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44 results
  • Drugs and Lactation Database (LactMed): Alclometasone [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Alclometasone has not been studied during breastfeeding. Since only extensive application of the most potent of these drugs cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. …
  • Comparing prescribing patterns for topical corticosteroids based on their FDA indication by age. [Journal Article]
    Pediatr Dermatol. 2021 Jan; 38(1):115-118.Freeze ME, Balogh EA, … Fleischer AB
  • CONCLUSIONS: Much like other medications for AD treatment, TCS are sometimes used off-label. The off-label use of topical corticosteroids to treat pediatric AD highlights a gap between clinical practice and regulating guidelines. Additional pediatric studies would offer a greater body of evidence to maintain or expand label indications for the use of TCS in younger patients.
  • Cutaneous Manifestations of EGFR-Inhibitors in African Americans and Treatment Considerations. [Case Reports]
    J Drugs Dermatol. 2020 Sep 01; 19(9):894-896.Geisler AN, Noor SJ
  • Epidermal growth factor (EGFR)-inhibitors have emerged as the primary therapy in advanced solid tumor malignancies because of improvement in survival with overall favorable side effect profile. However, 50–90% of patients treated with EGFR-inhibitors develop a follicular or acneiform rash, which can be symptomatic and source of psychosocial distress, negatively impacting quality of life. As…
  • Atopic dermatitis made easy: The Schachner Ladder. [Journal Article]
    Pediatr Dermatol. 2019 Nov; 36(6):1017-1018.Oberlin KE, Nanda S
  • The vast majority of atopic dermatitis follows a mild, chronic relapsing course. In this article, we highlight the art and practice of treating atopic dermatitis based upon a foundation of maintenance care and a ladder of therapy that can teach patients and their families how to best tailor their pharmaceutical options to optimize the management of their disease.
  • A 12-year-old boy with foot lesions. [Case Reports]
    Pediatr Ann. 2013 Jan; 42(1):11-2.Zimmerman B, Chamlin SL
  • CME EDUCATIONAL OBJECTIVES: 1.Identify the clinical presentation of granuloma annulare.2.Describe the differential diagnosis for granuloma annulare.3.Discuss the appropriate management for granuloma annulare. A 12-year-old healthy male presented to the dermatology clinic for evaluation of lesions on his feet. The lesions were bilateral and had been present for at least 6 months. Multiple topical…
  • Subacute cutaneous lupus erythematosus presenting in a child. [Case Reports]
    Australas J Dermatol. 2002 Feb; 43(1):62-4.Ciconte A, Mills AE, … Marks R
  • A 5-year-old girl presented in summer with an erythematous, scaly annular eruption in a malar distribution. She had no symptoms or signs of systemic lupus erythematosus. A diagnosis of subacute cutaneous lupus erythematosus was made on the basis of the clinical and histological features, positive anti-Ro antibody and a mildly elevated erythrocyte sedimentation rate. All other investigations, incl…
  • New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. [Review]
    Am J Clin Dermatol. 2002; 3(1):47-58.Brazzini B, Pimpinelli N
  • Currently, topical glucocorticosteroids are the most frequently used drugs in dermatologic practice. Over the years, research has focused on strategies to optimize potency and, in particular, the anti-inflammatory and immunosuppressive capacity of these drugs, while minimizing adverse effects. However, 'ideal' topical corticosteroids have not yet been synthesized. They should be able to permeate …
  • Linear scleroderma in children. [Case Reports]
    Int J Dermatol. 1996 May; 35(5):330-6.Eubanks LE, McBurney EI, … Reed R
  • CONCLUSIONS: Linear scleroderma is a clinical diagnosis. The pathogenesis remains unknown. A consistently effective therapy has not been found, although diphenylhydantoin and ticlopidine hydrochloride should be evaluated in clinical trials.
  • Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids. [Clinical Trial]
    Arch Dermatol. 1995 Jan; 131(1):31-7.Lepoittevin JP, Drieghe J, Dooms-Goossens A
  • CONCLUSIONS: The statistical analysis confirms that tixocortol pivalate and hydrocortisone contact allergies are definitely associated, while reactions to budesonide are strongly correlated with the reactions to both the acetonide group and the ester group. These clinical observations are fully supported by the conformational analysis of the molecules involved in this study. Tixocortol pivalate and budesonide should certainly be added to the standard series for the detection of patients sensitized to corticosteroids.
  • Comparative investigation of the antiproliferative efficacy of alclometasone. [Journal Article]
    Arzneimittelforschung. 1989 Apr; 39(4):490-2.Lubach D, Kietzmann M, Neumann Y
  • In this study, the antiproliferative activity of a 0.05% alclometasone ointment (Alc, Delonal) on the epidermis of the mouse tail was investigated. We have found that Alc thins the epidermis to approximately the same extent as hydrocortisone acetate (1%), but has an extremely slighter epidermal thinning effect than betamethasone (betametasone-17,21-dipropionate, 0.064%, Diprosis). The incorporati…
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