- Use of Social Psychology to Improve Adherence to National Bronchiolitis Guidelines. [Journal Article]
- PedPediatrics 2018 Dec 05
- CONCLUSIONS: Traditional quality improvement efforts coupled with social psychology techniques resulted in improved guideline adherence in outpatient bronchiolitis management. Additional study will help identify which techniques are most effective for increasing guideline adherence in cases of low-value care.
- Measuring The Bipolar Charge Distributions of Fine Particle Aerosol Clouds of Commercial PMDI Suspensions Using a Bipolar Next Generation Impactor (bp-NGI). [Journal Article]
- PRPharm Res 2018 Nov 26; 36(1):15
- CONCLUSIONS: The bp-NGI was used to quantify the bipolar Q/m ratios of aerosol particles collected from the ISMs of commercial MDI products. The positive charge recorded for each of the three MDIs may have been enhanced by the presence of charged ice crystals formed from the propellant during the aerosolisation process.
- [Drug Output and Aerosol Characteristics of Different Jet Nebulisers for Adults While Simulating the Nebulisation of Salbutamol]. [Journal Article]
- PPneumologie 2018; 72(12):820-831
- CONCLUSIONS: The results of the in vitro simulation studies can be utilised to select an appropriate nebuliser for the individual patient. In order to enhance therapeutic efficacy and patient compliance, a nebuliser with a high RDDR should be selected.
- Randomized Clinical Trial Comparing Breath-Enhanced to Conventional Nebulizers in the Treatment of Children with Acute Asthma. [Journal Article]
- JPedJ Pediatr 2018 Nov 02
- CONCLUSIONS: Albuterol delivered via conventional jet nebulizer resulted in significantly greater improvement in FEV1 than albuterol delivered by breath-enhanced nebulizer, without significant differences in clinical measures. Conventional jet nebulizers may deliver albuterol to children with acute asthma more effectively than breath-enhanced nebulizers.
- Cell-based assays and molecular dynamics analysis of a boron-containing agonist with different profiles of binding to human and guinea pig beta2 adrenoceptors. [Journal Article]
- EBEur Biophys J 2018 Nov 01
- The design of beta2 adrenoceptor (β2AR) agonists is attractive because of their wide-ranging applications in medicine, and the details of agonist interactions with β2AR are interesting because it is ...
The design of beta2 adrenoceptor (β2AR) agonists is attractive because of their wide-ranging applications in medicine, and the details of agonist interactions with β2AR are interesting because it is considered a prototype for G-protein coupled receptors. Preclinical studies for agonist development have involved biological assays with guinea pigs due to a similar physiology to humans. Boron-containing Albuterol derivatives (BCADs) designed as bronchodilators have improved potency and efficacy compared with their boron-free precursor on guinea pig β2ARs (gpβ2ARs), and two of the BCADs (BR-AEA and boronterol) conserve these features on cells expressing human β2ARs (hβ2ARs). The aim of this study was to test the BCAD Politerol on gpβ2ARs and hβ2ARs in vitro and in silico. Politerol displayed higher potency and efficacy on gpβ2AR than on hβ2AR in experimental assays, possible explanations are provided based on molecular modeling, and molecular dynamics simulations of about 0.25 µs were performed for the free and bound states adding up to 2 µs in total. There were slight differences, particularly in the role of the boron atom, in the interactions of Politerol with gpβ2ARs and hβ2ARs, affecting movements of transmembrane domains 5-7, known to be pivotal in receptor activation. These findings could be instrumental in the design of compounds selective for hβ2ARs.
- A Machine Learning Approach to Predicting Need for Hospitalization for Pediatric Asthma Exacerbation at the Time of Emergency Department Triage. [Journal Article]
- AEAcad Emerg Med 2018 Nov 01
- CONCLUSIONS: Three of the four machine learning models performed well with decision trees preforming the worst. The gradient boosting machines model demonstrated a slight advantage over other approaches at predicting need for hospital-level care at the time of triage in pediatric patients presenting with asthma exacerbation. The addition of weight, SES, and weather data improved the performance of this model.
- Myoclonus induced by salbutamol: A case report [Journal Article]
- BBiomedica 2018 09 01; 38(3):303-307
- Salbutamol is a β2 adrenergic agonist widely prescribed in patients with obstructive and restrictive lung diseases. The main side effects associated with its use are tachycardia and tremor. Myoclonus...
Salbutamol is a β2 adrenergic agonist widely prescribed in patients with obstructive and restrictive lung diseases. The main side effects associated with its use are tachycardia and tremor. Myoclonus is an involuntary, irregular, abrupt, brief and sudden muscular contraction, which can be generalized, focal or multifocal.We report the case of a 61-year-old patient presenting with myoclonus difficult to treat who showed improvement only after the definitive discontinuation of the β2 adrenergic agonist. We describe the clinical findings, the interventions, and the outcomes related to the onset of myoclonus secondary to the use of salbutamol, as well as the possible genesis and importance of this adverse effect. We used the CARE guidelines to delineate the clinical case. Although myoclonus secondary to the use of different drugs has been described in the literature, as far as we know this is the fourth report of salbutamol-induced myoclonus to date.
- Free to breathe hard in the Tour de France. [Letter]
- LctLancet 2018 09 29; 392(10153):1114-1115
- Paradoxical Bronchoconstriction with Short-Acting Beta Agonist. [Journal Article]
- AJAm J Case Rep 2018 Oct 09; 19:1204-1207
- BACKGROUND Asthma is a common disease in the U.S.
BACKGROUND Asthma is a common disease in the U.S.
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- Safety and effectiveness of albuterol solutions with and without benzalkonium chloride when administered by continuous nebulization. [Journal Article]
- AJAm J Health Syst Pharm 2018 Nov 15; 75(22):1791-1797
- CONCLUSIONS: A study of hospitalized patients receiving CNA detected no significant difference in the frequency of poor response to therapy between groups receiving benzalkonium chloride-free versus benzalkonium chloride-containing albuterol products.