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420,592 results
  • Rapid microbiological tests for bloodstream infections due to multidrug resistant Gram-negative bacteria: therapeutic implications. [Review]
    Clin Microbiol Infect 2019Giacobbe DR, Giani T, … Rossolini GM
  • CONCLUSIONS: Novel molecular and phenotypic rapid tests for identification and AST show the potential for favorably influencing patients' outcomes and results of antimicrobial stewardship interventions, by reducing both the time to effective treatment and the misuse of antibiotics, although the interpretation about their impact on actual therapeutic decisions and patients' outcomes is still complex. Factors such as feasibility and personnel availability, as well as the detailed knowledge of the local microbiological epidemiology, need to be considered very carefully when implementing novel rapid tests in laboratory workflows and algorithms. Providing high-level, comparable evidence on the clinical impact of rapid identification and AST is becoming of paramount importance for MDR-GNB infections, since in the near future rapid identification of specific resistance mechanisms could be crucial for guiding rapid, effective, and targeted therapy against specific resistance mechanisms.
  • A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders. [Review]
    Life Sci 2019; :116925Xin Q, Yuan R, … Cong W
  • Inflammatory disorders result from abnormal immune response and their incidence has increased recently. Thus, there is an urgent need to discover new treatments for inflammatory disorders. In recent years, the natural products contained in Chinese herbs have attracted much attention worldwide owing to their anti-inflammatory effects. Paeoniflorin (PF) is a bioactive compound purified from the Chi…
  • Silver nanoparticles as a therapeutic agent in experimental cyclosporiasis. [Journal Article]
    Exp Parasitol 2019; :107772Gaafar MR, El-Zawawy LA, … Hassan AY
  • Cyclosporiasis is an emerging worldwide infection caused by an obligate intracellular protozoan parasite, Cyclospora cayetanensis. In immunocompetent patients, it is mainly manifested by self-limited diarrhea, which is persistent and may be fatal in immunocompromised patients. The standard treatment for cyclosporiasis is a combination of two antibiotics, trimethoprim and sulfamethoxazole. Gastroi…
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