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174,966 results
  • The effect of the ghrelin-receptor agonist capromorelin on glucose metabolism in healthy cats. [Journal Article]
    Domest Anim Endocrinol. 2020 Apr 18; 74:106484.Pires J, Greathouse RL, … Gilor C
  • Somatostatin secretion from islet delta cells is important in maintaining low glycemic variability (GV) by providing negative feedback to beta cells and inhibiting insulin secretion. Capromorelin is a ghrelin-receptor agonist that activates the growth hormone secretagogue receptor on delta cells. We hypothesized that in cats, capromorelin administration will result in decreased GV at the expense …
  • Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model. [Journal Article]
    Stem Cell Reports. 2020 Jun 23 [Online ahead of print]Zhao M, Tazumi A, … Sakurai H
  • Duchenne muscular dystrophy (DMD) is a progressive and fatal muscle-wasting disease caused by DYSTROPHIN deficiency. Cell therapy using muscle stem cells (MuSCs) is a potential cure. Here, we report a differentiation method to generate fetal MuSCs from human induced pluripotent stem cells (iPSCs) by monitoring MYF5 expression. Gene expression profiling indicated that MYF5-positive cells in the la…
  • Dopamine and serotonin mediate the impact of stress on cleaner fish cooperative behavior. [Journal Article]
    Horm Behav. 2020 Jun 30 [Online ahead of print]de Abreu MS, Maximino C, … Soares MC
  • Stress is known to modulate behavioral responses and rapid decision-making processes, especially under challenging contexts which often occur in social and cooperative interactions. Here, we evaluated the effects of acute stress on cooperative behavior of the Indo-Pacific cleaner wrasse (Labroides dimidiatus) and the implications of pre-treatment with monoaminergic compounds: the selective seroto…
  • GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat. [Journal Article]
    Rev Neurosci. 2020 Jul 03 [Online ahead of print]Nikolaus S, Beu M, … Müller HW
  • In this review, a series of experiments is presented, in which γ-amino butyric acid (GABA)ergic and glutamatergic effects on dopamine function in the rat nigrostriatal and mesolimbic system was systematically assessed after pharmacological challenge with GABAA receptor (R) and and N-methyl d-aspartate (NMDA)R agonists and antagonists. In these studies, [123I]iodobenzamide binding to the D2/3R was…
  • Pharmacological treatment strategies for patients with monogenic obesity. [Review]
    J Pediatr Endocrinol Metab. 2020 Jul 03 [Online ahead of print]Kühnen P, Wiegand S, Biebermann H
  • The leptin melanocortin signaling pathway is playing a pivotal role for body weight regulation. Genetic defects within this cascade are leading to severe hyperphagia and early onset obesity. In most cases, due to persistent hyperphagia the affected patients are not able to stabilize body weight for a longer period of time with conservative treatment strategies based on lifestyle interventions. Th…
  • Appetite control: hormones or diet strategies? [Journal Article]
    Curr Opin Clin Nutr Metab Care. 2020 Jun 28 [Online ahead of print]Freire RH, Alvarez-Leite JI
  • CONCLUSIONS: Appetite control has been an important target for the treatment of obesity and associated disorders. New studies have demonstrated promising adoption of dietary approaches, hormone-based drugs, and bariatric surgery to control energy intake. Further research will establish a significant association, benefits, and safety of these new therapies.
  • Brexpiprazole in the treatment of schizophrenia and agitation in Alzheimer's disease. [Journal Article]
    Neurodegener Dis Manag. 2020 Jul 03 [Online ahead of print]Stummer L, Markovic M, Maroney M
  • Schizophrenia is a disabling psychiatric disorder marked by progressive loss of functionality in activities of daily living with each relapse. Antipsychotics, the mainstay of therapy for schizophrenia, treat hallucinations and delusions but may have intolerable side effects, including metabolic disturbances and extrapyramidal symptoms. Brexpiprazole, a second-generation antipsychotic with dopamin…
  • Added Benefit of Immature Oocyte Maturation for Fertility Preservation in Women with Malignancy. [Journal Article]
    Reprod Sci. 2020 Jul 02 [Online ahead of print]Cohen Y, Tannus S, … Buckett W
  • To assess the added value of maturing immature oocytes collected during fertility preservation treatments in women with malignancy. A retrospective case-control study analyzing the results of 327 cancer patients undergoing fertility preservation treatments. Oocyte maturation rates and cycle parameters were compared between 3 types of fertility preservation treatments: (1) stimulated IVF cycle (n …
  • Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet. [Journal Article]
    Oxid Med Cell Longev. 2020; 2020:5304768.Nohara K, Kim E, … Yoo SH
  • Circadian clocks regulate metabolic processes in a tissue-specific manner, which deteriorates during aging. Skeletal muscle is the largest metabolic organ in our body, and our previous studies highlight a key role of circadian regulation of skeletal muscle mitochondria in healthy aging. However, a possible circadian regulation of cardiolipin (CL), the signature lipid class in the mitochondrial in…
  • Activity of vitamin D receptor agonists against dengue virus. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10835.Jaratsittisin J, Xu B, … Smith DR
  • Infections with the mosquito-transmitted dengue virus (DENV) are a pressing public health problem in many parts of the world. The recently released commercial vaccine for DENV has encountered some problems, and there is still no effective drug to treat infections. Vitamin D has a well characterized role in calcium and phosphorus homeostasis, but additionally has a role in the immune response to b…
  • PPARα activation directly upregulates thrombomodulin in the diabetic retina. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10837.Shiono A, Sasaki H, … Takagi H
  • Two large clinical studies showed that fenofibrate, a commonly used peroxisome proliferator-activated receptor α (PPARα) agonist, has protective effects against diabetic retinopathy. However, the underlying mechanism has not been clarified. We performed genome-wide analyses of gene expression and PPARα binding sites in vascular endothelial cells treated with the selective PPARα modulator pemafibr…
  • Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain. [Journal Article]
    J Biol Chem. 2020 Jul 02 [Online ahead of print]Marinelli R, Torquato P, … Galli F
  • Garcinoic acid (GA or δ-T3-13'COOH), is a natural vitamin E metabolite that has preliminarily been identified as a modulator of nuclear receptors involved in β-amyloid (Aβ) metabolism and progression of Alzheimer's disease (AD). In this study, we investigated GA's effects on Aβ oligomer formation and deposition. Specifically, we compared them with those of other vitamin E analogs and the soy isof…
  • GLP-1 promotes osteogenic differentiation of human ADSCs via the Wnt/GSK-3β/β-catenin pathway. [Journal Article]
    Mol Cell Endocrinol. 2020 Jun 29 [Online ahead of print]Li Y, Fu H, … Lu H
  • Glucagon-like peptide-1 (GLP-1) analogues are promising anti-diabetic drugs which had been shown to have beneficial effects on bone metabolism in clinical practice, but the molecular mechanism remains unclear. In this study, we evaluated whether GLP-1 can affect the "intestine-fat-bone axis" via the Wnt/GSK-3β/β-catenin pathway. We established a diabetic mouse model and then treated mice with GLP…
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