microscopy (cryo-EM) structure of full-length talin1 revealing a…
  • Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway. [Journal Article]
    FASEB J 2019; :fj201900799RRShan S, Fang B, … Li Q
  • Macrophages (Mφs) can be used as a part of cell-based cancer immunotherapy. However, they may be hampered by a failure to effectively and stably regulate their polarization state to enhance their tumoricidal effects. In this work, mechanical stretch (MS), as a biology-free modulatory method, was shown to enhance M1 polarization and tumoricidal effects. By using an in vitro Flexcell Tension system…
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