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169,795 results
  • Dopamine agonist resistant prolactinomas: any alternative medical treatment? [Review]
    Pituitary 2019Souteiro P, Karavitaki N
  • Consensus guidelines recommend dopamine agonists (DAs) as the mainstay treatment for prolactinomas. In most patients, DAs achieve tumor shrinkage and normoprolactinemia at well tolerated doses. However, primary or, less often, secondary resistance to DAs may be also encountered representing challenging clinical scenarios. This is particularly true for aggressive prolactinomas in which surgery and…
  • Disturbances of purinergic system in affective disorders and schizophrenia. [Review]
    Psychiatr Pol 2019; 53(3):577-587Malewska-Kasprzak MK, Permoda-Osip A, Rybakowski J
  • Purinergic system plays a role in the regulation of many psychological processes, including mood and activity. It consists of P1 receptors, with adenosine as the agonist, and P2 receptors, activated by nucleotides (e.g., adenosine 5'-triphosphate - ATP). Propounded disturbances of uric acid in affective disorders were related to the introduction of lithium for the treatment of these disorders in …
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