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1,013 results
  • Development and prospective in-patient proof-of-concept of a surface photogrammetry + CT-based volumetric motion model for lung radiotherapy. [Journal Article]
    Med Phys 2019Ranjbar M, Sabouri P, … Sawant A
  • CONCLUSIONS: We described the development and a proof-of-concept validation for a volumetric motion model that uses surface photogrammetry to correlate the time-varying thoraco-abdominal surface to the time-varying internal thoraco-abdominal volume. These early results indicate that the proposed approach can result in a marked improvement over 4DCT. While limited by the duration of the fluoroscopic acquisitions as well as the resolution of the acquired images, the DRF-based proof-of-concept technique developed here is model-agnostic, and therefore, has the potential to be used as an in-patient validation tool for other volumetric motion models.
  • Topology-Aware Non-Rigid Point Cloud Registration. [Journal Article]
    IEEE Trans Pattern Anal Mach Intell 2019Zampogiannis K, Fermuller C, Aloimonos Y
  • In this paper, we introduce a non-rigid registration pipeline for unorganized point clouds that may be topologically different. Standard warp field estimation algorithms, even under robust, discontinuity-preserving regularization, produce erratic motion estimates on boundaries associated with 'close-to-open' topology changes. We overcome this limitation by exploiting backward motion: in the oppos…
  • Detection of Microsatellite Instability Biomarkers via Next-Generation Sequencing. [Journal Article]
    Methods Mol Biol 2020; 2055:119-132Bonneville R, Krook MA, … Roychowdhury S
  • A high level of microsatellite instability (MSI-H+) is an emerging predictive and prognostic biomarker for immunotherapy response in cancer. Recently, MSI-H+ has been detected in a variety of cancer types, in addition to the classical cancers associated with Lynch Syndrome. Clinical testing for MSI-H+ is currently performed primarily through traditional polymerase chain reaction (PCR) or immunohi…
  • SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase. [Journal Article]
    Proc Natl Acad Sci U S A 2019Zheng Q, Woehl JL, … Sharpless KB
  • Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and optimization of covalent inhibitors of human neutrophil elastase (hNE). Evaluation of our ever-growing collection of SuFExable compounds toward various biological assays unexpectedly revealed a selective and covalent hNE inhibitor: benzene-…
  • Olaparib in the treatment of ovarian cancer. [Journal Article]
    Future Oncol 2019Washington CR, Richardson DL, Moore KN
  • The poly ADP ribose polymerase olaparib is currently approved in front line BRCA-associated epithelial ovarian cancer (EOC), platinum-sensitive recurrence agnostic to BRCA status and for gBRCA as treatment in the fourth line and beyond. Women who are diagnosed with advanced stage EOC face a formidable challenge in overcoming their disease and achieving long-term, disease-free survival. The qualif…
  • Entrectinib OK'd for Cancers with NTRK Fusions, NSCLC. [Journal Article]
    Cancer Discov 2019
  • The FDA has approved entrectinib for patients with any solid tumor bearing NTRK fusions, making it the second TRK inhibitor to receive a tissue-agnostic approval; larotrectinib was the first. How the drugs compare to each other remains unknown. Entrectinib was also approved to treat metastatic non-small cell lung cancer with ROS1 rearrangements.
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