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(akee ackee)
58 results
  • Hederagenin glycosides from the fruits of Blighia unijugata. [Journal Article]
    Phytochemistry 2019; 162:260-269Petit B, Mitaine-Offer AC, … Lacaille-Dubois MA
  • A phytochemical investigation of Blighia unijugata led to the isolation of eleven hederagenin glycosides. Among these compounds, six are previously undescribed, two are described in their native forms for the first time and three are known whereas firstly isolated from Blighia unijugata. The structure of the undescribed compounds was elucidated on the basis of 2D NMR and mass spectrometry analyse…
  • Blighia sapida K.D. Koenig: A review on its phytochemistry, pharmacological and nutritional properties. [Review]
    J Ethnopharmacol 2019; 235:446-459Sinmisola A, Oluwasesan BM, Chukwuemeka AP
  • CONCLUSIONS: This review highlights the traditional uses of parts of the Ackee plant: the bark, the leaves, capsules, roots and seeds. They are used in the management of diverse disease conditions such as diarrhoea, conjunctivitis, fever, internal hemorrhage, dysentery, cutaneous skin infections, and bacterial infections amongst others. Only nineteen compounds have been reportedly isolated from the parts of B. sapida; Alkaloids, quinines, polyphenols, and steroids, their glycosides, sesquiterpenes and triterpenes. Some of the plant extracts and its isolated compounds showed anticancer, antimicrobial, antidiarrheal, antioxidant and hypoglycemic activities both in vitro and in vivo. The seed/leaves have also been used as insect repellants and the leaves have been reported to have lethal effects on larvae of various mosquitoes' species. The oil contains a lot of nutrients and may be considered for edible consumption after safety has been confirmed. Hypoglycin A and the less malignant hypoglycin B are found in the unripe aril of Ackee and consumption results in hypoglycemia, vomiting, gluconeogenesis disruption which can result in coma and death. The untapped economic potential of its fruits is glaring in West Africa countries.Though B.sapida has been put to enormous traditional use, the pharmacological studies conducted are not sufficient, most studies are either in-vivo or in-vitro. More work is required (well-designed pharmacological tests, randomized clinical trials) to evaluate these medicinal claims. This review provides a basis for future research. The isolation of more compounds,detailed pharmacological investigations, exploration of food use and detoxification techniques are key areas to investigate.
  • StatPearls: Ackee Fruit Toxicity [BOOK]
    StatPearls Publishing: Treasure Island (FL) Surmaitis Ryan R Drexel University College of Medicine Hamilton Richard J. RJ Drexel University BOOK
  • Ingestion of the unripened Ackee fruit (Blighia sapida) may result in the metabolic syndrome known as "Jamaican vomiting sickness." Clinical manifestations may include profuse vomiting, altered mental status, and hypoglycemia. Severe cases have been reported to cause seizures, hypothermia, coma, and death. Medical treatment is primarily supportive care with intravenous fluids and dextrose.[1][2]
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